Related references
Note: Only part of the references are listed.Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis
Nis Halland et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
SGK1, autophagy and cancer: an overview
Madiha Javeed Ghani
MOLECULAR BIOLOGY REPORTS (2022)
Discovery of Herbacetin as a Novel SGK1 Inhibitor to Alleviate Myocardial Hypertrophy
Shujing Zhang et al.
ADVANCED SCIENCE (2022)
Upregulation of serum and glucocorticoid-regulated kinase 1 (SGK1) ameliorates doxorubicin-induced cardiotoxic injury, apoptosis, inflammation and oxidative stress by suppressing glucose regulated protein 78 (GRP78)-mediated endoplasmic reticulum stress
Feng Wang et al.
BIOENGINEERED (2022)
SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity
Xiao Han et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2022)
SGK1 in Human Cancer: Emerging Roles and Mechanisms
Yiwen Sang et al.
FRONTIERS IN ONCOLOGY (2021)
Serum- and Glucocorticoid-Inducible Kinase 1 Promotes Alternative Macrophage Polarization and Restrains Inflammation through FoxO1 and STAT3 Signaling
Junling Ren et al.
JOURNAL OF IMMUNOLOGY (2021)
Targeting PI3K/Akt signal transduction for cancer therapy
Yan He et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)
Stress and cancer: mechanisms, significance and future directions
Anabel Eckerling et al.
NATURE REVIEWS CANCER (2021)
PO-322 exerts potent immunosuppressive effects in vitro and in vivo by selectively inhibiting SGK1 activity
Yi Lai et al.
BRITISH JOURNAL OF PHARMACOLOGY (2020)
Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases
Ines Maestro et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2020)
Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells
Yujian H. Yang et al.
CELL REPORTS (2020)
Targeting autophagy to overcome drug resistance: further developments
Haocai Chang et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)
The prospect of serum and glucocorticoid-inducible kinase 1 (SGK1) in cancer therapy: a rising star
Ruizhe Zhu et al.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2020)
Modulation of regulatory T cell function and stability by co-inhibitory receptors
Liliana E. Lucca et al.
NATURE REVIEWS IMMUNOLOGY (2020)
The pathogenicity of Th17 cells in autoimmune diseases
Keiko Yasuda et al.
SEMINARS IN IMMUNOPATHOLOGY (2019)
The role of sodium in modulating immune cell function
Nicola Wilck et al.
NATURE REVIEWS NEPHROLOGY (2019)
Competition for nutrients and its role in controlling immune responses
Nidhi Kedia-Mehta et al.
NATURE COMMUNICATIONS (2019)
Western Diet and the Immune System: An Inflammatory Connection
Anette Christ et al.
IMMUNITY (2019)
Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis
Lennard Y. W. Lee et al.
CLINICAL CANCER RESEARCH (2019)
The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation
Wenqiang Gan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)
Targeting the PI3K pathway in cancer: are we making headway?
Filip Janku et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2018)
SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells
Chuan Wu et al.
CELL REPORTS (2018)
Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
Rajesh Basnet et al.
ACTA PHARMACEUTICA SINICA B (2018)
SGK1-FoxO1 Signaling Pathway Mediates Th17/Treg Imbalance and Target Organ Inflammation in Angiotensin II-Induced Hypertension
Ya-Nan Du et al.
FRONTIERS IN PHYSIOLOGY (2018)
Development of a new analog of SGK1 inhibitor and its evaluation as a therapeutic molecule of colorectal cancer
Xuchun Liang et al.
JOURNAL OF CANCER (2017)
The impact of western Diet and Nutrients on the Microbiota and immune Response at Mucosal interfaces
Donjete Statovci et al.
FRONTIERS IN IMMUNOLOGY (2017)
Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders
Vassilios J. Bezzerides et al.
SCIENTIFIC REPORTS (2017)
SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway
Weiwei Liu et al.
BRITISH JOURNAL OF CANCER (2017)
PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
Pau Castel et al.
CANCER CELL (2016)
Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases
Israel Hanukoglu et al.
GENE (2016)
Serum and glucocorticoid kinase 1 promoted the growth and migration of non-small cell lung cancer cells
Yu Xiaobo et al.
