4.7 Article

Origin, distribution, and function of three frequent coding polymorphisms in the gene for the human P2X7 ion channel

Related references

Note: Only part of the references are listed.
Editorial Material Biochemical Research Methods

Protein structure predictions to atomic accuracy with AlphaFold

John Jumper et al.

NATURE METHODS (2022)

Article Biochemistry & Molecular Biology

Ensembl 2022

Fiona Cunningham et al.

Summary: Ensembl is unique in its flexible infrastructure for access to genomic data and annotation. They have focused on expediting annotation of new assemblies via the Ensembl Rapid Release platform, with the greatest annual number of newly annotated genomes released. They also developed a new method for comparative analyses and annotated non-vertebrate eukaryotes for the first time.

NUCLEIC ACIDS RESEARCH (2022)

Review Biochemistry & Molecular Biology

Purinergic P2X7 Receptor: A Therapeutic Target in Amyotrophic Lateral Sclerosis

Andre D. J. Mckenzie et al.

Summary: This review summarizes the current understanding of amyotrophic lateral sclerosis (ALS), the role of purinergic P2X(7) receptor (P2X(7)R) in ALS, the current landscape of P2X(7)R antagonists, and their potential in preclinical ALS models.

ACS CHEMICAL NEUROSCIENCE (2022)

Article Biotechnology & Applied Microbiology

The role of the mitochondrial protein VDAC1 in inflammatory bowel disease: a potential therapeutic target

Ankit Verma et al.

Summary: Recent studies have shown that mitochondrial dysfunction and the overexpression of VDAC1 play a role in inflammatory bowel diseases. This study investigates the effects of VDAC1-interacting molecules on UC and suggests a novel approach for treating UC and other inflammatory/autoimmune diseases.

MOLECULAR THERAPY (2022)

Review Pharmacology & Pharmacy

Development and clinical translation of P2X7 receptor antagonists: A potential therapeutic target in coronary artery disease?

Elijah Genetzakis et al.

Summary: The P2X(7)R receptor plays a crucial role in inflammation and is associated with various pathological conditions. Despite initial promise, P2X(7)R antagonists failed to show therapeutic benefits in clinical trials for rheumatoid arthritis and Crohn's disease. Recent evidence suggests a potential connection between P2X(7)R and cardiovascular diseases, making it a therapeutic target for atherosclerosis. However, there are barriers to successful clinical translation of P2X(7)R antagonists.

PHARMACOLOGY & THERAPEUTICS (2022)

Review Hematology

P2X7 Receptors: An Untapped Target for the Management of Cardiovascular Disease

Brandon G. Shokoples et al.

Summary: Chronic low-grade inflammation is closely linked to cardiovascular diseases. Targeting the purinergic receptor P2X7, which mediates inflammation and cellular death, shows potential in mitigating cardiovascular conditions. Inhibiting P2X7 activation and IL-1 beta/IL-18 release may reduce cardiovascular disease severity and occurrence of adverse cardiac events.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Review Immunology

The potential involvement of P2X7 receptor in COVID-19 pathogenesis: A new therapeutic target?

Paulo A. F. Pacheco et al.

Summary: Research suggests that the pathogenesis of COVID-19 may involve a hyperinflammatory response, with the activation of cytokines such as IL-1β and the NLRP3 inflammasome. The recognition of extracellular ATP by the P2X7 receptor may be related to immune dysregulation caused by the SARS-CoV-2 infection.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2021)

Review Pharmacology & Pharmacy

P2X7 Receptor as a Potential Target for Major Depressive Disorder

Zeyi Huang et al.

Summary: Major depressive disorder (MDD) is a common mental disorder, and its development is primarily related to pathological changes in the brain. Investigations suggest that the P2X7 receptor may be a potential mechanism underlying MDD induced by chronic stress.

CURRENT DRUG TARGETS (2021)

Review Genetics & Heredity

P2X7 receptor: a critical regulator and potential target for breast cancer

Xiaodi Zhu et al.

Summary: The upregulation of P2X7 receptor in breast cancer can promote tumor cell invasion and migration, and new P2X7 receptor inhibitors show potential in inhibiting this process.

