Journal
FRONTIERS IN NEUROSCIENCE
Volume 17, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2023.1108191
Keywords
exercise; Alzheimer's disease; dementia; intervention; neurofilament light; neurodegeneration
Categories
Ask authors/readers for more resources
This study aimed to investigate whether a 16-week aerobic exercise program could reduce serum NfL in patients with mild Alzheimer's disease. The results showed that the exercise intervention did not have a significant effect on neurodegeneration. Further studies are needed to explore other types and durations of exercise as well as other measures of neurodegeneration.
Introduction: Aerobic exercise has been shown to modify Alzheimer pathology in animal models, and in patients with multiple sclerosis to reduce neurofilament light (NfL), a biomarker of neurodegeneration.Objective: To investigate whether a 16-week aerobic exercise program was able to reduce serum NfL in patients with mild Alzheimer's disease (AD).Methods: This is a secondary analysis of data from the multi-center Preserving Cognition, Quality of Life, Physical Health, and Functional Ability in Alzheimer's disease: The Effect of Physical Exercise (ADEX) study. Participants were randomized to 16 weeks of moderate intensity aerobic exercise or usual care. Clinical assessment and measurement of serum NfL was done at baseline and after the intervention.Results: A total of 136 participants were included in the analysis. Groups were comparable at baseline except for APOE epsilon 4 carriership which was higher in the usual care group (75.3 versus 60.2%; p = 0.04). There was no effect of the intervention on serum NfL [intervention: baseline NfL (pg/mL) 25.76, change from baseline 0.87; usual care: baseline 27.09, change from baseline -1.16, p = 0.09].Conclusion: The findings do not support an effect of the exercise intervention on a single measure of neurodegeneration in AD. Further studies are needed using other types and durations of exercise and other measures of neurodegeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available