Journal
NANOMATERIALS
Volume 12, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/nano12223993
Keywords
fishbone; demineralization; nano hydroxyapatite; remineralization
Categories
Funding
- Basic Science Research Program through the National Research Foundation (NRF) of Korea [2018R1A6A1A03024231, 2021R1A2C1003566]
- Yenepoya Research Centre, Yenepoya (Deemed to be University)
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This study successfully isolated hydroxyapatite from fish bone, which exhibits excellent biocompatibility and bioactivity, and enhances cell proliferation. The researchers evaluated the remineralization potential of the isolated nano HA and found its potential in treating early caries.
Dental caries is a common problem in adolescents, leading to permanent loss of teeth or cavitation. Caries is a continuous process wherein demineralization and remineralization occur regularly. Hydroxyapatite (HA) is one of the most biocompatible and bioactive materials, as it closely resembles the mineral composition of teeth. The present study deals with isolating hydroxyapatite from fish bone (Epinephelus chlorostigma) by alkaline hydrolysis and thermal calcination. The isolated nano HA was characterized using FT-IR, XRD, TGA, FE-SEM-EDX, and HR-TEM analysis. The nano HA isolated by alkaline hydrolysis is nontoxic, and the cells are viable. The isolated HA enhances the proliferation of L929 cells. The remineralization potential of the extracted nano HA was evaluated in healthy premolars by DIAGNOdent/laser fluorescence quantification, surface microhardness test, and SEM-EDX analysis. Surface morphological observations in SEM and EDX analyses show that thermally calcined HA and alkali-treated HA can induce mineralization and deposit minerals. Therefore, HA obtained from Epinephelus chlorostigma could be a potential biomaterial for treating early caries.
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