4.7 Review

Multi-omics approaches for in-depth understanding of therapeutic mechanism for Traditional Chinese Medicine

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

HIT 2.0: an enhanced platform for Herbal Ingredients' Targets

Deyu Yan et al.

Summary: HIT 2.0 is a curated dataset focusing on Herbal Ingredients' Targets from PubMed literatures 2000-2020, hosting 10,031 compound-target activity pairs with quality indicators between 2208 targets and 1237 ingredients from more than 1250 reputable herbs.

NUCLEIC ACIDS RESEARCH (2022)

Review Pharmacology & Pharmacy

The Adverse Reactions of Lianhua Qingwen Capsule/Granule Compared With Conventional Drug in Clinical Application: A Meta-Analysis

Caiyun Hu et al.

Summary: This meta-analysis evaluates the safety profile of Lianhua Qingwen capsule/granule (LHQW) and shows that LHQW has a lower incidence of adverse reactions compared to conventional drugs. It also demonstrates the effectiveness of LHQW in reducing adverse reactions during the treatment of influenza. Additionally, LHQW shows a lower incidence of adverse reactions in various safety indexes.

FRONTIERS IN PHARMACOLOGY (2022)

Article Multidisciplinary Sciences

Decoding herbal materials of TCM preparations with the multi-barcode sequencing approach

Qi Yao et al.

Summary: With the development of high-throughput sequencing technology, the multi-barcode sequencing approach has been successfully used to identify biological ingredients in Traditional Chinese Medicine (TCM) preparations. In this study, the approach was applied to four representative TCM preparations, and the results showed good universality, sensitivity, and reliability in decoding the herbal materials in these preparations.

SCIENTIFIC REPORTS (2022)

Article Biotechnology & Applied Microbiology

Plant DNA barcoding necessitates marker-specific efforts to establish more comprehensive reference databases

Andreas Kolter et al.

Summary: Increasing sampling depth can improve species identification rates and reduce erroneous identification in plant DNA barcoding. ITS showed the highest identification rate and gain by increased sampling effort, making it the most suitable marker in the planning phase of barcode studies.

GENOME (2021)

Article Pharmacology & Pharmacy

Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening

Xiaofei Chen et al.

Summary: This study confirms the effectiveness of Lianhuaqingwen (LHQW) capsule in treating COVID-19 pneumonia, providing chemical and biochemical evidence for exploring its therapeutic effects based on human exposure to its components and pharmacological activities. It demonstrates the utility of the human exposure-based approach in identifying pharmaceutically active components in Chinese herb medicines.

ACTA PHARMACEUTICA SINICA B (2021)

Review Pharmacology & Pharmacy

Traditional Chinese Medicine Network Pharmacology in Cardiovascular Precision Medicine

Li Gao et al.

Summary: Cardiovascular disease is a major health concern with multifactorial pathogenesis. Precision medicine and traditional Chinese medicine offer personalized treatments, but the complex multi-target nature of TCM makes its mechanism challenging to elucidate. Network pharmacology proves useful in predicting the mechanism of action.

CURRENT PHARMACEUTICAL DESIGN (2021)

Article Biochemistry & Molecular Biology

HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine

ShuangSang Fang et al.

Summary: Pharmacotranscriptomics has been used to evaluate drug efficacy and discover new drug targets. In the field of traditional Chinese medicine (TCM), there is a growing trend towards high-throughput transcriptomic screens for molecular effects of herbs/ingredients. HERB is a database that integrates gene targets for TCM herbs/ingredients and modern drugs, supporting the modernization of TCM and rational drug discovery efforts.

NUCLEIC ACIDS RESEARCH (2021)

Review Plant Sciences

Chemical composition, quality control, pharmacokinetics, pharmacological properties and clinical applications of Fufang Danshen Tablet: A systematic review

Xuan Zeng et al.