JOURNAL OF MOLECULAR MEDICINE-JMM (2021)

Review Biochemistry & Molecular Biology

The Purinergic P2X7 Receptor-NLRP3 Inflammasome Pathway: A New Target in Alcoholic Liver Disease?

Brendan Le Dare et al.

Summary: Alcohol consumption is closely associated with the development and progression of many non-communicable inflammatory diseases, particularly in the liver. Recent research suggests that Kupffer cells play a key role in the pathophysiology of alcoholic liver disease. Therefore, modulating purinergic signaling may represent a new approach for treating alcoholic liver disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Gastroenterology & Hepatology

Enteric nervous system and inflammatory bowel diseases: Correlated impacts and therapeutic approaches through the P2X7 receptor

Henrique Inhauser Riceti Magalhaes et al.

Summary: This review discusses the structural organization of the enteric nervous system and the effects of inflammatory bowel diseases, emphasizing cellular constituents and how therapeutic approaches through the P2X7 receptor can protect the functionality of the affected intestine.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Review Biochemistry & Molecular Biology

Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer

Matthew Drill et al.

Summary: The P2X7 receptor is a plasma membrane receptor responsible for sensing extracellular ATP, commonly expressed on immune cells and highly upregulated in various cancers. Activation of this receptor leads to the formation of a non-selective cation channel, playing a potential trophic role in tumorigenesis. The receptor's broad range of functions make it a potential therapeutic target for cancer treatment, with several P2X7 antagonist compounds currently in pre-clinical and clinical development.

PURINERGIC SIGNALLING (2021)

Editorial Material Neurosciences

Editorial: P2X7 as Common Therapeutic Target in Brain Diseases

Tobias Engel et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Review Pharmacology & Pharmacy

P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different diseases

Abtar Mishra et al.

Summary: The P2X7 receptor is a key player in various physiological processes and has been directly associated with several pathophysiological conditions. Understanding its structure and downstream signaling processes is considered a promising approach to alleviate the afflictions associated with disorders like cancer, diabetes, arthritis, tuberculosis, and inflammatory diseases.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

The P2X7 Receptor: A Promising Pharmacological Target in Diabetic Retinopathy

Matteo Tassetto et al.

Summary: Diabetes is a global emergency that imposes a heavy burden on patients, health systems, and society. Diabetic retinopathy is a common and serious complication of diabetes, strongly associated with the risk of adult blindness. Recent research has identified a role for uncontrolled increases in extracellular ATP and overactivation of the purinergic receptor P2X7 in the pathogenesis, offering new therapeutic options for diabetic retinopathy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

Review Medicine, Research & Experimental

P2X7 receptor acts as an efficient drug target in regulating bone metabolism system

Yutong Dong et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Neurosciences

P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases

Abraham J. Cisneros-Mejorado et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

Review Oncology

The P2X7 purinergic receptor: a potential therapeutic target for lung cancer

Qianqian Li et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2020)

Review Pharmacology & Pharmacy

The P2X7 receptor: a new therapeutic target in Alzheimer's disease

Peter Illes et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2019)

Review Immunology

P2X7 receptor: A potential therapeutic target for autoimmune diseases

Fan Cao et al.

AUTOIMMUNITY REVIEWS (2019)

Article Pharmacology & Pharmacy

P2X7 purinoceptor as a therapeutic target in muscular dystrophies

Dariusz C. Gorecki

CURRENT OPINION IN PHARMACOLOGY (2019)

Article Pharmacology & Pharmacy

Novel biologics targeting the P2X7 ion channel

Friedrich Koch-Nolte et al.

CURRENT OPINION IN PHARMACOLOGY (2019)

Article Pharmacology & Pharmacy

Targeting P2X4 and P2X7 receptors in multiple sclerosis

Maria Domercq et al.

CURRENT OPINION IN PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization

Alanna E. McCarthy et al.

Review Cell Biology

P2X7, a critical regulator and potential target for bone and joint diseases

Dehui Zeng et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Biochemistry & Molecular Biology

The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression

Geoffrey Burnstock et al.

