Journal
ADVANCED SCIENCE
Volume 10, Issue 1, Pages -Publisher
WILEY
DOI: 10.1002/advs.202205208
Keywords
acidic-responsive; glutathione depletion; metal-organic frameworks; NIR-II imaging; synergistic therapy
Ask authors/readers for more resources
This study reports a pH-responsive i-motif DNA-mediated method to regulate the programmable behaviors of erbium-based rare-earth nanoparticles (ErNPs) on copper doped metal-organic framework (CPM) nanohybrids, achieving selective tumor accumulation and imaging.
Dynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH-responsive i-motif DNA-mediated strategy to tailor the programmable behaviors of erbium-based rare-earth nanoparticles (ErNPs) decorated copper doped metal-organic framework (CPM) nanohybrids (ECPM) under physiological conditions is reported. Within the acidic tumor microenvironment, the i-motif DNA strands are able to form quadruplex structures, resulting in the assembly of nanohybrids and selective tumor accumulation, which further amplify the ErNPs downconversion emission (1550 nm) signal for imaging. Meanwhile, the ECPM matrix acts as a near-infrared (NIR) photon-activated reactive oxygen species (ROS) amplifier through the singlet oxygen generation of the matrix in combination with its ability of intracellular glutathione depletion upon irradiation. In short, this work displays a classical example of engineering of nanoparticles, which will manifest the importance of developing nanohybrids with structural programmability in biomedical applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available