Relationship between miRNA and ferroptosis in tumors

Article Dentistry, Oral Surgery & Medicine

EZH2-mediated SLC7A11 upregulation via miR-125b-5p represses ferroptosis of TSCC

Yue Yu et al.

Summary: This study reveals the important role of EZH2 in inhibiting ferroptosis in TSCC cells by inhibiting miR-125b-5p and enhancing SLC7A11.

ORAL DISEASES (2023)

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Article Oncology

Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma

Yuanjun Lu et al.

Summary: Our study reveals that the ETS1/miR-23a-3p/ACSL4 axis contributes to sorafenib resistance in HCC by regulating ferroptosis. This suggests that miR-23a-3p could be a potential target for improving sorafenib responsiveness in HCC patients.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Biochemistry & Molecular Biology

MiR-15a-3p regulates ferroptosis via targeting glutathione peroxidase GPX4 in colorectal cancer

Liurong Liu et al.

Summary: miR-15a-3p positively regulates ferroptosis in CRC by targeting GPX4, leading to increased levels of reactive oxygen species and malondialdehyde accumulation with overexpression, while reducing sensitivity to erastin and GPX4 with suppression.

MOLECULAR CARCINOGENESIS (2022)

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Article Oncology

Silencing lncRNA SLC16A1-AS1 Induced Ferroptosis in Renal Cell Carcinoma Through miR-143-3p/SLC7A11 Signaling

Yan Ze Li et al.

Summary: In this study, it was revealed that silencing lncRNA SLC16A1-AS1 can induce ferroptosis through miR-143-3p/SLC7A11 signaling pathway in renal cancer. The results provided a novel view into the pathogenesis and treatment strategy of RCC.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2022)

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Article Oncology

MicroRNA-15a promotes prostate cancer cell ferroptosis by inhibiting GPX4 expression

Po Xu et al.

Summary: This study found that miR-15a induces ferroptosis by regulating GPX4 in prostate cancer cells. Transfection with miR-15a mimics or si-GPX4 suppressed cell proliferation and increased cell death and ROS accumulation. These findings provide important insights for the investigation of therapeutic strategies for prostate cancer.

ONCOLOGY LETTERS (2022)

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Article Cell Biology

MicroRNA-214-3p aggravates ferroptosis by targeting GPX4 in cisplatin-induced acute kidney injury

Junran Zhou et al.

Summary: This study investigates the biological function of miR-214-3p in cisplatin-induced AKI and uncovers its role in regulating TEC ferroptosis via GPX4. Inhibiting miR-214-3p can alleviate cisplatin-induced renal tubular injury by suppressing TEC ferroptosis.

CELL STRESS & CHAPERONES (2022)

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Article Cell Biology

Downregulation of HULC Induces Ferroptosis in Hepatocellular Carcinoma via Targeting of the miR-3200-5p/ATF4 Axis

Lulu Guan et al.

Summary: This study found that knockdown of HULC increases ferroptosis and oxidative stress in liver cancer cells. They also identified changes in certain miRNAs in cells treated with HULC siRNA, with HULC acting as a ceRNA of miR-3200-5p. miR-3200-5p regulates ferroptosis by targeting ATF4, leading to the inhibition of proliferation and metastasis in HCC cells.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Pathology

MiR-34c-3p upregulates erastin-induced ferroptosis to inhibit proliferation in oral squamous cell carcinomas by targeting SLC7A11

Kai Sun et al.

Summary: miR-34c-3p is downregulated in OSCC and its overexpression inhibits cell proliferation while promoting ferroptosis by increasing ROS, MDA, and iron levels and decreasing GSH and GPX4 levels.

PATHOLOGY RESEARCH AND PRACTICE (2022)

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Article Oncology

MicroRNA-4735-3p Facilitates Ferroptosis in Clear Cell Renal Cell Carcinoma by Targeting SLC40A1

Cairong Zhu et al.

Summary: miR-4735-3p expression is reduced in ccRCC, but elevated upon ferroptotic stimulation. miR-4735-3p promotes ferroptosis and tumor suppression in ccRCC by targeting SLC40A1.

ANALYTICAL CELLULAR PATHOLOGY (2022)

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Article

MiR-375-3p Promotes Cardiac Fibrosis by Regulating the Ferroptosis Mediated by GPX4

Yu Zhuang et al.

Computational Intelligence and Neuroscience (2022)

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Article Medicine, Research & Experimental

miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways

Guoshu Bi et al.

