Advances in the Clinical Application of Histamine and Diamine Oxidase (DAO) Activity: A Review

The serum level of diamine oxidase (DAO) reflects the integrity and maturation of the small intestinal mucosa. This measure is important in diagnosing various diseases, including chronic urticaria tachyphylaxis, multiple organ dysfunction syndrome, preterm abortion, and migraine. This review aimed to summarize the findings of previous studies on the changes in DAO levels in diverse diseases and the application of this enzyme in the clinical setting, as well as the roles of this enzyme under physiological and pathological conditions. The advances in the mechanism and clinical application of DAO presented in this review will contribute to a better understanding of this enzyme and open up new and broader perspectives for future basic research and clinical applications.

Automated summary

The serum level of diamine oxidase (DAO) is crucial in diagnosing various diseases and reflects the integrity and maturation of the small intestinal mucosa. This review summarizes previous studies on DAO level changes in diverse diseases, its clinical applications, and its roles under physiological and pathological conditions. The advances in understanding the mechanism and clinical applications of DAO presented in this review will contribute to future research and applications.