4.6 Review

Novel strategies to reverse chemoresistance in colorectal cancer

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

lncRNA-encoded pep-AP attenuates the pentose phosphate pathway and sensitizes colorectal cancer cells to Oxaliplatin

Xinyi Wang et al.

Summary: Oxaliplatin is a standard treatment for colorectal cancer, but chemoresistance is a challenge. A study found that a short peptide, pep-AP, can increase cancer cell sensitivity to L-OHP, offering a potential treatment option for L-OHP resistant CRC.

EMBO REPORTS (2022)

Article Biochemistry & Molecular Biology

Exosomal transfer of circ_0006174 contributes to the chemoresistance of doxorubicin in colorectal cancer by depending on the miR-1205/CCND2 axis

Yan Zhang et al.

Summary: The study revealed that circular RNA circ_0006174 plays a crucial role in doxorubicin chemoresistance in colorectal cancer, where it enhances chemoresistance by upregulating the miR-1205/CCND2 axis via exosomal transfer.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

Article Cell Biology

Engineered exosomes for co-delivery of PGM5-AS1 and oxaliplatin to reverse drug resistance in colon cancer

Bingqing Hui et al.

Summary: Oxaliplatin resistance is inevitable in almost all cases of metastatic colorectal cancer, making the study of lncRNAs and specific regulatory mechanisms crucial. Results show that PGM5-AS1 in colon cancer inhibits cell proliferation, migration, and oxaliplatin tolerance. Exosomes containing oxaliplatin and PGM5-AS1 can reverse drug resistance, while the mechanism of PGM5-AS1's regulation of target genes involves recruiting SRSF3 and affecting alternate splicing.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

Review Biochemistry & Molecular Biology

Smart Hydrogels for Advanced Drug Delivery Systems

Aydin Bordbar-Khiabani et al.

Summary: Smart hydrogels, a type of material that can respond to stimuli and adapt their responses based on external cues, have emerged as a promising research frontier in the field of biomedical engineering. With their high stability, physicochemical properties, and biocompatibility, smart hydrogels have the potential to be used in drug delivery systems. By changing their properties under external stimuli such as pH, temperature, electrical and magnetic fields, light, and biomolecules concentration, smart hydrogels can achieve controlled release of loaded drugs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop

Xiaomin Li et al.

Summary: circEXOC6B inhibits the progression of colorectal cancer (CRC) and enhances the chemosensitivity of CRC cells to 5-fluorouracil by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop. It may serve as a potential therapeutic target for CRC treatment.

MOLECULAR CANCER (2022)

Article Medicine, Research & Experimental

N6-methyladenosine-mediated LDHA induction potentiates chemoresistance of colorectal cancer cells through metabolic reprogramming

Kun Zhang et al.

Summary: The study reveals that the METTL3/LDHA axis-induced glucose metabolism could be a potential therapeutic target to overcome 5-FU resistance in CRC cells.

THERANOSTICS (2022)

Review Oncology

Engineered nanoparticles for imaging and drug delivery in colorectal cancer

Eluri Pavitra et al.

Summary: Colorectal cancer is one of the deadliest diseases worldwide due to a lack of early detection methods and appropriate drug delivery strategies. New screening tools and nanotechnology can improve accuracy and reduce harm to healthy tissues.

SEMINARS IN CANCER BIOLOGY (2021)

Review Integrative & Complementary Medicine

Combating Drug Resistance in Colorectal Cancer Using Herbal Medicines

Ga-Young Lee et al.

Summary: Colorectal cancer patients often experience treatment failure due to acquired drug resistance, and herbal medicines may serve as promising candidates to reverse this resistance, potentially developing into new adjuvant chemotherapy drugs.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2021)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of sphingosine-1-phosphate receptor 2 antagonists as potent 5-FU-resistance reversal agents for the treatment of colorectal cancer

Dongdong Luo et al.