Summary: The study identified miR-6077 as a key driver of cisplatin/pemetrexed resistance in lung adenocarcinoma (LUAD). Overexpression of miR-6077 desensitized LUAD cells to cisplatin/pemetrexed by affecting cell cycle and ferroptosis, leading to cell death. This research provides a novel therapeutic strategy for overcoming chemoresistance in clinical practice.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA ADAMTS9-AS1 attenuates ferroptosis by Targeting microRNA-587/solute carrier family 7 member 11 axis in epithelial ovarian cancer

Li Cai et al.

Summary: This study found that ADAMTS9-AS1 attenuates ferroptosis in EOC by targeting the miR-587/SLC7A11 axis, thereby inhibiting proliferation and migration of EOC cells. This research provides a new therapeutic target for EOC.

BIOENGINEERED (2022)

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Article Biotechnology & Applied Microbiology

MiR-19a suppresses ferroptosis of colorectal cancer cells by targeting IREB2

Hongwei Fan et al.

Summary: Research has found that miR-19a promotes the proliferation, migration, and invasion of colorectal cancer cells. It has been discovered that miR-19a suppresses ferroptosis by negatively regulating IREB2. This finding reveals a novel mechanism of miR-19a-mediated ferroptosis in CRC.

BIOENGINEERED (2022)

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Article Genetics & Heredity

Novel Immune-Related Ferroptosis Signature in Esophageal Cancer: An Informatics Exploration of Biological Processes Related to the TMEM161B-AS1/hsa-miR-27a-3p/GCH1 Regulatory Network

Min Lu et al.

Summary: In this study, a prognostic model of differential expressed immune-related ferroptosis genes was constructed and the ferroptosis-related biological processes in esophageal cancer were explored. The model showed high predictive value and enrichment of biological functions and pathways related to immunity and ferroptosis in the high-risk group. The TMEM161B-AS1/hsa-miR-27a-3p/GCH1 network was found to play a role in esophageal cancer progression, and KMT2D mutation was associated with risk score and SLC2A3 expression.

FRONTIERS IN GENETICS (2022)

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Article Oncology

TFAP2C-Mediated lncRNA PCAT1 Inhibits Ferroptosis in Docetaxel-Resistant Prostate Cancer Through c-Myc/miR-25-3p/SLC7A11 Signaling

Xingkang Jiang et al.

Summary: PCAT1 is highly expressed in docetaxel-resistant prostate cancer cells and inhibits ferroptosis by activating SLC7A11 expression, thereby increasing docetaxel resistance. PCAT1 interacts with c-Myc and competes for microRNA-25-3p to transcriptionally promote SLC7A11 expression. Transcription factor TFAP2C activates PCAT1 expression to reduce ferroptosis susceptibility and enhance chemoresistance in prostate cancer.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Circular RNA circLMO1 Suppresses Cervical Cancer Growth and Metastasis by Triggering miR-4291/ACSL4-Mediated Ferroptosis

Rongying Ou et al.

Summary: The study demonstrated that circLMO1 acts as a tumor suppressor in cervical cancer by down-regulating miR-4291/ACSL4-mediated ferroptosis, providing a potential biomarker for clinical management of cervical cancer. CircLMO1 overexpression inhibited cervical cancer cell proliferation and invasion, while depletion promoted these processes. CircLMO1 functions as a competing endogenous RNA by interacting with miR-4192 and ACSL4 to regulate cervical cancer development.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

CircP4HB regulates ferroptosis via SLC7A11-mediated glutathione synthesis in lung adenocarcinoma

Chun-Feng Pan et al.

Summary: This study reveals that circP4HB acts as a ferroptosis suppressor in lung adenocarcinoma (LUAD) by modulating the miR-1184/SLC7A11 axis, providing a potential biomarker for LUAD diagnosis and treatment.

TRANSLATIONAL LUNG CANCER RESEARCH (2022)

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Article Plant Sciences

Icariside II induces ferroptosis in renal cell carcinoma cells by regulating the miR-324-3p/GPX4 axis

Rui Yu et al.

Summary: The flavonoid Icariside II (ICS II) has been found to inhibit the proliferation, migration, and invasion of renal cell carcinoma (RCC) cells. This study demonstrated that ICS II induces a form of cell death called ferroptosis in RCC cells, which is accompanied by increased levels of Fe2+, MDA, and ROS, as well as decreased levels of GSH. The underlying mechanism involves the downregulation of GPX4 and the upregulation of miR-324-3p, which directly targets GPX4.

