Journal
ADVANCED SCIENCE
Volume 10, Issue 5, Pages -Publisher
WILEY
DOI: 10.1002/advs.202202416
Keywords
active targeting delivery; atherosclerosis; cerasomes; diagnosis and treatment; hyaluronic acid
Ask authors/readers for more resources
This study aims to develop a new approach for active targeting of atherosclerotic plaques using nano-agents for imaging and treatment. The use of CD44-targeted HA-guided cerasomes results in significant plaque regression and improved magnetic resonance imaging. This safe and efficient nano-formulation has potential applications in the treatment of atherosclerosis.
Early noninvasive screening and regression therapy for vulnerable atherosclerotic plaques remain challenging. In this study, it is aimed to develop a new approach for the active targeting of atherosclerotic plaques with nano-agents to aid imaging and treatment. Biocompatible hyaluronic acid (HA)-guided cerasomes are generated to selectively target CD44-positive cells within the plaque in in vitro studies and in vivo testing in Apoe(-/-) mice. Rosuvastatin (RST) is encapsulated in the HA-guided cerasome nano-formulation to produce HA-CC-RST, which results in significant plaque regression as compared to treatment with the free drug. Moreover, gadodiamide-loaded HA-CC enhances magnetic resonance images of vulnerable plaques, thereby attaining the goal of improved simultaneous treatment and imaging. Transcriptomic analysis confirms plaque regression with HA-CC-RST treatment, which potentially benefits from the anti-inflammatory effect of RST. In summary, a safe and efficient nano-formulation for the targeted delivery of active agents to atherosclerotic plaques is developed and may be applicable to other diagnostic and therapeutic agents for atherosclerosis treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available