Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.1071897
Keywords
ferroptosis; glioblastoma; ROS; GPx4; iron metabolism
Categories
Funding
- National Natural Science Foundation of China [81802504, 81872207]
- Medico-Engineering Cooperation Funds from University of Electronic Science and Technology of China [ZYGX2021YGLH221]
- Sichuan Provincial People's Hospital Young Talent Fund [2022QN07]
- Sichuan Science and Technology Program [2020JDJQ0067, 2020JDRC0118, 2021YJ0564, 2022YFH0005, 23GJHZ0211]
- Science and Technology Innovation Project of Chengdu, China [2021-YF05-00225-SN]
- Sichuan Medical Association [Q19037]
Ask authors/readers for more resources
This study reviews the role and mechanism of ferroptosis in glioblastoma, as well as the research status and progress on ferroptosis as a potential therapeutic target. The mechanism of ferroptosis is related to intracellular iron metabolism level, lipid peroxide content, and glutathione peroxidase 4 activity. While ferroptosis holds promise as a therapeutic target for glioblastoma, its relation to other apoptosis methods is poorly understood and methods of applying ferroptosis to drug-resistant tumors are insufficiently explored.
Ferroptosis is a newly identified form of cell death that differs from autophagy, apoptosis and necrosis, and its molecular characteristics include iron-dependent lipid reactive oxygen species accumulation, mitochondrial morphology changes, and membrane permeability damage. These characteristics are closely related to various human diseases, especially tumors of the nervous system. Glioblastoma is the most common primary malignant tumor of the adult central nervous system, and the 5-year survival rate is only 4%-5%. This study reviewed the role and mechanism of ferroptosis in glioblastoma and the research status and progress on ferroptosis as a potential therapeutic target. The mechanism of ferroptosis is related to the intracellular iron metabolism level, lipid peroxide content and glutathione peroxidase 4 activity. It is worth exploring how ferroptosis can be applied in disease treatment; however, the relation between ferroptosis and other apoptosis methods is poorly understood and methods of applying ferroptosis to drug-resistant tumors are insufficient. Ferroptosis is a promising therapeutic target for glioblastoma. In-depth studies of its mechanism of action in glioblastoma and applications for clinical treatment are expected to provide insights for glioblastoma patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available