PHYTOMEDICINE (2022)

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Article Oncology

Nanoparticle delivery of miR-21-3p sensitizes melanoma to anti-PD-1 immunotherapy by promoting ferroptosis

Weinan Guo et al.

Summary: The upregulation of miR-21-3p contributes to IFN-gamma-driven ferroptosis and synergizes with anti-PD-1 antibody. Nanoparticle delivery of miR-21-3p is a promising therapeutic approach to increase immunotherapy efficacy without obvious systemic side effects.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Engineering, Biomedical

Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis

Ruonan Zhang et al.

Summary: Curcumenol has been found to induce cell death and inhibit cell proliferation in lung cancer cells. The study also reveals that the long non-coding RNA H19 (lncRNA H19) is downregulated in lung cancer cells treated with curcumenol, and its decreased expression enhances curcumenol-induced ferroptotic cell death through the miR-19b-3p/FTH1 axis.

BIOACTIVE MATERIALS (2022)

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Article Oncology

LncRNA T-UCR Uc.339/miR-339/SLC7A11 Axis Regulates the Metastasis of Ferroptosis-Induced Lung Adenocarcinoma

Ning Zhang et al.

Summary: The progression of lung adenocarcinoma is closely related to the inhibition of ferroptosis. This study identified a Uc.339/miR-339/SLC7A11 axis regulated by LncRNA T-UCR Uc.339, which affects the expression of SLC7A11 and participates in tumor metastasis and development. The results suggest a potential mechanism that drives the metastasis of lung adenocarcinoma.

JOURNAL OF CANCER (2022)

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Article Cell Biology

miR-545 promotes colorectal cancer by inhibiting transferring in the non-normal ferroptosis signaling

Sixin Zheng et al.

Aging-US (2021)

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Article Cell Biology

Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis

Wen Xu et al.

Aging-US (2021)

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Article Oncology

SLC7A11/xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells

Poonam Yadav et al.

Summary: miR-5096 induces ferroptotic cell death in breast cancer cells by targeting and downregulating SLC7A11, reducing ROS, lipid peroxides, and iron accumulation levels, as well as decreasing GSH levels and mitochondrial membrane potential, inhibiting cell survival, migration, and invasion.

CANCER LETTERS (2021)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4

Zhengquan Xu et al.

Summary: miR-1287-5p promotes ferroptosis of osteosarcoma cells by inhibiting GPX4 and increases sensitivity to cisplatin chemotherapy, providing a new approach for the treatment of human osteosarcoma.

FREE RADICAL RESEARCH (2021)

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Article Cell Biology

CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression

Meiheban Bazhabayi et al.

Summary: CircRNAs play an important role in regulating HER-2-positive breast cancer, with circGFRA1 identified as a key player. CircGFRA1 binds to miR-1228 through the ceRNA mechanism, thereby modulating the expression of AIFM2 and impacting the progression of HER-2-positive breast cancer. This study suggests that circGFRA1 could be a novel and promising treatment option for HER-2-positive breast cancer.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer

Yifeng Hou et al.

Summary: Metformin induces ferroptosis in breast cancer cells by upregulating miR-324-3p, leading to decreased cancer cell viability. The drug promotes ferroptosis by targeting the miR-324-3p/GPX4 axis, suggesting its potential as an anti-cancer agent.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

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Article Cell Biology

Circular RNA circEPSTI1 accelerates cervical cancer progression via miR-375/409-3P/515-5p-SLC7A11 axis

Peng Wu et al.

Summary: In this study, circEPSTI1 was found to be significantly upregulated in cervical cancer and shown to impact cell ferroptosis. The circEPSTI1-miR-375/409-3P/515-5p-SLC7A11 axis was identified to affect proliferation in cervical cancer through the ceRNA mechanism and was linked to ferroptosis. The findings suggest circEPSTI1 as a potential new biomarker for monitoring and targeting treatment in cervical cancer.

AGING-US (2021)

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Article Cell Biology

Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer

Huiming Zhang et al.

Aging-US (2021)

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Article Cell Biology

Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells

Shazhou Ye et al.

Summary: CYGB plays a crucial role in ferroptosis by regulating ROS accumulation and impacting mitochondrial function. Overexpression of CYGB increases sensitivity of cancer cells to ferroptotic cell death, which is mediated through the p53-YAP1 axis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Cell Biology

Chemotoxicity-induced exosomal lncFERO regulates ferroptosis and stemness in gastric cancer stem cells

Haiyang Zhang et al.