GENE (2016)
SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells
Cristina Talarico et al.
ONCOTARGET (2016)
Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
Petter Brodin et al.
CELL (2015)
SI113, a Specific Inhibitor of the Sgk1 Kinase Activity that Counteracts Cancer Cell Proliferation
Lucia D'Antona et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)
The microbiota regulates type 2 immunity through RORγt+ T cells
Caspar Ohnmacht et al.
SCIENCE (2015)
Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]sulfonamides as Highly Active and Selective SGK1 Inhibitors
Nis Halland et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors
Eeva M. Sommer et al.
BIOCHEMICAL JOURNAL (2013)
Therapeutic potential of serum and glucocorticoid inducible kinase inhibition
Florian Lang et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2013)
Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth
Florian Lang et al.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (2013)
A complex issue on CD4+ T-cell subsets
Shuiping Jiang et al.
IMMUNOLOGICAL REVIEWS (2013)
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
Chuan Wu et al.
NATURE (2013)
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
Markus Kleinewietfeld et al.
NATURE (2013)
GLOBAL HEALTH Behavioral and Dietary Risk Factors for Noncommunicable Diseases
Majid Ezzati et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Akt inhibitors: mechanism of action and implications for anticancer therapeutics
Jaikrit Bhutani et al.
INFECTIOUS AGENTS AND CANCER (2013)
Low SGK1 Expression in Human Adrenocortical Tumors Is Associated with ACTH-Independent Glucocorticoid Secretion and Poor Prognosis
Cristina L. Ronchi et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)
Nedd4-2 and the regulation of epithelial sodium transport
Daniela Rotin et al.
FRONTIERS IN PHYSIOLOGY (2012)
EMD638683, a Novel SGK Inhibitor with Antihypertensive Potency
Teresa F. Ackermann et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2011)
Diet, gut microbiota and immune responses
Kendle M. Maslowski et al.
NATURE IMMUNOLOGY (2011)
Protective and pathogenic functions of macrophage subsets
Peter J. Murray et al.
NATURE REVIEWS IMMUNOLOGY (2011)
Regulation of the epithelial sodium channel (ENaC) by membrane trafficking
Michael B. Butterworth
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)
Hyperaldosteronism and altered expression of an SGK1-dependent sodium transporter in ZDF rats leads to salt dependence of blood pressure
Markus Resch et al.
HYPERTENSION RESEARCH (2010)
Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells
John J. O'Shea et al.
SCIENCE (2010)
Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors
Marlys Hammond et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Regulatory T cells and immune tolerance
Shimon Sakaguchi et al.
CELL (2008)
The Aggravating Mechanisms of Aldosterone on Kidney Fibrosis
Giuseppe Remuzzi et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
Mechanisms of ENaC regulation and clinical implications
Vivek Bhalla et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
Steroid hormone release as well as renal water and electrolyte excretion of mice expressing PKB/SGK-resistant GSK3
Krishna M. Boini et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2008)
Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP-PNP
Baoguang Zhao et al.
PROTEIN SCIENCE (2007)
IL-2 signals through Sgkl and inhibits proliferation and apoptosis in kidney cancer cells
Rosario Amato et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2007)
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo
Aaron M. Ring et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis
Aaron M. Ring et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel α
Wenzheng Zhang et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Metabolism-dependent mutagenicity of a compound containing a piperazinyl indazole motif: Role of a novel P450-mediated metabolic reaction involving a putative oxaziridine intermediate
Hao Chen et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2006)
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
Han You et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCα in an aldosterone-sensitive manner
Wenzheng Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3
V Bhalla et al.
MOLECULAR ENDOCRINOLOGY (2005)
The role of Nedd4/Nedd4-like dependant ubiquitylation in epithelial transport processes
SY Flores et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2003)
SGK1 regulation of epithelial sodium transport
D Pearce
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2003)
Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity
GL Firestone et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2003)
Crystal structure of an inactive Akt2 kinase domain
X Huang et al.
STRUCTURE (2003)
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation
M Frödin et al.
EMBO JOURNAL (2002)
The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
RM Biondi et al.
EMBO JOURNAL (2001)
Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin
N Perrotti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
A Brunet et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Share Paper
