Optimising inflammatory bowel disease surveillance and dysplasia management-Where do we stand?

Review Gastroenterology & Hepatology

Endoscopic resection of colon dysplasia in patients with inflammatory bowel disease: a systematic review and meta-analysis

Babu P. Mohan et al.

Summary: The risk of colorectal cancer after dysplasia resection in patients with inflammatory bowel disease appears to be low, supporting the current strategy of resection and surveillance.

GASTROINTESTINAL ENDOSCOPY (2021)

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Article Gastroenterology & Hepatology

Management of inflammatory bowel disease associated colonic dysplasia: factors predictive of patient choice and satisfaction

Misha Kabir et al.

Summary: When facing prognostic uncertainty and conflicting choices in managing dysplasia in IBD patients, personalized communication is necessary. The study found that a substantial proportion of dysplasia-experienced patients did not feel well informed about the associated cancer risk and management, indicating a need for enhancing patient involvement in treatment decisions.

COLORECTAL DISEASE (2021)

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Article Gastroenterology & Hepatology

Endoscopic submucosal dissection is safe and feasible, allowing for ongoing surveillance and organ preservation in patients with inflammatory bowel disease

Amy L. Lightner et al.

Summary: This study aimed to investigate the safety, feasibility, and oncological outcomes of endoscopic submucosal dissection (ESD) in patients with inflammatory bowel disease (IBD). The results showed that ESD was safe and effective for complete removal of neoplastic lesions in IBD patients, allowing for ongoing endoscopic surveillance and organ preservation.

COLORECTAL DISEASE (2021)

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Review Gastroenterology & Hepatology

AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in Inflammatory Bowel Diseases: Expert Review

Sanjay K. Murthy et al.

Summary: Improvements in disease management, endoscopic technology, and quality have significantly transformed the conceptualization and management of inflammatory bowel disease-related dysplasia over the past 20 years. A conceptual model and best practice advice have been proposed for the prevention, detection, and management of colorectal dysplasia in individuals with inflammatory bowel disease. This expert review, commissioned by the American Gastroenterological Association, aims to provide timely guidance on a topic of high clinical importance to its membership.

GASTROENTEROLOGY (2021)

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Review Oncology

Predicting Colorectal Cancer Occurrence in IBD

Mehmet Yalchin et al.

Summary: Patients with colonic inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC), and are enrolled into a surveillance programme aimed at detecting dysplasia or early cancer. Current surveillance programmes are guided by clinical, endoscopic or histological predictors of colitis-associated CRC (CA-CRC). There has been significant progress in understanding predictors of disease progression and improvements in endoscopic technique and management, leading to a decrease in the incidence of CA-CRC over the past 50 years. However, there is still room for improvement in our molecular understanding of CA-CRC progression and better risk stratification for patients with IBD.

CANCERS (2021)

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Article Gastroenterology & Hepatology

Root-cause analyses of missed opportunities for the diagnosis of colorectal cancer in patients with inflammatory bowel disease

Claire Gordon et al.

Summary: The study found that patients with IBD have an increased risk of developing CRC compared to the general population, and the incidence of IBD-associated CRC has remained stable over the past 20 years. However, two-thirds of patients eligible for colonoscopic surveillance missed opportunities to diagnose CRC, indicating that surveillance programs lack comprehensive and fully integrated recall systems.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

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Article Gastroenterology & Hepatology