Summary: Cancer stem cells are influenced by ferroptosis, a form of cell death involving iron ions and regulated by intracellular signals. The role of ferroptosis in tumor stem cells is crucial for understanding mechanisms of recurrence and drug resistance in cancers.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer

Jiawen Yang et al.

Summary: This study demonstrates that cetuximab enhances the cytotoxic effect of RSL3 on KRAS mutant CRC cells by regulating the p38/Nrf2/HO-1 axis to promote ferroptosis. These findings suggest a potential strategy to overcome drug resistance in KRAS mutant colorectal cancer.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer

Wenjie Luo et al.

Summary: The lncRNA RP11-89 promotes cell proliferation, migration, tumorigenesis and inhibits cell cycle arrest through the miR-129-5p/PROM2 axis in bladder cancer. RP11-89 acts as a sponge for miR-129-5p, upregulating PROM2 and activating iron export, leading to attenuation of ferroptosis. RP11-89 is a novel tumorigenic regulator that may serve as a potential biomarker for targeted therapy in bladder cancer.

CELL DEATH & DISEASE (2021)

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Article Oncology

miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities

Xinzhi Yang et al.

Summary: The study demonstrates that down-regulation of ALOXE3 in glioblastoma may contribute to resistance to ferroptosis and enhanced migration of cancer cells. Furthermore, miR-18a directly targets ALOXE3 to suppress its functions in glioblastoma cells, indicating potential for targeting the miR-18a/ALOXE3 axis as a therapeutic approach for glioblastoma treatment.

ONCOGENESIS (2021)

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Article Biochemistry & Molecular Biology

Nanomedicine promotes ferroptosis to inhibit tumour proliferation in vivo

Yifeng Luo et al.

Summary: miR-101?3p restores ferroptosis in tumor cells by targeting TBLR1, promoting apoptosis and inhibiting proliferation. Nanomedicine can deliver miR-101?3p to tumor cells for ferroptosis recovery, potentially serving as an effective therapy to inhibit tumor proliferation.

REDOX BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation

Jialei Sun et al.

Summary: QSOX1 acts as a cellular prooxidant in HCC, sensitizing cells to oxidative stress by inhibiting NRF2. There is a negative correlation between QSOX1 and NRF2 expression in tumor tissues from HCC patients, and QSOX1 can enhance sorafenib-induced ferroptosis.

REDOX BIOLOGY (2021)

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Article Oncology

MiR-21-5p Induces Pyroptosis in Colorectal Cancer via TGFBI

Rilei Jiang et al.

Summary: The study revealed that miR-21-5p induces pyroptosis in colorectal cancer through TGFBI regulation, providing important mechanistic insights and expanding its potential for clinical applications.

FRONTIERS IN ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549

Shi-hua Deng et al.

Summary: The study revealed that miR-324-3p reversed cisplatin resistance in A549/DDP cells by targeting the GPX4 gene, while also enhancing sensitivity to cisplatin-induced ferroptosis.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Oncology

Propofol induces ferroptosis and inhibits malignant phenotypes of gastric cancer cells by regulating miR-125b-5p/STAT3 axis

Yi-Ping Liu et al.

Summary: The study revealed that propofol inhibits proliferation, induces apoptosis, suppresses invasion and migration of gastric cancer cells. It induces ferroptosis by regulating the miR-125b-5p/STAT3 axis, suggesting its potential as a therapeutic candidate for gastric cancer.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

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Article Cell Biology

miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE

Yan Yang et al.

Summary: miR-539 regulates ferroptosis in CRC by activating the SAPK/JNK axis and affecting the expression of TIPE, providing a new insight into the treatment of CRC.

CELL DEATH DISCOVERY (2021)

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Review Biochemistry & Molecular Biology

The diverse functionality of NQO1 and its roles in redox control

David Ross et al.

Summary: This review summarizes the various roles of NQO1 in cell defense and cellular stress, as well as its potential roles in redox control. The interest in NQO1 lies in its inducibility during cellular stress and its involvement in redox processes. Both exogenous and endogenous substrates for NQO1 have been identified, with active research being conducted on compounds activated by NQO1 and NQO1-targeted drug delivery.

REDOX BIOLOGY (2021)

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Article Oncology

Ferroptosis is involved in the progression of hepatocellular carcinoma through the circ0097009/miR-1261/SLC7A11 axis

Ning Lyu et al.

