4.3 Article

Brain-derived neurotrophic factor, neurofilament light and glial fibrillary acidic protein do not change in response to aerobic training in people with MS-related fatigue - a secondary analysis of a randomized controlled trial

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Aerobic Exercise Alters Brain Function and Structure in Parkinson's Disease: A Randomized Controlled Trial

Martin E. Johansson et al.

Summary: This study conducted a clinical trial and found that aerobic exercise can improve motor symptoms and cognitive control in patients with Parkinson's disease. It also showed positive effects on the structural and functional changes in the brain, suggesting that aerobic exercise can stabilize disease progression in the corticostriatal sensorimotor network.

ANNALS OF NEUROLOGY (2022)

Review Clinical Neurology

Fitness, physical activity, and exercise in multiple sclerosis: a systematic review on current evidence for interactions with disease activity and progression

Sebastian Proschinger et al.

Summary: Exercise may improve certain clinical measures in patients with multiple sclerosis, but it is difficult to conclude a supportive disease-modifying effect. Existing studies have limitations such as low evidence quality and short intervention duration, highlighting the need for more high-quality research to evaluate the role of exercise in multiple sclerosis.

JOURNAL OF NEUROLOGY (2022)

Article Clinical Neurology

Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study

Pascal Benkert et al.

Summary: sNfL is a biomarker of neuronal damage used in monitoring disease activity in multiple sclerosis patients. This study established a reference database to correct for age and BMI, showing sNfL's potential in identifying individuals at risk for future disease activity. The results suggest that sNfL Z scores could predict acute and chronic disease activity in multiple sclerosis patients, with higher Z scores indicating increased risk.

LANCET NEUROLOGY (2022)

Review Multidisciplinary Sciences

Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials

Parnian Shobeiri et al.

Summary: This study conducted a meta-analysis to investigate the influence of exercise on brain-derived neurotrophic factor (BDNF) levels in patients with multiple sclerosis (MS). The results showed that exercise increased peripheral levels of BDNF in MS patients. The study also found that the quality of the included studies might contribute to heterogeneity, while age and disease severity did not have a significant effect on BDNF levels.

PLOS ONE (2022)

Review Neurosciences

Reactive astrocyte nomenclature, definitions, and future directions

Carole Escartin et al.

Summary: The article highlights the challenges and uncertainties surrounding reactive astrocytes, advocating for comprehensive research that includes assessment of multiple molecular and functional parameters, preferably in vivo, along with multivariate statistics and determination of impact on pathological hallmarks in relevant models.

NATURE NEUROSCIENCE (2021)

Article Clinical Neurology

The effect of aerobic exercise on Neurofilament light chain and glial Fibrillary acidic protein level in patients with relapsing remitting type multiple sclerosis

Zubeyde Ercan et al.

Summary: This study demonstrated that serum GFAP and NFL levels decreased in RRMS patients after aerobic exercise, which may be promising in understanding the regulation of disease activity in MS patients by investigating the effects of aerobic exercise on individuals with RRMS and elucidating the underlying measurable biomarkers.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Review Neurosciences

Effects of Exercise Training on Neurotrophic Factors and Subsequent Neuroprotection in Persons with Multiple Sclerosis-A Systematic Review and Meta-Analysis

Mette D. Diechmann et al.

Summary: This study systematically reviewed the effects of acute and chronic exercise on neurotrophic factors in individuals with multiple sclerosis, finding that exercise can improve chronic levels of neurotrophic factors, especially brain-derived neurotrophic factor (BDNF).

BRAIN SCIENCES (2021)

Article Geriatrics & Gerontology

Associations Between Physical Activity, Blood-Based Biomarkers of Neurodegeneration, and Cognition in Healthy Older Adults: The MAPT Study

Jeremy Raffin et al.

Summary: This study found that physical activity is associated with blood NFL concentrations, but not with A beta(42/40). Furthermore, it suggests that physical activity may attenuate the negative association between amyloid load and cognition, while having high NFL levels mitigates the favorable relationship between physical activity and cognition. Additional research on nondemented older adults is needed for further validation of these findings.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

Article Clinical Neurology

Exercise Diminishes Plasma Neurofilament Light Chain and Reroutes the Kynurenine Pathway in Multiple Sclerosis

Niklas Joisten et al.

Summary: This study found that high-intensity interval training has better training effects on patients with multiple sclerosis, affecting plasma neurofilament light chain and tryptophan degradation metabolites more significantly. Additionally, acute exercise may introduce confounding factors for measurement reliability.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

Review Behavioral Sciences

Effects of physical exercise on plasma brain-derived neurotrophic factor in neurodegenerative disorders: A systematic review and meta-analysis of randomized controlled trials

David Ruiz-Gonzalez et al.

