Prediction of infected pancreatic necrosis in acute necrotizing pancreatitis by the modified pancreatitis activity scoring system

Article Gastroenterology & Hepatology

The Modified Pancreatitis Activity Scoring System Shows Distinct Trajectories in Acute Pancreatitis: An International Study

Pedram Paragomi et al.

Summary: This study aims to evaluate the performance of the Pancreatitis Activity Scoring System (PASS) in a global patient cohort and investigate the predictive accuracy and distinct trajectories of a modified PASS. The results suggest that the modified PASS performs well in predicting disease severity and exhibits distinct trajectories between severity subgroups.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Critical Care Medicine

Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial

Lu Ke et al.

Summary: This study aimed to evaluate whether early immune-enhancing Thymosin alpha 1 (T alpha 1) treatment reduces the incidence of infected pancreatic necrosis in patients with predicted severe acute necrotising pancreatitis, but the results showed that this treatment did not reduce the incidence of IPN during the index admission.

INTENSIVE CARE MEDICINE (2022)

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Article Gastroenterology & Hepatology

Dynamic changes in the pancreatitis activity scoring system during hospital course in a multicenter, prospective cohort

Pedram Paragomi et al.

Summary: The study validated the Pancreatitis Activity Scoring System (PASS) in a cohort of acute pancreatitis patients and found significant differences in PASS trajectories among different severity levels and lengths of hospital stay groups.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

The Pancreatitis Activity Scoring System Predicts Clinical Outcomes in Patients With Infected Pancreatic Necrosis

Nikhil R. Thiruvengadam et al.

Summary: The PASS score was associated with postintervention clinical outcomes and early readmission in patients with infected pancreatic necrosis, indicating it is a valid measure of disease activity in this population. Further prospective validation of PASS in IPN is warranted.

PANCREAS (2021)

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Meeting Abstract Gastroenterology & Hepatology

ORGAN FAILURE AND INFECTED PANCREATIC NECROSIS AS DETERMINANTS OF MORTALITY IN PATIENTS WITH ACUTE PANCREATITIS: AN UPDATED SYSTEMATIC REVIEW AND META-ANALYSIS

Wenmo Hu et al.

GUT (2021)

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Article Gastroenterology & Hepatology

Trajectories of Lymphocyte Counts in the Early Phase of Acute Pancreatitis Are Associated With Infected Pancreatic Necrosis

Jing Zhou et al.

Summary: This study found that patients with a persistently low ALC trajectory during the early phase of AP are more likely to develop IPN. Therefore, monitoring the changes in ALC levels may help identify AP patients at risk of IPN.

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

The Pancreatitis Activity Scoring System Predicts Clinical Outcomes in Patients With Infected Pancreatic Necrosis

Nikhil R. Thiruvengadam et al.

Summary: The study evaluated the role of Pancreatitis Activity Scoring System (PASS) in infected pancreatic necrosis (IPN) and found that PASS score was associated with clinical outcomes and early readmission in IPN patients, confirming its validity as a measure of disease activity. Further prospective validation of PASS in IPN is recommended.

PANCREAS (2021)

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Editorial Material Gastroenterology & Hepatology