4.7 Article

Activity of Sodium Trimetaphosphate Nanoparticles on Cariogenic-Related Biofilms In Vitro

Journal

NANOMATERIALS
Volume 13, Issue 1, Pages -

Publisher

MDPI
DOI: 10.3390/nano13010170

Keywords

phosphates; fluorides; nanotechnology; Streptococcus mutans; Candida albicans; dental caries; biofilms; extracellular matrix

Ask authors/readers for more resources

This study evaluated the effects of sodium trimetaphosphate nanoparticles (TMPn) on dual-species biofilms of Streptococcus mutans and Candida albicans. The results showed that 3% TMPn/F significantly reduced carbohydrate content and increased pH in the biofilms after sucrose exposure. In addition, it increased phosphorus (P) and fluoride (F) levels in the biofilm fluid before sucrose exposure.
In light of the promising effect of sodium trimetaphosphate nanoparticles (TMPn) on dental enamel, in addition to the scarce evidence of the effects of these nanoparticles on biofilms, this study evaluated the activity of TMPn with/without fluoride (F) on the pH, inorganic composition and extracellular matrix (ECM) components of dual-species biofilms of Streptococcus mutans and Candida albicans. The biofilms were cultivated in artificial saliva in microtiter plates and treated with solutions containing 1% or 3% conventional/microparticulate TMP (TMPm) or TMPn, with or without F. After the last treatment, the protein and carbohydrate content of the ECM was analyzed, and the pH and F, calcium (Ca), phosphorus (P), and TMP concentrations of the biofilms were determined. In another set of experiments, after the last treatment, the biofilms were exposed to a 20% sucrose solution, and their matrix composition, pH, and inorganic component contents were evaluated. 3% TMPn/F significantly reduced ECM carbohydrate and increased biofilm pH (after sucrose exposure) than other treatments. Also, it significantly increased P and F levels before sucrose exposure in comparison to 3% TMPm/F. In conclusion, 3% TMPn/F affected the biofilm ECM and pH, besides influencing inorganic biofilm composition by increasing P and F levels in the biofilm fluid.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available