A New Electrochemical Sensor for the Detection of Ketoconazole Using Carbon Paste Electrode Modified with Sheaf-like Ce-BTC MOF Nanostructure and Ionic Liquid

An ultrasensitive and selective voltammetric sensor with an ultratrace-level detection limit is introduced for ketoconazole (KTC) determination in real samples using a modified carbon paste electrode with a sheaf-like Ce-BTC MOF nanostructure and ionic liquid. The as-synthesized nanostructure was characterized by several techniques, including energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and field emission scanning electron microscopy (FE-SEM). The electrocatalytic performance of the developed electrode was observed by cyclic voltammetry (CV), differential pulse voltammetry (DPV), linear sweep voltammetry (LSV), and chronoamperometry. The limit of detection (LOD) of the developed sensor for KTC is 0.04 mu M, and the response was found to be in the dynamic concentration range of 0.1-110.0 mu M in a phosphate buffer solution. The proposed electrode exhibits acceptable electrocatalytic activity for KTC oxidation with a high sensitivity of 0.1342 mu A center dot mu M-1. The ability of the fabricated sensor to monitor KTC in real aqueous samples is demonstrated using standard addition data.

Automated summary

This article introduces an ultrasensitive and selective voltammetric sensor for the determination of ketoconazole (KTC) in real samples. It utilizes a modified carbon paste electrode with a sheaf-like Ce-BTC MOF nanostructure and ionic liquid. The electrode exhibits excellent electrocatalytic activity for KTC oxidation, with a detection limit of 0.04 μM and a sensitivity of 0.1342 μA·μM-1. It can effectively monitor KTC in aqueous samples.