Summary: 5-Fluorouracil (5-FU) and its prodrugs are essential clinical drugs for colorectal cancer (CRC) treatment, but drug resistance has led to high mortality rates among patients. Developing reversal agents for 5-FU resistance is urgently needed. A new compound 40 has shown promising potential in reversing 5-FU resistance in CRC treatment by inhibiting the expression of dihydropyrimidine dehydrogenase (DPD) and improving pharmacokinetic properties.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Circular RNA circCSPP1 knockdown attenuates doxorubicin resistance and suppresses tumor progression of colorectal cancer via miR-944/FZD7 axis

Lanlan Xi et al.

Summary: This research investigated the functional mechanism of circCSPP1 in colorectal cancer, revealing that circCSPP1 played a role in doxorubicin-resistant CRC by regulating the miR-944/FZD7 axis. Knockdown of circCSPP1 inhibited CRC cell growth and enhanced doxorubicin sensitivity. This suggests circCSPP1 as a potential target for CRC therapy.

CANCER CELL INTERNATIONAL (2021)

Article Immunology

miR-193a-5p as a promising therapeutic candidate in colorectal cancer by reducing 5-FU and Oxaliplatin chemoresistance by targeting CXCR4

Mohammad Reza Mohammad Hoseini Azar et al.

Summary: In this study, significantly downregulated miR-193a-5p and upregulated CXCR4 were observed in tumor tissues from CRC patients. Upregulation of miR-193a-5p reduced CXCR4 expression levels, particularly in combination with 5-FU and Ox. The findings suggest that miR-193a-5p may serve as a tumor-suppressive factor by targeting CXCR4 and could have potential implications in enhancing chemosensitivity in CRC.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Review Medicine, General & Internal

Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review

Leah H. Biller et al.

Summary: Colorectal cancer is the third most common cause of cancer mortality worldwide. For patients diagnosed with metastatic colorectal cancer, approximately 70% to 75% can survive beyond 1 year. Tailoring treatments based on the molecular and pathologic features of the tumor has shown to improve overall survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Medicine, Research & Experimental

Tumor-Associated Macrophages Promote Oxaliplatin Resistance via METTL3-Mediated m6A of TRAF5 and Necroptosis in Colorectal Cancer

Huanrong Lan et al.

Summary: The study found that infiltrated macrophage density in CRC tissues from OX-resistant patients was significantly higher, with increased m(6)A RNA content and METTL3 expression. M2-polarized TAMs enable OX resistance through elevated METTL3-mediated m(6)A modification in cells. Targeting M2-TAMs and METTL3-mediated m(6)A modification could be a promising adjuvant therapeutic strategy for CRC patients, especially for OX-resistant CRC patients.

MOLECULAR PHARMACEUTICS (2021)

Article Plant Sciences

Dihydromyricetin reverses MRP2-induced multidrug resistance by preventing NF-κB-Nrf2 signaling in colorectal cancer cell

Ziyuan Wang et al.

Summary: The study demonstrates that Dihydromyricetin (DMY) can restore chemosensitivity in colorectal cancer cells to oxaliplatin and vincristine by inhibiting MRP2 expression and its promoter activity. Additionally, DMY inhibits NF-kappa B/p65 expression, reducing its translocation to the nucleus and silencing Nrf2 signaling, resulting in decreased MRP2 expression. The combination of oxaliplatin and DMY shows a synergistic tumor suppression effect in vivo, suggesting NF-kappa B or Nrf2 as potential targets for CRC treatment.

PHYTOMEDICINE (2021)

Review Cell Biology

Exosome-Based Delivery of Natural Products in Cancer Therapy

Hang Song et al.

Summary: This review provides an overview of the application of exosomes as natural product delivery carriers in cancer therapy, focusing on their composition, biogenesis, and functions in cancer. The advantages and applications of exosomes in drug delivery for cancer therapy, as well as the recent progress and challenges in using exosomes as carriers for natural products in cancer treatment, are discussed in this review.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Chemistry, Multidisciplinary

Epigenetic Remodeling Hydrogel Patches for Multidrug-Resistant Triple-Negative Breast Cancer

Xiaoyuan Ji et al.