Summary: In this study, circRNA circ0097009 was found to be significantly upregulated in HCC tissues and cell lines, and it acted as a competing endogenous RNA to regulate the expression of SLC7A11 by sponging miR-1261 in HCC. Circ0097009 may serve as a diagnostic biomarker for HCC and a potential therapeutic target for HCC treatment.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer

Wenkuan Chen et al.

Summary: The study revealed high expression of circKIF4A in papillary thyroid cancer, and knocking it down could suppress cancer cell growth and migration. CircKIF4A was found to promote tumor progression by regulating miR-1231 and GPX4 expression. Targeting circKIF4A may be a potential method for future treatment of papillary thyroid cancer.

AGING-US (2021)

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Article Pharmacology & Pharmacy

Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway

Yanjun Chen et al.

Summary: Astragalus polysaccharide (APS) demonstrated its ability to prevent ferroptosis in a murine model of experimental colitis and human Caco-2 cells by inhibiting the NRF2/HO-1 pathway.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

MicroRNA-670-3p suppresses ferroptosis of human glioblastoma cells through targeting ACSL4

Chong Bao et al.

Summary: The study demonstrates that miR-670-3p suppresses ferroptosis in human glioblastoma cells by targeting ACSL4, and inhibiting miR-670-3p may serve as an alternative or adjuvant strategy in the treatment of glioblastoma. Increased chemosensitivity to TMZ was observed in U87MG and A172 cells treated with miR-670-3p inhibitor, indicating a potential therapeutic effect.

FREE RADICAL RESEARCH (2021)

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Article Immunology

miR-194-5p down-regulates tumor cell PD-L1 expression and promotes anti-tumor immunity in pancreatic cancer

Chengzhi Wang et al.

Summary: High expression of miR-194-5p in pancreatic cancer patients is associated with a better survival rate and inhibits the expression of PD-L1. Overexpression of miR-194-5p suppresses the progression of pancreatic cancer, promotes the infiltration of CD8+ T cells in tumor immune microenvironments, and enhances IFN-gamma production of CD8+ T cells.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines

Kazuo Tomita et al.

Summary: The study found that miR-7-5p controls radioresistance by generating ROS, leading to ferroptosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis

Zhiyu Song et al.

Summary: The study revealed the role of exosomal miRNA miR-4443 in controlling cisplatin resistance in NSCLC, showing that miR-4443 confers cisplatin resistance by transferring through exosomes and enhances tumor growth by regulating the FSP1-mediated ferroptosis pathway. Additionally, METTL3 was identified as a direct target gene of miR-4443, providing insights into the therapeutic potential of targeting ferroptosis in NSCLC chemoresistance.

LIFE SCIENCES (2021)

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Article Cell Biology

Suppressive role of microRNA-130b-3p in ferroptosis in melanoma cells correlates with DKK1 inhibition and Nrf2-HO-1 pathway activation

Yangying Liao et al.

Summary: miR-130b-3p inhibits ferroptosis in melanoma cells by activating the Nrf2/HO-1 pathway through suppression of DKK1, highlighting its potential as a therapeutic target for melanoma treatment.

HUMAN CELL (2021)

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Article Cell & Tissue Engineering

MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis

Haiwei Ni et al.

Summary: The study revealed that miR-375 can reduce the stemness of gastric cancer cells by targeting SLC7A11 and triggering ferroptosis. The miR-375/SLC7A11 regulatory axis may serve as a potential therapeutic target to attenuate the stemness of gastric cancer cells.

STEM CELL RESEARCH & THERAPY (2021)

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Article Biochemistry & Molecular Biology

Icariin inhibits hypoxia/reoxygenation-induced ferroptosis of cardiomyocytes via regulation of the Nrf2/HO-1 signaling pathway

Xiu-Juan Liu et al.

Summary: Myocardial infarction is caused by plaque formation in arterial walls leading to decreased blood flow and myocardial injury due to hypoxia. Icariin (ICA) has been shown to protect against myocardial injury, specifically in H/R-induced ferroptosis of cardiomyocytes. The protective mechanism involves the activation of the Nrf2/HO-1 signaling pathway.

FEBS OPEN BIO (2021)

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Article Pharmacology & Pharmacy

Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer

Dan Sun et al.

