4.7 Article

Prenatal stress induces a depressive-like phenotype in adolescent rats: The key role of TGF-β1 pathway

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Neuroadaptations and TGF-beta signaling: emerging role in models of neuropsychiatric disorders

Swarup Mitra et al.

Summary: Neuropsychiatric diseases are characterized by maladaptive behavioral plasticity, and precise cellular mediators have been difficult to pinpoint. Increasing knowledge on the role of the transforming growth factor (TGF-beta) family of proteins in regulating neuroadaptations is shedding light on the influence of TGF-beta signaling in neuropsychiatric disorders.

MOLECULAR PSYCHIATRY (2022)

Article Biochemistry & Molecular Biology

Architecture of the NADPH oxidase family of enzymes

Blessing C. Ogboo et al.

Summary: NADPH oxidases are important regulators of redox-dependent processes, and recent structural biology studies have provided insights into their molecular structure. It has been discovered that stabilization of intracellular domain-domain interactions plays a key role in controlling the catalytic activity of NOX enzymes.

REDOX BIOLOGY (2022)

Article Biochemistry & Molecular Biology

Stress Hormones Cortisol and Aldosterone, and Selected Markers of Oxidative Stress in Response to Long-Term Supplementation with Omega-3 Fatty Acids in Adolescent Children with Depression

Henrieta Oravcova et al.

Summary: Late childhood and adolescence are crucial periods of brain development vulnerable to environmental insults. This study aimed to test the effect of omega-3 fatty acid supplementation on stress hormone concentrations and daily rhythm in adolescents with depression, and explore the correlation between stress hormones and oxidative stress markers.

ANTIOXIDANTS (2022)

Review Neurosciences

Sucrose Preference Test as a Measure of Anhedonic Behavior in a Chronic Unpredictable Mild Stress Model of Depression: Outstanding Issues

Dmitrii D. Markov

Summary: Despite numerous studies, the etiological and pathophysiological mechanisms of depression are still poorly understood. Chronic unpredictable mild stress is the most commonly used model, while the sucrose preference test is commonly used for assessing anhedonia. However, the reproducibility of the model and the relationship between animal and human anhedonia need further investigation.

BRAIN SCIENCES (2022)

Article Psychiatry

Dentate gyrus activin signaling mediates the antidepressant response

Mark M. Gergues et al.

Summary: This study developed a method to assess treatment resistance in mice to antidepressants, revealing differences in expression of Activin signaling-related genes in the dentate gyrus (DG) between responders and non-responders to fluoxetine treatment. The findings suggest that targeted manipulations of DG can modify the behavioral response to fluoxetine bidirectionally, offering a new therapeutic avenue for more effective antidepressant treatments.

TRANSLATIONAL PSYCHIATRY (2021)

Article Pharmacology & Pharmacy

The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling

Annamaria Fidilio et al.

Summary: The study suggests that LP2, a dual-target MOPr/DOPr agonist, can attenuate mechanical allodynia induced by CCI through rescuing TGF-beta 1 signaling via DOPr activation in spinal microglia. The dual-target approach with LP2 may represent a novel pharmacological strategy to enhance the analgesic efficacy of MOPr agonists.

FRONTIERS IN PHARMACOLOGY (2021)

Article Psychiatry

Canonical TGF-β signaling regulates the relationship between prenatal maternal depression and amygdala development in early life

Anqi Qiu et al.

Summary: The study found that the canonical TGF-beta signaling pathway plays a modulatory role in linking prenatal maternal depressive symptoms and amygdala volumes from birth to 6 years of age, with genetic variants of TGF-beta RI being particularly important in this relationship.

TRANSLATIONAL PSYCHIATRY (2021)

Article Neurosciences

A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice

Sebastiano A. Torrisi et al.

Summary: The study introduces a novel translational animal model, the AIS model, which sheds light on the neurobiology of PTSD. Susceptible mice exhibit long-lasting hyperarousal and PTSD-like phenotypes, while resilient mice show normal behavior and phenotypes.

NEUROBIOLOGY OF STRESS (2021)

Article Biochemistry & Molecular Biology

Carnosine Protects Macrophages against the Toxicity of Aβ1-42 Oligomers by Decreasing Oxidative Stress

Giuseppe Caruso et al.

Summary: The study showed that carnosine can protect macrophages from cell death and apoptosis induced by Aβ 1-42 oligomers, decrease oxidative stress, enhance macrophage phagocytic activity, and rescue fractalkine receptor CX3CR1. These new findings support the therapeutic potential of carnosine in the context of AD pathology, highlighting its multimodal mechanism of action.

BIOMEDICINES (2021)

Article Food Science & Technology

Prenatal and breastfeeding exposure to low dose of diethylhexyl phthalate induces behavioral deficits and exacerbates oxidative stress in rat hippocampus

Soheila Safarpour et al.