PURINERGIC SIGNALLING (2018)

Review Pharmacology & Pharmacy

The P2X7 receptor: A main player in inflammation

Elena Adinolfi et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Review Medical Laboratory Technology

The P2X7 purinergic receptor: An emerging therapeutic target in cardiovascular diseases

Zhe Chen et al.

CLINICA CHIMICA ACTA (2018)

Review Pharmacology & Pharmacy

Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders

Anindya Bhattacharya

FRONTIERS IN PHARMACOLOGY (2018)

Review Chemistry, Multidisciplinary

P2RX7 Purinoceptor as a Therapeutic Target-The Second Coming?

Chris N. J. Young et al.

FRONTIERS IN CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

P2X7 Receptor: A Potential Therapeutic Target for Depression?

Jan M. Deussing et al.

TRENDS IN MOLECULAR MEDICINE (2018)

Review Chemistry, Medicinal

P2X7 receptor antagonists: a patent review (2010-2015)

Jin-Hee Park et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2017)

Review Immunology

The P2X7 Receptor in Infection and Inflammation

Francesco Di Virgilio et al.

IMMUNITY (2017)

Editorial Material Cell Biology

P2X7 receptor antagonism in amyotrophic lateral sclerosis

Ronald Sluyter et al.

NEURAL REGENERATION RESEARCH (2017)

Article Chemistry, Medicinal

The evolution of P2X7 antagonists with a focus on CNS indications

Jason C. Rech et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Article Cell Biology

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation

Welbeck Danquah et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Article Multidisciplinary Sciences

A global reference for human genetic variation

David M. Altshuler et al.

NATURE (2015)

Article Multidisciplinary Sciences

Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

Olivier Delaneau et al.

NATURE COMMUNICATIONS (2014)

Review Pharmacology & Pharmacy

The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease

Rachael Bartlett et al.

PHARMACOLOGICAL REVIEWS (2014)

Article Biochemical Research Methods

The 1000 Genomes Project: data management and community access

Laura Clarke et al.

NATURE METHODS (2012)

Review Pharmacology & Pharmacy

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

Nishkantha Arulkumaran et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2011)

Review Immunology

The MHC, disease and selection

John Trowsdale

IMMUNOLOGY LETTERS (2011)

Article Immunology

Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway

Sandra Hubert et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

Article Biochemistry & Molecular Biology

Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor

Pablo Pelegrin et al.

EMBO JOURNAL (2006)

Review Multidisciplinary Sciences

P2X receptors as cell-surface ATP sensors in health and disease

Baljit S. Khakh et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

BLAST: improvements for better sequence analysis

Jian Ye et al.

NUCLEIC ACIDS RESEARCH (2006)

Review Immunology

The P2X7 receptor:: A key player in IL-1 processing and release

Davide Ferrari et al.

JOURNAL OF IMMUNOLOGY (2006)

Article Multidisciplinary Sciences

Cryopyrin activates the inflammasome in response to toxins and ATP

S Mariathasan et al.

NATURE (2006)

Review Pharmacology & Pharmacy

Pathophysiology and therapeutic potential of purinergic signaling

G Burnstock

PHARMACOLOGICAL REVIEWS (2006)

Review Pharmacology & Pharmacy

Molecular properties of ATP-gated P2X receptor ion channels

C Vial et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2004)

Article Biochemistry & Molecular Biology

An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor

BJ Gu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemical Research Methods

Genescript: DNA sequence annotation pipeline

AK Hudek et al.

BIOINFORMATICS (2003)

Article Biochemistry & Molecular Biology

An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor

JS Wiley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region

ML Smart et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Cell Biology

Alerting and tuning the immune response by extracellular nucleotides

A la Sala et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2003)

Review Physiology

Molecular physiology of P2X receptors

RA North

PHYSIOLOGICAL REVIEWS (2002)

Article Biochemistry & Molecular Biology

A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor

BJ Gu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Altered cytokine production in mice lacking P2X7 receptors

M Solle et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Review Pharmacology & Pharmacy

Extracellular metabolism of ATP and other nucleotides

H Zimmermann

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2000)

Article Biochemistry & Molecular Biology

T-Coffee: A novel method for fast and accurate multiple sequence alignment

C Notredame et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)