Summary: Fufang Danshen Tablet is a typical traditional Chinese medicine formula for treating cardiovascular and cerebrovascular diseases, but there are also some issues. Future research should focus on improving quality control, clarifying functional mechanisms, and reconfirming clinical effectiveness and safety.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Universal barcoding regions, rbcL, matK and trnH-psbA do not discriminate Cinnamomum species in Sri Lanka

C. H. W. M. R. Bhagya Chandrasekara et al.

Summary: Cinnamomum genus comprises about 250 species worldwide, with C. verum being the most popular due to its culinary and medicinal uses. Sri Lanka is the largest producer of true cinnamon and is home to unique wild species. DNA identification and polymorphism analysis are crucial for conservation and utilization strategies.

PLOS ONE (2021)

Article Multidisciplinary Sciences

Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes

Brian D. Lehmann et al.

Summary: The study revealed differences in MHC-I expression among different subtypes of TNBC, with the mesenchymal subtype being able to restore MHC-I expression by inhibiting PRC2 subunits. This provides a rationale for using PRC2 inhibitors in PD-L1 negative mesenchymal tumors.

NATURE COMMUNICATIONS (2021)

Article Integrative & Complementary Medicine

Exploring biological basis of Syndrome differentiation in coronary heart disease patients with two distinct Syndromes by integrated multi-omics and network pharmacology strategy

Gaosong Wu et al.

Summary: This study investigated the biological basis of Syndrome differentiation in Traditional Chinese Medicine for Coronary Heart Disease. The results revealed significant metabolic pathway differences and potential biomarkers between patients with different Syndromes, as well as possible associations with comorbidities. This evidence-based strategy sheds light on translating TCM theory into the practice of precision medicine.

CHINESE MEDICINE (2021)

Article Chemistry, Multidisciplinary

Comprehensive Quality Assessment of Kaixin Powder by HPLC-DAD Quantification and HPLC-QTOF-MS/MS Confirmation

Binbin Wang et al.

Summary: A simple and accurate HPLC-DAD method was established and validated for the quantitative analysis of seven bioactive compounds in KXP, including the first quantification of DTU and DTR. The study provided a useful method for analyzing the major bioactive compounds in KXP and improving its quality assessment research.

ACS OMEGA (2021)

Article Multidisciplinary Sciences

Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids

Yifei Liu et al.

Summary: Chinese goldthread (Coptis chinensis) is an early-diverging eudicot plant with diverse medicinal applications. The high-quality genome assembly and annotation of C. chinensis revealed a single ancient whole-genome duplication event shared by the Ranunculaceae family. The study also highlighted the functional importance of CYP719 gene in diversifying protoberberine-type alkaloids.

NATURE COMMUNICATIONS (2021)

Review Pharmacology & Pharmacy

Traditional Chinese Medicine and Colorectal Cancer: Implications for Drug Discovery

Qiang Sun et al.

Summary: Traditional Chinese medicine (TCM) has been used for centuries as an important part of complementary and alternative medicine, particularly in the treatment of various diseases. However, the lack of understanding of active ingredients and mechanisms of TCM in combating diseases like colorectal cancer has hindered the development of clinical products and precision medicine in this field.

FRONTIERS IN PHARMACOLOGY (2021)

Review Pharmacology & Pharmacy

Development of the general chapters of the Chinese Pharmacopoeia 2020 edition: A review

Xinyi Xu et al.

Summary: The 2020 edition of the Chinese Pharmacopoeia, approved by the National Medical Products Administration and the National Health Commission, has improved general testing methods and guidelines, expanded the use of advanced analytical techniques, strengthened the testing methods for exogenous pollutants in traditional Chinese medicines, and better aligned technical requirements with international standards to ensure the safety and effectiveness of pharmaceuticals and enhance drug regulation in China.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2021)

Article Chemistry, Analytical

Analysis of antioxidants in Chrysanthemum indici flos by online gradient extraction and HPLC-FRAP

Weifeng Fan et al.

Summary: The study presents a rapid method for identifying antioxidants in Chrysanthemum indici flos, discovering multiple compounds with antioxidant activity, some of which were detected in the flower for the first time. Through this system, sample extraction and antioxidant identification can be completed in less than 45 minutes.

ANALYTICAL METHODS (2021)

Article Biochemistry & Molecular Biology

PubChem in 2021: new data content and improved web interfaces

Sunghwan Kim et al.

Summary: PubChem, a popular chemical information resource, has made substantial improvements in the past two years by adding data from over 100 new sources, updating its homepage and record pages, introducing new services like the Periodic Table and Pathway pages, and creating a special data collection related to COVID-19 and SARS-CoV-2 in response to the pandemic.

