4.6 Review

Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease

Related references

Note: Only part of the references are listed.
Review Gastroenterology & Hepatology

Diet and gut microbiome in fatty liver and its associated liver cancer

Yasi Pan et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease worldwide, with the gut microbiome and dietary components playing important roles in its development and its related hepatocellular carcinoma (HCC). Components in the diet such as cholesterol, fiber, fat, and sugar can alter the gut microbiome composition, consequently affecting the progression of NAFLD and related conditions.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Nutrition & Dietetics

Plasma Alkylresorcinol Metabolite, a Biomarker for Whole-Grain Intake, Is Inversely Associated with Risk of Nonalcoholic Fatty Liver Disease in a Case-Control Study of Chinese Adults

Taoping Sun et al.

Summary: The study found that increased plasma DHPPA concentration is associated with a lower risk of NAFLD in Chinese adults, independently of well-known risk factors.

JOURNAL OF NUTRITION (2022)

Review Medicine, General & Internal

An Update in Epigenetics in Metabolic-Associated Fatty Liver Disease

J. Samael Rodriguez-Sanabria et al.

Summary: Metabolic-associated fatty liver disease (MAFLD) is characterized by excessive fat accumulation in hepatocytes and is closely related to overweight, obesity, type 2 diabetes, and metabolic dysregulation. Epigenetic patterns, including DNA methylation, histone modifications, and miRNA expression, play a crucial role in the pathophysiology and progression of MAFLD. Understanding these epigenetic mechanisms could provide new therapeutic targets and non-invasive biomarkers for MAFLD.

FRONTIERS IN MEDICINE (2022)

Article Nutrition & Dietetics

Litchi-Derived Polyphenol Alleviates Liver Steatosis and Gut Dysbiosis in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blinded, Placebo-Controlled Study

Thananya Jinato et al.

Summary: This study provides evidence that oligonol improves liver steatosis by modulating gut bacterial composition, suggesting its potential therapeutic role in treating non-alcoholic fatty liver disease (NAFLD).

NUTRIENTS (2022)

Article Gastroenterology & Hepatology

Impact of the Association Between PNPLA3 Genetic Variation and Dietary Intake on the Risk of Significant Fibrosis in Patients With NAFLD

Eduardo Vilar-Gomez et al.

Summary: This study suggests that the PNPLA3 rs738409 G-allele may modulate the effect of specific dietary nutrients on the risk of fibrosis in patients with NAFLD. Associations between certain dietary factors and significant fibrosis were stronger among rs738409 G-allele carriers.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

Article Medicine, Research & Experimental

Altered vitamin A metabolism in human liver slices corresponds to fibrogenesis

Lindsay C. Czuba et al.

Summary: Research shows that acute liver injury leads to complex changes in vitamin A metabolic flux in the liver, including an increase in tissue concentrations of atRA, decreased retinyl ester and atRA formation rates, and time-dependent changes in the expression of metabolizing enzymes. These early changes precede HSC activation and upregulation of profibrogenic gene expression, indicating that HSC and Kupffer cells are key cells involved in alterations to vitamin A metabolic flux and signaling after liver injury.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2021)

Article Nutrition & Dietetics

Differential response to a 6-month energy-restricted treatment depending on SH2B1 rs7359397 variant in NAFLD subjects: Fatty Liver in Obesity (FLiO) Study

Nuria Perez-Diaz-del-Campo et al.

Summary: The study found that the SH2B1 rs7359397 genetic variant has a certain influence on body composition, metabolic status, and liver health in overweight/obese NAFLD patients, especially under energy-restricted treatment.

EUROPEAN JOURNAL OF NUTRITION (2021)

Article Gastroenterology & Hepatology

Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial

Anat Yaskolka Meir et al.