Summary: Lidocaine has been shown to enhance ferroptosis and suppress cell proliferation, apoptosis, invasion, and migration in ovarian and breast cancer cells. By downregulating SLC7A11 expression through the miR-382-5p/SLC7A11 axis, lidocaine promotes ferroptosis in these cancer cells. Clinical studies are needed to further investigate the potential of lidocaine in treating ovarian and breast cancer.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Levobupivacaine Induces Ferroptosis by miR-489-3p/SLC7A11 Signaling in Gastric Cancer

Shun-Hong Mao et al.

Summary: Levobupivacaine induces ferroptosis of gastric cancer cells to repress cell growth by regulating the miR-489-3p/SLC7A11 axis.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Genetics & Heredity

CircDTL Functions as an Oncogene and Regulates Both Apoptosis and Ferroptosis in Non-small Cell Lung Cancer Cells

Wang Shanshan et al.

Summary: The study identified that circDTL is upregulated in NSCLC cells, and acts as an oncogene by promoting apoptosis and ferroptosis. The mechanism involves the circDTL/miR-1287-5p/GPX4 axis, where GPX4 inhibits both ferroptosis and apoptosis. Silencing circDTL increases the sensitivity of NSCLC cells to chemotherapeutic agents.

FRONTIERS IN GENETICS (2021)

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Article Endocrinology & Metabolism

Circular RNA Circ_0067934 Attenuates Ferroptosis of Thyroid Cancer Cells by miR-545-3p/SLC7A11 Signaling

Hui-Hui Wang et al.

Summary: The study revealed that circ_0067934 attenuated ferroptosis of thyroid cancer cells through miR-545-3p/SLC7A11 signaling, indicating its potential as a therapeutic target for thyroid cancer treatment.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Oncology

METTL3 increases cisplatin chemosensitivity of cervical cancer cells via downregulation of the activity of RAGE

Ruyi Li et al.

Summary: METTL3 overexpression in cervical cancer cells enhances sensitivity to cisplatin and inhibits tumor growth by downregulating RAGE expression.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Article Biochemistry & Molecular Biology

Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis

Yuan Yuan et al.

Summary: The study demonstrated that oxygen-glucose deprivation/reperfusion induces ferroptosis in neurons, and kaempferol protects neurons from ferroptosis by activating the Nrf2/SLC7A11/GPX4 signaling pathway, reducing lipid peroxidation accumulation.

BIOMOLECULES (2021)

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Review Medicine, Research & Experimental

Targeting iron metabolism in cancer therapy

Michael Morales et al.

Summary: Iron is crucial for cellular functions and human health, but excess iron can lead to oxidative DNA damage and cancer. Cancer cells are more dependent on iron than normal cells, making targeting iron metabolism in cancer cells an emerging and powerful therapeutic strategy.

THERANOSTICS (2021)

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Review Biochemistry & Molecular Biology

Ferroptosis: mechanisms and links with diseases

Hong-fa Yan et al.

Summary: Ferroptosis is a form of cell death that is iron-dependent and involves accumulation of lethal lipid species from lipid peroxidation. This review discusses the regulatory mechanisms of ferroptosis and its connections with iron, lipid, and cysteine metabolism pathways. Additionally, it explores the role of ferroptosis in diseases such as cancer, ischemia/reperfusion, Alzheimer's disease, and Parkinson's disease, and evaluates the potential therapeutic applications of ferroptosis inhibitors in clinical settings.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Oncology

Tumor suppressor miR-424-5p abrogates ferroptosis in ovarian cancer through targeting ACSL4

Lin-Lin Ma et al.

Summary: The study revealed that miR-424-5p negatively regulates ferroptosis by targeting ACSL4 in ovarian cancer cells, while high expression of ACSL4 sensitizes ovarian cancer cells to ferroptosis inducers.

NEOPLASMA (2021)

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Article Biochemistry & Molecular Biology

Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism

Po-Han Chen et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Article Cell Biology

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CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

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GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

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ACS CENTRAL SCIENCE (2020)

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CircIL4R facilitates the tumorigenesis and inhibits ferroptosis in hepatocellular carcinoma by regulating the miR-541-3p/GPX4 axis

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CELL BIOLOGY INTERNATIONAL (2020)

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被撤回的出版物: Downregulation of RKIP promotes radioresistance of nasopharyngeal carcinoma by activating NRF2/NQO1 axis via downregulating miR-450b-5p (Retracted article. See vol. 14, 2023)

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Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11

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MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells

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Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

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The induction of ferroptosis by impairing STAT3/Nrf2/GPx4 signaling enhances the sensitivity of osteosarcoma cells to cisplatin

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