Summary: The study showed that exposure of mothers to low doses of DEHP during pregnancy and lactation can lead to behavioral deficits in rat pups, especially affecting the working and spatial memory of male rats. Additionally, increased oxidative stress and decreased antioxidant activity were observed in the hippocampus of rats receiving low doses of DEHP.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Article Cell Biology

Exposure to Prenatal Stress Is Associated With an Excitatory/Inhibitory Imbalance in Rat Prefrontal Cortex and Amygdala and an Increased Risk for Emotional Dysregulation

Francesca Marchisella et al.

Summary: Epidemiological studies have shown that environmental insults and maternal stress during pregnancy increase the risk of several psychiatric disorders in the offspring. Converging lines of evidence from humans, as well as from rodent models, suggest that prenatal stress (PNS) interferes with fetal development, ultimately determining changes in brain maturation and function that may lead to the onset of neuropsychiatric disorders. From a molecular standpoint, transcriptional alterations are thought to play a major role in this context and may contribute to the behavioral phenotype by shifting the expression of genes related to excitatory and inhibitory (E/I) transmission balance. Nevertheless, the exact neurophysiological mechanisms underlying the enhanced vulnerability to psychopathology following PNS exposure are not well understood. In the present study, we used a model of maternal stress in rats to investigate the distal effects of PNS on the expression of genes related to glutamatergic and GABAergic neurotransmissions. We inspected two critical brain regions involved in emotion regulation, namely, the prefrontal cortex (PFC) and the amygdala (AMY), which we show to relate with the mild behavioral effects detected in adult rat offspring. We observed that PNS exposure promotes E/I imbalance in the PFC of adult males only, by dysregulating the expression of glutamatergic-related genes. Moreover, such an effect is accompanied by increased expression of the activity-dependent synaptic modulator gene Npas4 specifically in the PFC parvalbumin (PV)-positive interneurons, suggesting an altered regulation of synapse formation promoting higher PV-dependent inhibitory transmission and increased overall circuit inhibition in the PFC of males. In the AMY, PNS more evidently affects the transcription of GABAergic-related genes, shifting the balance toward inhibition. Collectively, our findings suggest that the E/I dysregulation of the PFC-to-AMY transmission may be a long-term signature of PNS and may contribute to increase the risk for mood disorder upon further stress.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Oxidative Stress Markers and Antioxidant Enzymes in Children and Adolescents with Depressive Disorder and Impact of Omega-3 Fatty Acids in Randomised Clinical Trial

Barbora Katrencikova et al.

Summary: Oxidative stress is believed to be involved in the pathophysiology of depressive disorder, with markers of oxidative stress increased and antioxidant protection decreased in pediatric and adolescent patients with DD. Supplementation with omega-3 fatty acids has been shown to reduce oxidative stress in these patients, suggesting a potential therapeutic intervention.

ANTIOXIDANTS (2021)

Review Biochemistry & Molecular Biology

Inflammation as the Common Biological Link Between Depression and Cardiovascular Diseases: Can Carnosine Exert a Protective Role?

Giuseppe Caruso et al.

CURRENT MEDICINAL CHEMISTRY (2020)

Article Neurosciences

Prenatal restraint stress impairs recognition memory in adult male and female offspring

Clarissa A. Moura et al.

ACTA NEUROPSYCHIATRICA (2020)

Article Biochemistry & Molecular Biology

Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine

Claudia G. Fresta et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Pharmacology & Pharmacy

Role of oxidative stress in depression

Shvetank Bhatt et al.

DRUG DISCOVERY TODAY (2020)

Article Biochemistry & Molecular Biology

Dihydrotanshinone, a Natural Diterpenoid, Preserves Blood-Retinal Barrier Integrity via P2X7 Receptor

Claudia Giuseppina Fresta et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Psychology, Developmental

Maternal neural reactivity during pregnancy predicts infant temperament

Rebecca J. Brooker et al.

INFANCY (2020)

Review Psychology, Multidisciplinary

Antidepressant Drugs and Physical Activity: A Possible Synergism in the Treatment of Major Depression?

Claudia Savia Guerrera et al.

FRONTIERS IN PSYCHOLOGY (2020)

Article Neurosciences

Transcriptional Signatures of Cognitive Impairment in Rat Exposed to Prenatal Stress

Annamaria Cattaneo et al.

MOLECULAR NEUROBIOLOGY (2019)

Review Neurosciences

Targeting Serotonin Transporters in the Treatment of Juvenile and Adolescent Depression

Melodi A. Bowman et al.

FRONTIERS IN NEUROSCIENCE (2019)

Review Endocrinology & Metabolism

Individual differences in inflammatory and oxidative mechanisms of stress-related mood disorders

L. S. Kalinichenko et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2019)

Editorial Material Pharmacology & Pharmacy

The Many Faces of Mitochondrial Dysfunction in Depression: From Pathology to Treatment

Giuseppe Caruso et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

beta-amyloid and Oxidative Stress: Perspectives in Drug Development

Giuseppe Caruso et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

Review Medicine, Research & Experimental

Neurobiology and consequences of social isolation stress in animal model-A comprehensive review

Faiza Mumtaz et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Pharmacology & Pharmacy

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target

Filippo Caraci et al.