Summary: The study found that a green-Mediterranean diet (MED) is more effective in reducing non-alcoholic fatty liver disease (NAFLD), with a greater decrease in intrahepatic fat (IHF) content, by further restricting red/processed meat and increasing intake of green plants and polyphenols. This healthy dietary strategy shows promising results in reducing IHF and decreasing NAFLD prevalence.
Article Endocrinology & Metabolism

Untargeted metabolomics as a diagnostic tool in NAFLD: discrimination of steatosis, steatohepatitis and cirrhosis

Mario Masarone et al.

Summary: The study utilized metabolomics analysis to differentiate metabolic profiles of different stages in NAFLD patients, revealing key metabolites that could potentially serve as biomarkers for disease progression. Additionally, the use of an ensemble machine learning model demonstrated high accuracy in predicting clinical stages of NAFLD.

METABOLOMICS (2021)

Review Environmental Sciences

Nutritional Approach Targeting Gut Microbiota in NAFLD-To Date

Malgorzata Moszak et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a significant global issue affecting approximately 25% of the adult population, with recent studies highlighting the crucial role of gut microbiota dysbiosis in its pathogenesis. Nutritional therapy, including probiotics, prebiotics, and symbiotics, may be a promising tool in treating NAFLD by reversing dysbiosis.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Biochemistry & Molecular Biology

Effect of exercise and diet intervention in NAFLD and NASH via GAB2 methylation

Na Wu et al.

Summary: The study found that exercise and diet intervention can affect DNA methylation of GAB2 in NAFLD and NASH patients, protecting them from disease progression. It also demonstrated that DNA methylation variations in blood can reflect epigenetic signatures in target tissues such as liver and adipose tissue.

CELL AND BIOSCIENCE (2021)

Review Endocrinology & Metabolism

Human Genetics to Identify Therapeutic Targets for NAFLD: Challenges and Opportunities

Xiaomi Du et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a heritable disease with several genetic loci associated with different stages identified through genetic association studies. Recent research has identified novel genes related to NAFLD, some of which show therapeutic promise. Challenges in diagnosis due to heterogeneity in NAFLD phenotypes and diagnostic methods call for accelerated genetic mapping studies to identify therapeutic targets.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Biochemistry & Molecular Biology

Contribution of Metabolomics to the Understanding of NAFLD and NASH Syndromes: A Systematic Review

Cristina Piras et al.

Summary: Metabolites of amino acids, fatty acids, and vitamins were found to be significantly different in patients with NAFLD and NASH compared to healthy controls. These findings suggest that low weight metabolites are important indicators for NAFLD/NASH and there is a strong overlap between these conditions and the metabolic syndrome, offering new perspectives for diagnosis and interventions.

METABOLITES (2021)

Review Medicine, General & Internal

Liver Fibrosis and MAFLD: From Molecular Aspects to Novel Pharmacological Strategies

Weiyi Qu et al.

Summary: MAFLD/NAFLD, caused by nutrition overload leading to liver damage, lacks effective treatments for fibrosis reversal. Research on antifibrotic treatments focuses on discovering new targets and drugs, but challenges remain in achieving significant breakthroughs.

FRONTIERS IN MEDICINE (2021)

Article Gastroenterology & Hepatology

Effects of lifestyle interventions on epigenetic signatures of liver fat: Central randomized controlled trial

Anat Yaskolka Meir et al.

Summary: In the CENTRAL trial, diverse liver fat dynamics were observed in response to different dietary interventions. Epigenetic mechanisms and genetic factors contribute to the variation in intrahepatic fat levels and development of NAFLD. However, long-term lifestyle interventions may lead to epigenetic remodeling and changes in DNA methylation patterns associated with IHF.

LIVER INTERNATIONAL (2021)

Article Nutrition & Dietetics

PNPLA3 Genotype, Arachidonic Acid Intake, and Unsaturated Fat Intake Influences Liver Fibrosis in Hispanic Youth with Obesity

Roshonda B. Jones et al.

Summary: This study found that arachidonic acid intake is associated with liver fibrosis, while reducing intake of polyunsaturated fatty acids might be important for preventing non-alcoholic fatty liver disease progression, especially among individuals with PNPLA3 risk alleles. Sex, genotype, and liver fat can affect the association between dietary types and liver fibrosis.

