4.6 Review

Anti-inflammatory properties of commonly used psychiatric drugs

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Depression and inflammation: Correlation between changes in inflammatory markers with antidepressant response and long-term prognosis

Joakim Kofod et al.

Summary: The study found that inflammation may be associated with a specific subgroup of depression and differential antidepressant response, but not with overall depression severity. During treatment, some inflammatory markers decreased significantly, but these changes did not show clear correlations with different antidepressant responses, only showing small correlations with neurovegetative symptoms.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2022)

Article Neurosciences

Lithium inhibits tryptophan catabolism via the inflammation-induced kynurenine pathway in human microglia

Ria Goettert et al.

Summary: The study investigated the inhibitory effects of lithium on the inflammatory kynurenine pathway in microglia cells of the human brain, showing that lithium can reduce the activity of IDO1.
Article Behavioral Sciences

Challenges in the use of animal models and perspectives for a translational view of stress and psychopathologies

Nayara Cobra Barreiro Barroca et al.

Summary: The use of animal models in studying stress-related neuropsychiatric disorders is crucial, but there are limitations due to the complexity of these disorders. Animal models can only emulate specific features of human psychopathology and should be used cautiously. The effects of stress depend on various factors, such as duration, context, and individual variability. Animal models provide relevant evidence for understanding these disorders, as long as they meet certain criteria. However, there are challenges in translating the findings, such as reductionism and anthropomorphic interpretations.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2022)

Review Immunology

Anti-inflammatory medications for the treatment of mental disorders: A scoping review

Rebecca Fitton et al.

Summary: This scoping review assessed the effect of anti-inflammatory medications in mental disorders. The findings suggest that the use of anti-inflammatory agents in mental disorders may be beneficial, but treatment may differ depending on the specific disorder. Further studies with larger sample sizes are needed, considering inflammation markers.

BRAIN, BEHAVIOR, & IMMUNITY - HEALTH (2022)

Review Psychiatry

Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review

Velda X. Han et al.

Summary: Inflammation is linked to various common human problems and diseases, with maternal inflammatory states during pregnancy potentially impacting the pathogenesis of neurodevelopmental disorders in offspring. Further research is needed to explore the effects of maternal inflammation on NDD and disease mechanisms.

TRANSLATIONAL PSYCHIATRY (2021)

Article Clinical Neurology

The association between anti-inflammatory effects of long-term lithium treatment and illness course in Bipolar Disorder.

R. Queissner et al.

Summary: The study found a significant association between symptom progression, duration of lithium treatment, and hsCRP levels in male BD patients. Longer duration of lithium treatment was negatively correlated with hsCRP levels, suggesting a potential anti-inflammatory effect of lithium.

JOURNAL OF AFFECTIVE DISORDERS (2021)

Article Developmental Biology

Short communication: Ex-vivo effects of fluoxetine on production of biomarkers for inflammation and neurodevelopment by the placenta

Cara Clementelli et al.

Summary: Fluoxetine prescribed during pregnancy can lead to sex-specific behavioral changes in offspring, similar to infections. The drug has significant sex- and infection-dependent effects on BDNF production in placenta explant cultures. Further studies are needed to investigate these effects in vivo and their impact on pregnancy and neurodevelopment outcomes.

PLACENTA (2021)

Article Medicine, Research & Experimental

Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection

Justin Fortune Creeden et al.

Summary: The study suggests that the antidepressant fluoxetine may act as a potential therapy for hyperinflammatory states such as asthma, sepsis, and COVID-19 by targeting IL6ST and NF-kappaB Subunit 1 (NFKB1).

BIOMEDICINE & PHARMACOTHERAPY (2021)

Review Clinical Neurology

Maternal immune activation and neuroinflammation in human neurodevelopmental disorders

Velda X. Han et al.

Summary: Maternal inflammation during pregnancy can impact fetal neurodevelopment, increasing the risk of neurodevelopmental disorders in offspring. In addition to inflammation, epigenetic factors are also recognized to play a role in NDD pathogenesis.

NATURE REVIEWS NEUROLOGY (2021)

Article Psychiatry

Methylphenidate ameliorates the homeostatic balance between levels of kynurenines in ADHD children

Antonio Molina-Carballo et al.

Summary: The study found that the kynurenine pathway is involved in the efficacy of MPH treatment for ADHD, potentially exerting a protective effect by increasing plasma kynurenic acid and decreasing quinolinic acid excretion, with this impact being more pronounced in patients with depressive symptoms.

PSYCHIATRY RESEARCH (2021)

Review Chemistry, Multidisciplinary

Cytokines: From Clinical Significance to Quantification

Chao Liu et al.

Summary: Cytokines play a critical role in regulating immune and inflammatory responses, serving as biomarkers for many diseases. Quantification of cytokines provides valuable insights into physiological and pathological processes for diagnosis and treatment in both clinical medicine and biology. Advances in in vitro and in vivo assays, biosensors, and quantification platforms aim to achieve real-time multiplex cytokine analysis for biomedical research and clinical practice.

ADVANCED SCIENCE (2021)

Review Medicine, General & Internal

A Meta-Analysis of the Influence of Antipsychotics on Cytokines Levels in First Episode Psychosis

Piotr Marcinowicz et al.

