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Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates
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NATURE REVIEWS NEUROSCIENCE (2011)
Transcription factor PITX3 gene in Parkinson's disease
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NEUROBIOLOGY OF AGING (2011)
Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease
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NEUROBIOLOGY OF AGING (2011)
Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
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NEUROBIOLOGY OF DISEASE (2011)
The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons
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BRAIN (2010)
Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain
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INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2010)
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 416insG mice
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MAMMALIAN GENOME (2010)
Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP
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NATURE NEUROSCIENCE (2010)
PITX3 polymorphism is associated with early onset Parkinson's disease
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NEUROBIOLOGY OF AGING (2010)
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TRENDS IN NEUROSCIENCES (2010)
Parkin protects dopaminergic neurons from excessive Wnt/β-catenin signaling
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Expression of the LIM-homeodomain gene Lmx1a in the postnatal mouse central nervous system
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BRAIN RESEARCH BULLETIN (2009)
A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death
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CELL (2009)
Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression
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DEVELOPMENT (2009)
Spontaneous Activity in the Developing Mouse Midbrain Driven by an External Pacemaker
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DEVELOPMENTAL NEUROBIOLOGY (2009)
Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson's disease?
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JOURNAL OF NEURAL TRANSMISSION (2009)
Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons
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JOURNAL OF NEUROCHEMISTRY (2009)
Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons
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JOURNAL OF NEUROSCIENCE (2009)
Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression
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NEURAL DEVELOPMENT (2009)
The transcription factor PITX3 is associated with sporadic Parkinson's disease
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NEUROBIOLOGY OF AGING (2009)
Haplotype Analysis of the Engrailed-2 Gene in Young-Onset Parkinson's Disease
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NEURODEGENERATIVE DISEASES (2009)
Characterisation of a novel NR4A2 mutation in Parkinson's disease brain
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NEUROSCIENCE LETTERS (2009)
Etiopathogenesis of Parkinson Disease: A New Beginning?
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NEUROSCIENTIST (2009)
Sonic Hedgehog Is a Chemoattractant for Midbrain Dopaminergic Axons
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PLOS ONE (2009)
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of α-synuclein
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AMERICAN JOURNAL OF HUMAN GENETICS (2008)
Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vityo and in vivo
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BRAIN RESEARCH (2008)
Calbindin 1, fibroblast growth factor 20, and α-synuclein in sporadic Parkinson's disease
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HUMAN GENETICS (2008)
A Nurr1 point mutant, implicated in Parkinson's disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription
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NEUROBIOLOGY OF DISEASE (2008)
Bone morphogenetic protein-7 reduces toxicity induced by high doses of methamphetamine in rodents
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NEUROSCIENCE (2008)
Characterization of the Engrailed mutant mice as experimental models for Parkinson's disease
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PARKINSONISM & RELATED DISORDERS (2008)
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TRENDS IN NEUROSCIENCES (2008)
The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age
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PLOS BIOLOGY (2007)
Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes
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NEUROSCIENCE (2007)
Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency
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DEVELOPMENT (2007)
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NATURE (2007)
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TRENDS IN NEUROSCIENCES (2007)
Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease
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TRENDS IN NEUROSCIENCES (2007)
Analysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed Parkinsonian nigra
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ACTA NEUROPATHOLOGICA (2007)
Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1
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JOURNAL OF NEUROSCIENCE (2007)
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NATURE NEUROSCIENCE (2007)
The gestational environment and Parkinson's disease: Evidence for neurodevelopmental origins of a neurodegenerative disorder
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REPRODUCTIVE TOXICOLOGY (2007)
Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A specific survival response in dopamine neurons at most risk in Parkinson's disease
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JOURNAL OF NEUROSCIENCE (2006)
Characterization of a mouse strain expressing Cre recombinase from the 3′ untranslated region of the dopamine transporter locus
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GENESIS (2006)
Translated mutation in the Nurr1 gene as a cause for Parkinson's disease
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MOVEMENT DISORDERS (2006)
Fibroblast growth factor receptor signaling affects development and function of dopamine neurons - inhibition results in a schizophrenia-like syndrome in transgenic mice
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JOURNAL OF NEUROCHEMISTRY (2006)
FGF-2 deficiency does not alter vulnerability of the dopaminergic nigrostriatal system towards MPTP intoxication in mice
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EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Transforming growth factor beta2 haploinsufficient mice develop age-related nigrostriatal dopamine deficits
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NEUROBIOLOGY OF DISEASE (2006)
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MOLECULAR AND CELLULAR NEUROSCIENCE (2006)
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JOURNAL OF COMPARATIVE NEUROLOGY (2006)
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CELL TRANSPLANTATION (2006)
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MOLECULAR BRAIN RESEARCH (2005)
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BRAIN RESEARCH BULLETIN (2005)
Bcl-x is required for proper development of the mouse substantia nigra
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JOURNAL OF NEUROSCIENCE (2005)
Sonic hedgehog delivered by an adeno-associated virus protects dopaminergic neurones against 6-OHDA toxicity in the rat
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JOURNAL OF NEURAL TRANSMISSION (2005)
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JOURNAL OF NEUROSCIENCE METHODS (2005)
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EXPERIMENTAL NEUROLOGY (2005)
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BRAIN RESEARCH (2004)
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CELL AND TISSUE RESEARCH (2004)
Differentiation and transcription factor gene therapy in experimental Parkinson's disease: Sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration
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MOLECULAR THERAPY (2004)
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BRAIN RESEARCH (2004)
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AMERICAN JOURNAL OF HUMAN GENETICS (2004)
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ANNALS OF NEUROLOGY (2003)
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JOURNAL OF NEUROSCIENCE RESEARCH (2003)
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ARCHIVES OF NEUROLOGY (2003)
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TRENDS IN MOLECULAR MEDICINE (2003)
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NATURE GENETICS (2003)
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JOURNAL OF COMPARATIVE NEUROLOGY (2002)
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NEURON (2002)
Expression patterns of fibroblast growth factors-18 and-20 in mouse embryos is suggestive of novel roles in calvarial and limb development
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MECHANISMS OF DEVELOPMENT (2002)
Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease
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EXPERIMENTAL NEUROLOGY (2002)
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NEUROSCIENCE (2002)
FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
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