NUTRIENTS (2021)

Review Endocrinology & Metabolism

Metabolic-associated fatty liver disease and lipoprotein metabolism

Joerg Heeren et al.

Summary: MAFLD is characterized by pathological accumulation of triglycerides in hepatocytes and is closely related to disturbances in systemic energy metabolism. Liver plays a central role in lipid metabolism, with excessive hepatic triglyceride synthesis being a key factor in the development of MAFLD. Interventions targeting lipid storage and energy combustion in adipose tissues may help ameliorate MAFLD.

MOLECULAR METABOLISM (2021)

Article Chemistry, Medicinal

Black Mulberry Extract Elicits Hepatoprotective Effects in Nonalcoholic Fatty Liver Disease Models by Inhibition of Histone Acetylation

Min-Yu Chung et al.

Summary: The study demonstrates that black mulberry fruit extract (BME) exhibits hypolipidemic activity by inhibiting histone acetyltransferase (HAT), thereby potentially protecting against nonalcoholic fatty liver disease (NAFLD) in cell and animal models.

JOURNAL OF MEDICINAL FOOD (2021)

Review Gastroenterology & Hepatology

Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests

Mojgan Masoodi et al.

Summary: Metabolomics and lipidomics approaches are utilized to identify biomarkers for NAFLD, with significant contributions in clinical studies; key metabolic pathway alterations in NAFLD and NASH have been identified, potentially serving as biomarkers for non-invasive diagnostic tests. Despite the discovery of potential biomarkers, few have been validated for clinical use.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Review Endocrinology & Metabolism

Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease: a systematic review and meta-analysis

Nader Salari et al.

Summary: This meta-analysis suggests that individuals with CC genotype have a 52% lower chance of developing non-alcoholic fatty liver disease, while those with CG genotype have a 19% higher risk and those with GG genotype have a 105% higher risk. Furthermore, individuals with CG + GG genotypes combined are 88% more likely to have NAFLD.

BMC ENDOCRINE DISORDERS (2021)

Review Nutrition & Dietetics

Effect of Dietary Fatty Acids on MicroRNA Expression Related to Metabolic Disorders and Inflammation in Human and Animal Trials

Karla MacDonald-Ramos et al.

Summary: Dietary fatty acids play crucial roles in metabolic diseases and inflammation, with diverse effects on miRNA expression. Recent studies have shown that high fat ketogenic diets do not increase saturated fat content in the serum and are not associated with increased inflammation. Further research is needed to explore the complex interactions and potential therapeutic applications of DFAs.

NUTRIENTS (2021)

Article Microbiology

Metabolomic Predictors of Non-alcoholic Steatohepatitis and Advanced Fibrosis in Children

Kattayoun Kordy et al.

Summary: The study found that children with more severe liver pathology in non-alcoholic fatty liver disease had more dysbiosis in their microbiota and disturbances in various metabolic pathways. Non-targeted mass spectrometry analysis revealed metabolic perturbations in one-carbon metabolism, mitochondrial dysfunction, and oxidative stress in these children.

FRONTIERS IN MICROBIOLOGY (2021)

Review Biochemistry & Molecular Biology

Dietary Patterns Influence Target Gene Expression through Emerging Epigenetic Mechanisms in Nonalcoholic Fatty Liver Disease

Mohamed Zaiou et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the accumulation of fat in liver cells, increasingly becoming the leading cause of metabolic disorders linked with genetics, lifestyle, diet, and microbiota. Epigenetic processes play a key role in gene expression and NAFLD pathogenesis. Research suggests innovative epigenetic-based strategies for early prevention and treatment of NAFLD.

BIOMEDICINES (2021)

Article Microbiology

Comparative Analysis of 16S rRNA Gene and Metagenome Sequencing in Pediatric Gut Microbiomes

Danielle Peterson et al.