NUCLEIC ACIDS RESEARCH (2021)

Review Integrative & Complementary Medicine

Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

Ting-ting Luo et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2020)

Review Food Science & Technology

Hypoglycemic effects of bioactive ingredients from medicine food homology and medicinal health food species used in China

Xue Gong et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

Letter Pharmacology & Pharmacy

Traditional Chinese medicine for COVID-19 treatment

Jun-Ling Ren et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Pharmacology & Pharmacy

Traditional Chinese Medicine and Gut Microbiome: Their Respective and Concert Effects on Healthcare

Runzhi Zhang et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Pharmacology & Pharmacy

Berberine pharmacology and the gut microbiota: A hidden therapeutic link

Solomon Habtemariam

PHARMACOLOGICAL RESEARCH (2020)

Article Pharmacology & Pharmacy

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

Li Runfeng et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Multidisciplinary Sciences

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)

Yifei Zhang et al.

NATURE COMMUNICATIONS (2020)

Article Engineering, Multidisciplinary

The Scientific Foundation of Chinese Herbal Medicine against COVID-19

Elaine Lai-Han Leung et al.

ENGINEERING (2020)

Article Medicine, Research & Experimental

Berberine alleviates type 2 diabetic symptoms by altering gut microbiota and reducing aromatic amino acids

Ye Yao et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Biology

Trends in herbgenomics

Tianyi Xin et al.

SCIENCE CHINA-LIFE SCIENCES (2019)

Review Cell Biology

The Role of Traditional Chinese Medicine in the Regulation of Oxidative Stress in Treating Coronary Heart Disease

Xinyu Yang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Pharmacology & Pharmacy

Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment

Runzhi Zhang et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

The Need for Multi-Omics Biomarker Signatures in Precision Medicine

Michael Olivier et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Integrative & Complementary Medicine

Exploring the Pharmacological Mechanism of the Herb Pair HuangLian-GanJiang against Colorectal Cancer Based on Network Pharmacology

Benjiao Gong et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

Article Biochemistry & Molecular Biology

ChEMBL: towards direct deposition of bioassay data

David Mendez et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemical Research Methods

Precision medicine needs pioneering clinical bioinformaticians

Gonzalo Gomez-Lopez et al.

BRIEFINGS IN BIOINFORMATICS (2019)

Article Biochemistry & Molecular Biology

TCMID 2.0: a comprehensive resource for TCM

Lin Huang et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

DrugBank 5.0: a major update to the DrugBank database for 2018

David S. Wishart et al.

NUCLEIC ACIDS RESEARCH (2018)

Review Integrative & Complementary Medicine

Systems biology approaches in the study of Chinese herbal formulae

Fei-Fei Cai et al.

CHINESE MEDICINE (2018)

Article Endocrinology & Metabolism

Role of omentin 1 and IL-6 in type 2 diabetes mellitus patients with diabetic nephropathy

Gandhipuram Periyasamy Senthilkumar et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2018)

Article Gastroenterology & Hepatology

Global patterns and trends in colorectal cancer incidence and mortality

Melina Arnold et al.

Review Chemistry, Medicinal

Network-based Approaches in Pharmacology

Baptiste Boezio et al.

MOLECULAR INFORMATICS (2017)

Article Reproductive Biology

Metabolism disrupting chemicals and metabolic disorders

Jerrold J. Heindel et al.

REPRODUCTIVE TOXICOLOGY (2017)

Article Multidisciplinary Sciences

TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations

Run-zhi Zhang et al.

SCIENTIFIC REPORTS (2017)

Review Medicine, General & Internal

Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia

Almudena Areosa Sastre et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2017)

Article Pharmacology & Pharmacy

Diabetes and Complications: Cellular Signaling Pathways, Current Understanding and Targeted Therapies

Krishna A. Adeshara et al.

CURRENT DRUG TARGETS (2016)

Review Chemistry, Medicinal

Research progress on berberine with a special focus on its oral bioavailability

Chang-Shun Liu et al.

FITOTERAPIA (2016)

Review Plant Sciences

Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs?