Summary: The study shows that antipsychotic treatment leads to decreased concentrations of certain pro-inflammatory and anti-inflammatory cytokines in FEP patients, while leaving levels of other cytokines unaffected. Comparing with other meta-analyses involving schizophrenic subjects, the results are consistent in some cytokines but indicate a decrease in anti-inflammatory IL-10 in FEP patients after antipsychotic treatment.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

Clozapine: Why Is It So Uniquely Effective in the Treatment of a Range of Neuropsychiatric Disorders?

Dara Gammon et al.

Summary: Clozapine is superior in treating treatment-resistant schizophrenia and schizoaffective disorder, and is also used off-label for bipolar disorder, major depressive disorder, and Parkinson's disease. Electroconvulsive therapy has been used in conjunction with these psychiatric disorders, indicating common underlying mechanisms between the two treatments.

BIOMOLECULES (2021)

Article Pharmacology & Pharmacy

Ketamine attenuates high-glucose-mediated endothelial inflammation in human umbilical vein endothelial cells

Tianhai Wang et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

Inflammatory modulation of fluoxetine use in patients with depression: A systematic review and meta-analysis

Isabella Barros Almeida et al.

CYTOKINE (2020)

Article Biochemistry & Molecular Biology

Chronic inflammation in the etiology of disease across the life span

David Furman et al.

NATURE MEDICINE (2019)

Review Neurosciences

A brief history of antidepressant drug development: from tricyclics to beyond ketamine

Vitor Silva Pereira et al.

ACTA NEUROPSYCHIATRICA (2018)

Article Psychiatry

Neurodevelopmental disorders: prevalence and comorbidity in children referred to mental health services

Berit Hjelde Hansen et al.

NORDIC JOURNAL OF PSYCHIATRY (2018)

Review Neurosciences

A brief history of antidepressant drug development: from tricyclics to beyond ketamine

Vitor Silva Pereira et al.

ACTA NEUROPSYCHIATRICA (2018)

Review Neurosciences

The Role of the Immune System in Autism Spectrum Disorder

Amory Meltzer et al.

NEUROPSYCHOPHARMACOLOGY (2017)

Review Pharmacology & Pharmacy

Animal inflammation-based models of depression and their application to drug discovery

Li Ma et al.

EXPERT OPINION ON DRUG DISCOVERY (2017)

Article Psychiatry

The Link Between the Immune System, Environment, and Psychosis

Rajiv Radhakrishnan et al.

SCHIZOPHRENIA BULLETIN (2017)

Article Immunology

Rescue of IL-1β-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants

Alessandra Borsini et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

Review Clinical Neurology

The effect of mood-stabilizing drugs on cytokine levels in bipolar disorder: A systematic review

Seline van den Ameele et al.

JOURNAL OF AFFECTIVE DISORDERS (2016)

Review Clinical Neurology

Mood Stabilizers in Children and Adolescents With Autism Spectrum Disorders

Roberto Canitano

CLINICAL NEUROPHARMACOLOGY (2015)

Article Psychology, Clinical

The Economic Burden of Adults With Major Depressive Disorder in the United States (2005 and 2010)

Paul E. Greenberg et al.

JOURNAL OF CLINICAL PSYCHIATRY (2015)

Article Psychiatry

Does escitalopram reduce neurotoxicity in major depression?

Angelos Halaris et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2015)

Article Pharmacology & Pharmacy

Therapeutic effect of aripiprazole in chronic schizophrenia is accompanied by anti-inflammatory activity

Jaroslaw Sobis et al.

PHARMACOLOGICAL REPORTS (2015)

Review Medicine, General & Internal

Assessment and management of behavioral and psychological symptoms of dementia

Helen C. Kales et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

Review Medicine, General & Internal

Assessment and management of behavioral and psychological symptoms of dementia

Helen C. Kales et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

Article Clinical Neurology

Effects of Risperidone on Cytokine Profile in Drug-Naive First-Episode Psychosis

Cristiano Noto et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2015)

Article Biochemistry & Molecular Biology

Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis

A. Masi et al.

MOLECULAR PSYCHIATRY (2015)

Article Psychology, Developmental

Co-occurring Psychiatric Disorders in Preschool and Elementary School-Aged Children with Autism Spectrum Disorder

Fernando Salazar et al.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS (2015)

Article Psychology, Developmental

Brief Report: Forecasting the Economic Burden of Autism in 2015 and 2025 in the United States

J. Paul Leigh et al.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS (2015)

Review Immunology

Inflammation, ageing and chronic disease

Graham Pawelec et al.

CURRENT OPINION IN IMMUNOLOGY (2014)

Review Clinical Neurology

A review of the relationship between proinflammatory cytokines and major depressive disorder

Juan Joseph Young et al.

JOURNAL OF AFFECTIVE DISORDERS (2014)

Review Psychology, Developmental

Inflammation in Children and Adolescents With Neuropsychiatric Disorders: A Systematic Review

Rachel H. B. Mitchell et al.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2014)

Article Neurosciences

Cytokine Alterations in Bipolar Disorder: A Meta-Analysis of 30 Studies

Amirhossein Modabbernia et al.