Summary: The hydrogel patch designed to modulate the plasticity of T-ICs in TNBC shows promising results in improving chemosensitivity, enhancing tumor immunogenicity, and increasing T-cell infiltration. Additionally, the patch efficiently suppresses tumor growth, postsurgical relapse, and metastasis with a single dose, demonstrating superior efficacy against multidrug resistance.

ADVANCED MATERIALS (2021)

Article Biochemistry & Molecular Biology

GW4064 enhances the chemosensitivity of colorectal cancer to oxaliplatin by inducing pyroptosis

Jing Guo et al.

Summary: Long-term oxaliplatin therapy may lead to drug resistance and severe adverse events, limiting its clinical use. A combination of GW4064 and oxaliplatin showed synergistic effects in colon cancer cells, inhibiting cell growth and inducing cell death to slow tumor growth.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Review Oncology

Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer

Shunhao Zhang et al.

Summary: Circular RNAs, a special type of noncoding RNA, exhibit high stability and potential gene regulation effects, playing roles in various biological functions and showing associations with the development and chemotherapy resistance of CRC.

CANCER MEDICINE (2021)

Article Oncology

Targeting EGFR sensitizes 5-Fu-resistant colon cancer cells through modification of the lncRNA-FGD5-AS1-miR-330-3p-Hexokinase 2 axis

Su-Jie Gao et al.

Summary: This study reveals the key roles of EGFR and lncRNA-FGD5-AS1 in 5-Fu resistance in CRC, promoting glycolysis through miR-330-3p-HK2 axis and leading to resistance to 5-Fu. Inhibiting EGFR effectively enhances the anti-tumor toxicity of 5-Fu.

MOLECULAR THERAPY-ONCOLYTICS (2021)

Article Biochemistry & Molecular Biology

Exosome-Mediated Transfer of circ_0000338 Enhances 5-Fluorouracil Resistance in Colorectal Cancer through Regulating MicroRNA 217 (miR-217) and miR-485-3p

Kui Zhao et al.

Summary: Exosomal circ_0000338 plays a role in promoting chemoresistance in colorectal cancer cells by interacting with miR-217 and miR-485-3p, affecting cell proliferation and apoptosis. Delivery of circ_0000338 via exosomes could serve as a potential diagnostic and therapeutic marker for 5-FU resistance in CRC patients.

MOLECULAR AND CELLULAR BIOLOGY (2021)

Article Multidisciplinary Sciences

Repositioning metformin and propranolol for colorectal and triple negative breast cancers treatment

L. E. Anselmino et al.

Summary: Drug repositioning accelerates drug development process, finding effective drugs with reduced side effects and lower costs. Combining metformin and propranolol shows potential as adjuvant therapy for both CRC and TNBC, as well as effective alternative for chemo-resistant CRC.

SCIENTIFIC REPORTS (2021)

Article Oncology

Downregulation of Circ_0071589 Suppresses Cisplatin Resistance in Colorectal Cancer by Regulating the MiR-526b-3p/KLFI2 Axis

Weitong Zhang et al.

Summary: This study revealed that circ_0071589 plays a role in regulating CDDP resistance in CRC by modulating the miR-526b-3p/KLF12 axis.

CANCER MANAGEMENT AND RESEARCH (2021)

Article Biochemistry & Molecular Biology

S-Adenosylmethionine Increases the Sensitivity of Human Colorectal Cancer Cells to 5-Fluorouracil by Inhibiting P-Glycoprotein Expression and NF-κB Activation

Laura Mosca et al.

Summary: S-Adenosylmethionine (AdoMet) enhances the antitumor activity of 5-Fluorouracil (5-FU) in colorectal cancer cells by inhibiting autophagy, reversing drug resistance-related protein expression, and decreasing the activation level of the antiapoptotic factor NF-kappa B.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, Research & Experimental

Overcoming multidrug resistance by knockout of ABCB1 gene using CRISPR/Cas9 system in SW620/Ad300 colorectal cancer cells

Zi-Ning Lei et al.

