4.6 Review

The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism

Journal

FRONTIERS IN PHYSIOLOGY
Volume 13, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2022.1040809

Keywords

myokines; AMPK; skeletal muscle; cell signalling; glucose metabolism; lipid metabolism

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Funding

  1. Natural Sciences and Engineering Research Council of Canada (NSERC) [2015-06263]
  2. La Societe Francophone du Diabete
  3. Fonds de Recherche du Quebec - Sante (FRQS)
  4. Institut du Savoir Montfort

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Myokines are peptides and proteins secreted by skeletal muscle cells, which can influence energy metabolism via AMPK signalling. Understanding how Myokines affect AMPK signalling and their mutual influence is important for better elucidation of metabolic regulation during exercise and at rest. This review covers the latest research on the relationship between AMPK signalling and Myokines within skeletal muscles.
Myokines are peptides and proteins secreted by skeletal muscle cells, into the interstitium, or in the blood. Their regulation may be dependent or independent of muscle contraction to induce a variety of metabolic effects. Numerous myokines have been implicated in influencing energy metabolism via AMP-activated protein kinase (AMPK) signalling. As AMPK is centrally involved in glucose and lipid metabolism, it is important to understand how myokines influence its signalling, and vice versa. Such insight will better elucidate the mechanism of metabolic regulation during exercise and at rest. This review encompasses the latest research conducted on the relationship between AMPK signalling and myokines within skeletal muscles via autocrine or paracrine signalling.

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