Heterologous Omicron-adapted vaccine as a secondary booster promotes neutralizing antibodies against Omicron and its sub-lineages in mice

Letter Medicine, General & Internal

SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination

Rolando Pajon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Biochemistry & Molecular Biology

Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice

Baoling Ying et al.

Summary: The study showed that current vaccination can enhance protection against Omicron infections, but different vaccines have varying efficacy, which requires further investigation.

CELL (2022)

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Article Multidisciplinary Sciences

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant

Fanglei Zuo et al.

Summary: This study demonstrates that an mRNA vaccine booster in individuals vaccinated with inactivated vaccines can significantly increase the humoral and cellular immune responses against the virus, including the Omicron variant.

NATURE COMMUNICATIONS (2022)

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Review Biotechnology & Applied Microbiology

Research progress on vaccine efficacy against SARS-CoV-2 variants of concern

Lianlian Bian et al.

Summary: This review provides a brief overview of current variants of concern (VOCs), the protective efficacy of vaccines against VOCs, and the limitations in evaluating vaccine efficacy. Strategies for responding to variants are proposed for future epidemic prevention and control, as well as vaccine research and development.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2022)

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Article Public, Environmental & Occupational Health

Effectiveness of 2, 3, and 4 COVID-19 mRNA Vaccine Doses Among Immunocompetent Adults During Periods when SARS-CoV-2 Omicron BA.1 and BA.2/BA.2.12.1 Sublineages Predominated — VISION Network, 10 States, December 2021–June 2022

Ruth Link-Gelles et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2022)

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Article Immunology

Heterologous prime-boost: breaking the protective immune response bottleneck of COVID-19 vaccine candidates

Qian He et al.

Summary: Our study demonstrated that utilizing a heterologous prime-boost strategy with different combinations of COVID-19 vaccine candidates can enhance neutralizing antibody levels and T cell responses, providing new insights for vaccine development and application in controlling the SARS-CoV-2 pandemic.

EMERGING MICROBES & INFECTIONS (2021)

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Letter Public, Environmental & Occupational Health

Aerosol transmission of SARS-CoV-2: The unresolved paradox

Priyanka et al.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2020)

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Heterologous Omicron-adapted vaccine as a secondary booster promotes neutralizing antibodies against Omicron and its sub-lineages in mice

Related references

SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination

Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant

Research progress on vaccine efficacy against SARS-CoV-2 variants of concern

Effectiveness of 2, 3, and 4 COVID-19 mRNA Vaccine Doses Among Immunocompetent Adults During Periods when SARS-CoV-2 Omicron BA.1 and BA.2/BA.2.12.1 Sublineages Predominated — VISION Network, 10 States, December 2021–June 2022

Heterologous prime-boost: breaking the protective immune response bottleneck of COVID-19 vaccine candidates

Aerosol transmission of SARS-CoV-2: The unresolved paradox

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