Journal
ADVANCED MATERIALS
Volume 28, Issue 6, Pages 1312-1318Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502581
Keywords
hemoglobin; nanoarchitectonics; layer-by-layer assembly; oxygen carriers
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Funding
- National Nature Science Foundation of China [21433010, 21320102004, 21303221, 21321063]
- National Basic Research Program of China (973 program) [2013CB932800]
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Safe and effective artificial oxygen carriers are the subject of great interest due to the problems of traditional blood transfusion and enormous demand in clinical use. In view of its unique oxygen-transport ability and normal metabolic pathways, hemoglobin is regarded as an ideal oxygen-carrying unit. With advances in nano-biotechnology, hemoglobin assemblies as artificial oxygen carriers achieve great development. Here, recent progress on hemoglobin-based oxygen carriers is highlighted in view of two aspects: acellular hemoglobin-based oxygen carriers and cellular hemoglobin-based oxygen carriers. These novel oxygen carriers exhibit advantages over traditional carriers and will greatly promote research on reliable and feasible oxygen carriers.
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