Summary: The CRISPR/Cas9 system successfully overcomes ABCB1-mediated multidrug resistance in colorectal cancer SW620/Ad300 cells. Knockout of the ABCB1 gene increases drug accumulation inside the cells and decreases drug efflux activity. Using 3D multicellular tumor spheroid model further proves that deficiency in ABCB1 inhibits tumor spheroid growth and restores sensitivity to drugs.

MEDCOMM (2021)

Article Oncology

Exosomal transfer of circular RNA FBXW7 ameliorates the chemoresistance to oxaliplatin in colorectal cancer by sponging miR-18b-5p

Yeqing Xu et al.

Summary: The study revealed that exosomal delivery of circ-FBXW7 can enhance oxaliplatin sensitivity, increase apoptosis induced by oxaliplatin, suppress epithelial-mesenchymal transition, and inhibit oxaliplatin efflux in colorectal cancer, offering a promising therapeutic strategy for oxaliplatin-resistant CRC patients.

NEOPLASMA (2021)

Review Genetics & Heredity

Application of CRISPR/Cas9 gene editing technique in the study of cancer treatment

Chunyang Jiang et al.

CLINICAL GENETICS (2020)

Article Biotechnology & Applied Microbiology

miR-200b-3p mitigates oxaliplatin resistance via targeting TUBB3 in colorectal cancer

Yu-Zhu Wu et al.

JOURNAL OF GENE MEDICINE (2020)

Article Materials Science, Biomaterials

A multi-functionalized nanocomposite constructed by gold nanorod core with triple-layer coating to combat multidrug resistant colorectal cancer

Yajun Jiang et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Biotechnology & Applied Microbiology

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

Gaofeng Liang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

Article Agriculture, Multidisciplinary

β-Sitosterol Reverses Multidrug Resistance via BCRP Suppression by Inhibiting the p53-MDM2 Interaction in Colorectal Cancer

Ziyuan Wang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

Article Pharmacology & Pharmacy

S1PR2 inhibitors potently reverse 5-FU resistance by downregulating DPD expression in colorectal cancer

Yu-Hang Zhang et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Biochemistry & Molecular Biology

The Interplay between Fe3O4 Superparamagnetic Nanoparticles, Sodium Butyrate, and Folic Acid for Intracellular Transport

Maria Teresa Cambria et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, Research & Experimental

The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer

Wu Sun et al.

THERANOSTICS (2020)

Review Cell Biology

Regulation of microRNA function in animals

Luca F. R. Gebert et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Oncology

Treatment sequencing in metastatic colorectal cancer

D. P. Modest et al.

EUROPEAN JOURNAL OF CANCER (2019)

Article Cell Biology

TIAM1 promotes chemoresistance and tumor invasiveness in colorectal cancer

Daisuke Izumi et al.

CELL DEATH & DISEASE (2019)

Article Biochemistry & Molecular Biology

Nonsteroidal Anti-Inflammatory Drugs Prevent Vincristine-Dependent Cancer-Associated Fibroblasts Formation

Marta Ewelina Wawro et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Ladan Mashouri et al.

MOLECULAR CANCER (2019)

Article Oncology

Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-B pathway

Lu Jiang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Review Pharmacology & Pharmacy

Drugs Targeting Epigenetic Modifications and Plausible Therapeutic Strategies Against Colorectal Cancer

Srinivas Patnaik et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Nanoscience & Nanotechnology

Carrier-Free Supramolecular Hydrogel Composed of Dual Drugs for Conquering Drug Resistance

Chunhua Ren et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Review Endocrinology & Metabolism

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Marc Foretz et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

Review Medicine, General & Internal

Colorectal cancer

Evelien Dekker et al.

LANCET (2019)

Article Biotechnology & Applied Microbiology

Tanshinone IIA Reverses Oxaliplatin Resistance In Human Colorectal Cancer Via Inhibition Of ERK/Akt Signaling Pathway

Yonggang Zhang et al.

ONCOTARGETS AND THERAPY (2019)

Article Pathology

Evaluation of cisplatin-hydrogel for improving localized antitumor efficacy in gastric cancer

Keyang Qian et al.

PATHOLOGY RESEARCH AND PRACTICE (2019)

Article Cell Biology

Downregulation of lncRNA CCAT1 enhances 5-fluorouracil sensitivity in human colon cancer cells

Chun Yang et al.