BIOLOGICAL PSYCHIATRY (2013)

Article Immunology

Dysregulated relationship of inflammation and oxidative stress in major depression

B. J. Rawdin et al.

BRAIN BEHAVIOR AND IMMUNITY (2013)

Article Obstetrics & Gynecology

Opioids and clonidine modulate cytokine production and opioid receptor expression in neonatal immune cells

R. Chavez-Valdez et al.

JOURNAL OF PERINATOLOGY (2013)

Article Psychiatry

Impact of mood stabilizers and antiepileptic drugs on cytokine production in-vitro

Hubertus Himmerich et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2013)

Article Psychiatry

Antipsychotics' effects on blood levels of cytokines in schizophrenia: A meta-analysis

Valerie Tourjman et al.

SCHIZOPHRENIA RESEARCH (2013)

Review Pharmacology & Pharmacy

Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder

Chi-Tso Chiu et al.

PHARMACOLOGICAL REVIEWS (2013)

Article Psychiatry

Impact of antipsychotics on cytokine production in-vitro

Hubertus Himmerich et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2011)

Review Clinical Neurology

Cytokines mediated inflammation and decreased neurogenesis in animal models of depression

Cai Song et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2011)

Review Clinical Neurology

Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders

Ann Gardner et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2011)

Article Behavioral Sciences

Toward an anti-inflammatory strategy for depression

Shawn Hayley

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2011)

Article Psychiatry

Burden of psychiatric disorder in young adulthood and life outcomes at age 30

Sheree J. Gibb et al.

BRITISH JOURNAL OF PSYCHIATRY (2010)

Article Endocrinology & Metabolism

Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research

Xin Zhou et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2010)

Article Pharmacology & Pharmacy

Clozapine therapy raises serum concentrations of high sensitive C-reactive protein in schizophrenic patients

Stefan Loeffler et al.

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY (2010)

Review Clinical Neurology

Challenges and opportunities for drug discovery in psychiatric disorders: the drug hunters' perspective

Erik H. F. Wong et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2010)

Article Clinical Neurology

Cytokine levels in euthymic bipolar patients

Sinan Guloksuz et al.

JOURNAL OF AFFECTIVE DISORDERS (2010)

Article Psychology, Developmental

Lifetime Prevalence of Mental Disorders in U.S. Adolescents: Results from the National Comorbidity Survey Replication-Adolescent Supplement (NCS-A)

Kathleen Ries Merikangas et al.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2010)

Review Medicine, General & Internal

Serotonin, genetic variability, behaviour, and psychiatric disorders - a review

Niklas Nordquist et al.

UPSALA JOURNAL OF MEDICAL SCIENCES (2010)

Review Neurosciences

Bipolar disorder and mechanisms of action of mood stabilizers

Stanley I. Rapoport et al.

BRAIN RESEARCH REVIEWS (2009)

Review Clinical Neurology

Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or SNRI-refractory depression

Reiji Yoshimura et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2009)

Review Behavioral Sciences

Early-life programming of later-life brain and behavior: a critical role for the immune system

Staci D. Bilbo et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2009)

Article Clinical Neurology

Use of clonidine in children with autism spectrum disorders

Xue Ming et al.

BRAIN & DEVELOPMENT (2008)

Article Psychology, Developmental

Specificity of putative psychosocial risk factors for psychiatric disorders in children and adolescents

Lilly Shanahan et al.

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY (2008)

Editorial Material Medicine, Research & Experimental

Antipsychotics in the treatment of autism

David J. Posey et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Review Geriatrics & Gerontology

ELISA and multiplex technologies for cytokine measurement in inflammation and aging research

Sean X. Leng et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2008)

Review Clinical Neurology

Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder

Triin Eller et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2008)

Article Psychiatry

Treatment of inattention, overactivity, and impulsiveness in autism spectrum disorders

Michael G. Aman et al.

CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA (2008)

Article Oncology

Histone deacetylase inhibitors affect dendritic cell differentiation and immunogenicity

Alessio Nencioni et al.

CLINICAL CANCER RESEARCH (2007)

Article Clinical Neurology

Antidepressants suppress production of the Th1 cytokine interferon-γ, independent of monoamine transporter blockade

Michael Diamond et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2006)

Review Medicine, Research & Experimental

The role of ketamine in pain management

E. Visser et al.

BIOMEDICINE & PHARMACOTHERAPY (2006)

Review Neurosciences

Opinion - Gene-environment interactions in psychiatry: joining forces with neuroscience

Avshalom Caspi et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Review Medicine, General & Internal

Modern antipsychotic drugs: a critical overview

DM Gardner et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2005)

Article Clinical Neurology

Cytokine production in bipolar affective disorder patients under lithium treatment

F Boufidou et al.

JOURNAL OF AFFECTIVE DISORDERS (2004)

Review Clinical Neurology

Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review

M Vaswani et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2003)

Article Neurosciences

The effects of lithium on ex vivo cytokine production

MH Rapaport et al.

BIOLOGICAL PSYCHIATRY (2001)