Summary: Exercise interventions significantly increase plasma BDNF levels in individuals with neurodegenerative disorders, with particularly notable effects in multiple sclerosis and Parkinson's disease; irrespective of exercise type, weekly exercise volume, and intervention length, BDNF levels showed significant increases.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

Article Rehabilitation

IMPACT OF AEROBIC EXERCISE ON CLINICAL AND MAGNETIC RESONANCE IMAGING BIOMARKERS IN PERSONS WITH MULTIPLE SCLEROSIS: AN EXPLORATORY RANDOMIZED CONTROLLED TRIAL

Lina Savsek et al.

Summary: The study found that aerobic exercise had a positive effect on the volume of some brain substructures in patients with multiple sclerosis, potentially indicating a slowing of the neurodegenerative process. However, the impact on other brain substructures was heterogeneous, with overall minor effects. Further research is needed to determine the exact implications of these findings.

JOURNAL OF REHABILITATION MEDICINE (2021)

Review Neurosciences

Exercise in multiple sclerosis and its models: Focus on the central nervous system outcomes

Ling Yi Guo et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2020)

Article Clinical Neurology

Serum glial fibrillary acidic protein correlates with multiple sclerosis disease severity

Heidi Hogel et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

Article Clinical Neurology

Exercise improves neurotrophins in multiple sclerosis independent of disability status

Ebrahim Banitalebi et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

Review Clinical Neurology

Serum neurofilament light as a biomarker in progressive multiple sclerosis

Raju Kapoor et al.

NEUROLOGY (2020)

Article Multidisciplinary Sciences

Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity

Xavier Ayrignac et al.

SCIENTIFIC REPORTS (2020)

Review Biochemistry & Molecular Biology

Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration

B. Mahalakshmi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Correction Multidisciplinary Sciences

Serum GFAP as a biomarker for disease severity in multiple sclerosis (vol 8, 14798, 2018)

A. Abdelhak et al.

SCIENTIFIC REPORTS (2019)

Review Immunology

Molecular biomarkers in multiple sclerosis

Tjalf Ziemssen et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Article Clinical Neurology

Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

Tue Kjolhede et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Article Clinical Neurology

Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

Tue Kjolhede et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Review Medicine, General & Internal

Multiple sclerosis

Alan J. Thompson et al.

LANCET (2018)

Review Medicine, General & Internal

Aerobic Exercise: Evidence for a Direct Brain Effect to Slow Parkinson Disease Progression

J. Eric Ahlskog

MAYO CLINIC PROCEEDINGS (2018)

Review Clinical Neurology

Effects of exercise training on cytokines and adipokines in multiple Sclerosis: A systematic review

Raoof Negaresh et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2018)

Review Clinical Neurology

Neurofilaments as biomarkers in neurological disorders

Michael Khalil et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Sport Sciences

The effect of 12-weeks resistance and endurance training on the serum levels NGF, BDNF, and VDBP in women with multiple sclerosis

Mitra Khademosharie et al.

INTERNATIONAL JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (2018)

Article Medicine, Research & Experimental

Different ways to estimate treatment effects in randomised controlled trials

J. Twisk et al.

CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS (2018)

Review Immunology

Peripheral blood biomarkers in multiple sclerosis

Antonella D'Ambrosio et al.

AUTOIMMUNITY REVIEWS (2015)

Review Clinical Neurology

Neurofilaments as biomarkers in multiple sclerosis

Charlotte E. Teunissen et al.

MULTIPLE SCLEROSIS JOURNAL (2012)

Review Clinical Neurology

The benefits of exercise training in multiple sclerosis

Robert W. Motl et al.

NATURE REVIEWS NEUROLOGY (2012)

Article Clinical Neurology

Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis

M. Axelsson et al.

JOURNAL OF NEUROLOGY (2011)

Review Clinical Neurology

Brain-derived neurotrophic factor in neurodegenerative diseases

Chiara Zuccato et al.

NATURE REVIEWS NEUROLOGY (2009)

Review Physiology

Role and Therapeutic Potential of VEGF in the Nervous System

Carmen Ruiz De Almodovar et al.

PHYSIOLOGICAL REVIEWS (2009)

Review Neurosciences

Exercise builds brain health: key roles of growth factor cascades and inflammation

Carl W. Cotman et al.

TRENDS IN NEUROSCIENCES (2007)