Systematic review and meta-analysis of prevalence, trajectories, and clinical outcomes for frailty in COPD

This systematic review synthesised measurement and prevalence of frailty in COPD and associations between frailty and adverse health outcomes. We searched Medline, Embase and Web of Science (1 January 2001-8 September 2021) for observational studies in adults with COPD assessing frailty prevalence, trajectories, or association with health-related outcomes. We performed narrative synthesis and random-effects meta-analyses. We found 53 eligible studies using 11 different frailty measures. Most common were frailty phenotype (n = 32), frailty index (n = 5) and Kihon checklist (n = 4). Prevalence estimates varied by frailty definitions, setting, and age (2.6-80.9%). Frailty was associated with mortality (5/7 studies), COPD exacerbation (7/11), hospitalisation (3/4), airflow obstruction (11/14), dyspnoea (15/16), COPD severity (10/12), poorer quality of life (3/4) and disability (1/1). In conclusion, frailty is a common among people with COPD and associated with increased risk of adverse outcomes. Proactive identification of frailty may aid risk stratification and identify candidates for targeted intervention.

Automated summary

This systematic review examined the measurement, prevalence, and associations of frailty in individuals with COPD. A total of 53 eligible studies were included, using 11 different frailty measures. The prevalence of frailty varied depending on the definition and population. Frailty was found to be associated with adverse health outcomes, including mortality, exacerbations, hospitalization, airflow obstruction, dyspnea, COPD severity, lower quality of life, and disability. The proactive identification of frailty may help in risk stratification and targeted interventions for individuals with COPD.