PHARMACOLOGICAL RESEARCH (2018)

Review Psychiatry

Sex Differences in Vulnerability to Prenatal Stress: a Review of the Recent Literature

Susanna Sutherland et al.

CURRENT PSYCHIATRY REPORTS (2018)

Article Public, Environmental & Occupational Health

Prenatal maternal stress shapes children's theory of mind: the QF2011 Queensland Flood Study

G. Simcock et al.

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2017)

Article Biochemical Research Methods

Indirect detection of superoxide in RAW 264.7 macrophage cells using microchip electrophoresis coupled to laser-induced fluorescence

Richard P. S. de Campos et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2015)

Article Psychiatry

Maternal depression during pregnancy and offspring depression in adulthood: role of child maltreatment

Dominic T. Plant et al.

BRITISH JOURNAL OF PSYCHIATRY (2015)

Review Pharmacology & Pharmacy

The Long-Term Impact of Early Adversities on Psychiatric Disorders: Focus on Neuronal Plasticity

Alessia Luoni et al.

CURRENT PHARMACEUTICAL DESIGN (2015)

Article Multidisciplinary Sciences

A Meta-Analysis of Oxidative Stress Markers in Depression

Tao Liu et al.

PLOS ONE (2015)

Review Endocrinology & Metabolism

The Consequences of Early-Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations

S. Maccari et al.

JOURNAL OF NEUROENDOCRINOLOGY (2014)

Article Medicine, Research & Experimental

Grape seed extract attenuates arsenic-induced nephrotoxicity in rats

Jiangong Zhang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2014)

Article Medicine, General & Internal

Oxidative Stress and Major Depression

Ashutosh Bajpai et al.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2014)

Review Biochemistry & Molecular Biology

Severe Life Stress and Oxidative Stress in the Brain: From Animal Models to Human Pathology

Stefania Schiavone et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Article Endocrinology & Metabolism

Maternal Mood and Neuroendocrine Programming: Effects of Time of Exposure and Sex

K. Vedhara et al.

JOURNAL OF NEUROENDOCRINOLOGY (2012)

Article Medicine, General & Internal

Depression in adolescence

Anita Thapar et al.

LANCET (2012)

Review Neurosciences

Neurobiology of resilience

Scott J. Russo et al.

NATURE NEUROSCIENCE (2012)

Review Pharmacology & Pharmacy

Immune system to brain signaling: Neuropsychopharmacological implications

Lucile Capuron et al.

PHARMACOLOGY & THERAPEUTICS (2011)

Article Neurosciences

Object recognition memory and the rodent hippocampus

Nicola J. Broadbent et al.

LEARNING & MEMORY (2010)

Article Neurosciences

Involvement of NOX2 in the Development of Behavioral and Pathologic Alterations in Isolated Rats

Stefania Schiavone et al.

BIOLOGICAL PSYCHIATRY (2009)

Article Psychology, Developmental

Project ice storm: Prenatal maternal stress affects cognitive and linguistic functioning in 51/2-year-old children

David P. Laplante et al.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2008)

Review Neurosciences

Stress, depression, and neuroplasticity: A convergence of mechanisms

Christopher Pittenger et al.

NEUROPSYCHOPHARMACOLOGY (2008)

Article Medicine, Research & Experimental

Expression of isoforms of NADPH oxidase components in rat pancreatic islets

Yuji Uchizono et al.

LIFE SCIENCES (2006)

Review Psychiatry

Neurobiology of depression in children and adolescents

Gil Zalsman et al.

CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA (2006)

Review Psychology, Clinical

Implications of timing of maternal depressive symptoms for early cognitive and language development

Sara L. Sohr-Preston et al.

CLINICAL CHILD AND FAMILY PSYCHOLOGY REVIEW (2006)

Article Clinical Neurology

Th1, Th2, and Th3 cytokine alterations in major depression

AM Myint et al.

JOURNAL OF AFFECTIVE DISORDERS (2005)

Review Biochemistry & Molecular Biology

Oxygen free radicals and the systemic inflammatory response

D Closa et al.

IUBMB LIFE (2004)

Article Neurosciences

Corticostriatal brain-derived neurotrophic factor dysregulation in adult rats following prenatal stress

F Fumagalli et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2004)

Article Cell Biology

Making sense of latent TGFβ activation

JP Annes et al.

JOURNAL OF CELL SCIENCE (2003)

Review Biochemistry & Molecular Biology

Defining the actions of transforming growth factor beta in reproduction

WV Ingman et al.

BIOESSAYS (2002)