Summary: This study compared the effects of profiling the human infant gut microbiome with 16S rRNA amplicon vs. shotgun metagenomic sequencing techniques, finding that changes in diversity with age were similar using both methods, and that 16S rRNA profiling identified a larger number of genera.

FRONTIERS IN MICROBIOLOGY (2021)

Review Gastroenterology & Hepatology

Omega-3 Fatty Acids and Gut Microbiota: A Reciprocal Interaction in Nonalcoholic Fatty Liver Disease

Samaa Shama et al.

DIGESTIVE DISEASES AND SCIENCES (2020)

Editorial Material Gastroenterology & Hepatology

Redefining non-alcoholic fatty liver disease: what's in a name?

[Anonymous]

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Biochemistry & Molecular Biology

Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modification of the Nrf2 signaling pathway

Hossein Hosseini et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Nutrition and Genetics in NAFLD: The Perfect Binomium

Marica Meroni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Nutrition & Dietetics

A Low ω-6 to ω-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth

Michelle A. Van Name et al.

JOURNAL OF NUTRITION (2020)

Article Biochemistry & Molecular Biology

miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload

Li Wang et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

Review Endocrinology & Metabolism

Genetic and epigenetic factors determining NAFLD risk

Wenke Jonas et al.

MOLECULAR METABOLISM (2020)

Review Gastroenterology & Hepatology

Metabolic associated fatty liver disease: Addressing a new era in liver transplantation

Madeleine G. Gill et al.

WORLD JOURNAL OF HEPATOLOGY (2020)

Article Nutrition & Dietetics

Fish intake interacts with TM6SF2 gene variant to affect NAFLD risk: results of a case-control study

I. P. Kalafati et al.

EUROPEAN JOURNAL OF NUTRITION (2019)

Article Biochemistry & Molecular Biology

Down-Regulation of SIRT1 Expression by mir-23b Contributes to Lipid Accumulation in HepG2 Cells

Mohammad Borji et al.

BIOCHEMICAL GENETICS (2019)

Article Pharmacology & Pharmacy

Characterization of Vitamin A Metabolome in Human Livers With and Without Nonalcoholic Fatty Liver Disease

Guo Zhong et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

Review Chemistry, Medicinal

Effects of Fish n-3 PUFAs on Intestinal Microbiota and Immune System

Cinzia Parolini

MARINE DRUGS (2019)

Review Food Science & Technology

Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective

Guan Yang et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

Article Gastroenterology & Hepatology

Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity

Alissa C. Nicolucci et al.

GASTROENTEROLOGY (2017)

Review Biochemistry & Molecular Biology

Impact of Omega-3 Fatty Acids on the Gut Microbiota

Lara Costantini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Gut Microbiota and Lifestyle Interventions in NAFLD

David Houghton et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Gastroenterology & Hepatology

The role of the gut microbiota in NAFLD

Christopher Leung et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2016)

Article Endocrinology & Metabolism

Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene

Nicola Santoro et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Article Gastroenterology & Hepatology

Metabolomic tissue signature in human non-alcoholic fatty liver disease identifies protective candidate metabolites

Witigo von Schoenfels et al.

LIVER INTERNATIONAL (2015)

Review Endocrinology & Metabolism

Foodomics for healthy nutrition

Alessandra Bordoni et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2014)

Editorial Material Nutrition & Dietetics

Nutrimetabolomics

Monique J. LeMieux et al.

ADVANCES IN NUTRITION (2014)

Article Nutrition & Dietetics

Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

Ksenia Sevastianova et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2012)

Article Nutrition & Dietetics

Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans

Ksenia Sevastianova et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2011)

Review Endocrinology & Metabolism

The environment within: how gut microbiota may influence metabolism and body composition

A. Vrieze et al.

DIABETOLOGIA (2010)

Article Gastroenterology & Hepatology

Fructose consumption as a risk factor for non-alcoholic fatty liver disease

Xiaosen Ouyang et al.

JOURNAL OF HEPATOLOGY (2008)