Feng Chen et al.

JOURNAL OF ETHNOPHARMACOLOGY (2016)

Review Multidisciplinary Sciences

Building the foundation for genomics in precision medicine

Samuel J. Aronson et al.

NATURE (2015)

Editorial Material Medicine, General & Internal

Precision Medicine - Personalized, Problematic, and Promising

J. Larry Jameson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Gastroenterology & Hepatology

Application of metagenomics in the human gut microbiome

Wei-Lin Wang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

Article Multidisciplinary Sciences

Transforming berberine into its intestine-absorbable form by the gut microbiota

Ru Feng et al.

SCIENTIFIC REPORTS (2015)

Review Biotechnology & Applied Microbiology

A renaissance in herbal medicine identification: From morphology to DNA

Shilin Chen et al.

BIOTECHNOLOGY ADVANCES (2014)

Article Medicine, Research & Experimental

System of Matrix Metalloproteinases and Cytokine Secretion in Type 2 Diabetes Mellitus and Impaired Carbohydrate Tolerance Associated with Arterial Hypertension

I. V. Kologrivova et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2014)

Editorial Material Integrative & Complementary Medicine

Network Pharmacology in Traditional Chinese Medicine

Shao Li et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)

Review Plant Sciences

What is in a name? The need for accurate scientific nomenclature for plants

Diego Rivera et al.

JOURNAL OF ETHNOPHARMACOLOGY (2014)

Article Biochemistry & Molecular Biology

STITCH 4: integration of protein-chemical interactions with user data

Michael Kuhn et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Chemistry, Multidisciplinary

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

Jinlong Ru et al.

JOURNAL OF CHEMINFORMATICS (2014)

Article Biochemistry & Molecular Biology

TCMID: traditional Chinese medicine integrative database for herb molecular mechanism analysis

Ruichao Xue et al.

NUCLEIC ACIDS RESEARCH (2013)

Review Plant Sciences

Omic techniques in systems biology approaches to traditional Chinese medicine research: Present and future

Alessandro Buriani et al.

JOURNAL OF ETHNOPHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

HIT: linking herbal active ingredients to targets

Hao Ye et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Chemistry, Medicinal

Identification of Marker Compounds in Herbal Drugs on TLC with DART-MS

Hye Jin Kim et al.

ARCHIVES OF PHARMACAL RESEARCH (2010)

Article Plant Sciences

Broad-scale amplification of matK for DNA barcoding plants, a technical note

Luke T. Dunning et al.

BOTANICAL JOURNAL OF THE LINNEAN SOCIETY (2010)

Article Endocrinology & Metabolism

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

Hao Zhang et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2010)

Article Biology

Assessment of candidate plant DNA barcodes using the Rutaceae family

Luo Kun et al.

SCIENCE CHINA-LIFE SCIENCES (2010)

Review Chemistry, Medicinal

Inhibitors of translation initiation as cancer therapeutics

Lisa Lindqvist et al.

FUTURE MEDICINAL CHEMISTRY (2009)

Review Biochemical Research Methods

Sense and nonsense of high-temperature liquid chromatography

Sabine Heinisch et al.

JOURNAL OF CHROMATOGRAPHY A (2009)

Article Biochemistry & Molecular Biology

PubChem: a public information system for analyzing bioactivities of small molecules

Yanli Wang et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Multidisciplinary Sciences

A DNA barcode for land plants

Peter M. Hollingsworth et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

STITCH: interaction networks of chemicals and proteins

Michael Kuhn et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Plant Sciences

DNA barcoding in land plants:: evaluation of rbcL in a multigene tiered approach

S. G. Newmaster et al.

CANADIAN JOURNAL OF BOTANY-REVUE CANADIENNE DE BOTANIQUE (2006)

Article Biochemistry & Molecular Biology

DrugBank: a comprehensive resource for in silico drug discovery and exploration

David S. Wishart et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Biology

Deciphering amphibian diversity through DNA barcoding: chances and challenges

M Vences et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2005)

Review Integrative & Complementary Medicine

An Overview of Traditional Chinese Herbal Formulae and a Proposal of a New Code System for Expressing the Formula Titles

Yeong-Deug Yi et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2004)