BMC MOLECULAR AND CELL BIOLOGY (2019)

Article Materials Science, Biomaterials

Enhanced local cancer therapy using a CA4P and CDDP co-loaded polypeptide gel depot

Shuangjiang Yu et al.

BIOMATERIALS SCIENCE (2019)

Article Biochemistry & Molecular Biology

Knockdown of ADAM17 inhibits cell proliferation and increases oxaliplatin sensitivity in HCT-8 colorectal cancer through EGFR-PI3K-AKT activation

Qi Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Medicine, Research & Experimental

GDPD5, a target of miR-195-5p, is associated with metastasis and chemoresistance in colorectal cancer

Chun Feng et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Biochemistry & Molecular Biology

Overcoming sternness and chemoresistance in colorectal cancer through miR-195-5p-modulated inhibition of notch signaling

Yinghu Jin et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Article Biochemistry & Molecular Biology

Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells HCT116

Egle Kukcinaviciute et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Article Nanoscience & Nanotechnology

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

Myung Soo Kim et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

Review Oncology

Sphingolipid metabolism in cancer signalling and therapy

Besim Ogretmen

NATURE REVIEWS CANCER (2018)

Article Biochemistry & Molecular Biology

Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU

Y. X. Fan et al.

GENETICS AND MOLECULAR RESEARCH (2017)

Article Biochemistry & Molecular Biology

miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1

Yanqing Liu et al.

MOLECULAR CANCER (2017)

Article Pharmacology & Pharmacy

Identification of Predictive DNA Methylation Biomarkers for Chemotherapy Response in Colorectal Cancer

Rashidah Baharudin et al.

FRONTIERS IN PHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism

Shengchao Lin et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Evodiamine Suppresses ABCG2 Mediated Drug Resistance by Inhibiting p50/p65 NF-κB Pathway in Colorectal Cancer

Hua Sui et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2016)

Article Biotechnology & Applied Microbiology

Combination Therapy of Lactobacillus plantarum Supernatant and 5-Fluouracil Increases Chemosensitivity in Colorectal Cancer Cells

JaeJin An et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2016)

Article Nanoscience & Nanotechnology

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Myung Soo Kim et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

Article Medicine, Research & Experimental

Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines

Karolina Wojtowicz et al.

BIOMEDICINE & PHARMACOTHERAPY (2015)

Article Multidisciplinary Sciences

Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance

Joao Conde et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

Overcoming Cancer Multidrug Resistance by Codelivery of Doxorubicin and Verapamil with Hydrogel Nanoparticles

Ming Qin et al.

MACROMOLECULAR BIOSCIENCE (2014)

Article Biochemistry & Molecular Biology

Protein Kinase Cα Protects Against Multidrug Resistance in Human Colon Cancer Cells

Se-Kyoung Lee et al.

MOLECULES AND CELLS (2012)

Article Medical Laboratory Technology

Livin gene plays a role in drug resistance of colon cancer cells

Xudong Wang et al.

CLINICAL BIOCHEMISTRY (2010)

Article Medicine, General & Internal

Colorectal cancer

David Cunningham et al.

LANCET (2010)

Review Medicine, General & Internal

Drug therapy: EGFR antagonists in cancer treatment

Fortunato Ciardiello et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Gastroenterology & Hepatology

Tamoxifen can reverse multidrug resistance of colorectal carcinoma in vivo

Li-Zong Shen et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2005)

Review Oncology

Molecular mechanisms of drug resistance

DB Longley et al.

JOURNAL OF PATHOLOGY (2005)

Article Biochemistry & Molecular Biology

Antisense oligonucleotide-based therapeutics for cancer

NM Dean et al.

ONCOGENE (2003)

Review Immunology

Exosomes:: Composition, biogenesis and function

C Théry et al.

NATURE REVIEWS IMMUNOLOGY (2002)

Article Biochemistry & Molecular Biology

Reversal of cisplatin and multidrug resistance by ribozyme-mediated glutathione suppression

J Nagata et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)