Suicide-Related Single Nucleotide Polymorphisms, rs4918918 and rs10903034: Association with Dementia in Older Adults

Dementia has enormous implications for patients and the health care system. Genetic markers are promising for detecting the risk of cognitive impairment. We hypothesized that genetic variants associated with suicide risk might significantly increase the risk of cognitive decline because suicide in older adults is often a consequence of cognitive impairment. We investigated several single-nucleotide polymorphisms that were initially associated with suicide risk in dementia older adults and identified the APOE gene alleles. The study was performed with subjects over the age of 65: 112 patients with dementia and 146 healthy volunteers. The MMSE score was used to assess cognitive functions. Study participants were genotyped using real-time PCR (APOE: rs429358, rs7412; genes associated with suicide: rs9475195, rs7982251, rs2834789, rs358592, rs4918918, rs3781878, rs10903034, rs165774, rs16841143, rs11833579 rs10898553, rs7296262, rs3806263, and rs2462021). Genotype analysis revealed the significance of APOE epsilon 4, APOE epsilon 2, and rs4918918 (SORBS1) when comparing dementia and healthy control groups. The association of APOE epsilon 4, APOE epsilon 2, and rs10903034 (IFNLR1) with the overall MMSE score was indicated. The study found an association with dementia of rs4918918 (SORBS1) and rs10903034 (IFNLR1) previously associated with suicide and confirmed the association of APOE epsilon 4 and APOE epsilon 2 with dementia.

Automated summary

Dementia has significant implications for patients and the healthcare system. This study investigates the potential link between genetic variants associated with suicide risk and the risk of cognitive decline in older adults. The results suggest that certain genetic markers, including APOE epsilon 4 and APOE epsilon 2, are associated with an increased risk of dementia.