4.6 Article

Circulating gamma-glutamyl transpeptidase and risk of pancreatic cancer: A prospective cohort study in the UK Biobank

Journal

CANCER MEDICINE
Volume 12, Issue 7, Pages 7877-7887

Publisher

WILEY
DOI: 10.1002/cam4.5556

Keywords

European ancestry; gamma-glutamyl transpeptidase; pancreatic cancer; prevention

Categories

Ask authors/readers for more resources

The study found a positive association between serum gamma-glutamyl transpeptidase (GGT) level and pancreatic cancer risk. Each one standard deviation increase in GGT level was associated with a 14% higher risk of pancreatic cancer. The highest GGT group had a 1.68-fold increased risk compared to the lowest GGT group, and this association was observed in both men (GGT≥50.2 U/L) and women (GGT≥31.6 U/L).
BackgroundTo determine whether serum gamma-glutamyl transpeptidase (GGT) level is associated with pancreatic cancer risk in a large prospective cohort.MethodsThe study analyzed serum GGT concentration at baseline of 421,032 participants recruited in the UK Biobank since 2006 through 2010. Information on incidence of pancreatic cancer was obtained from cancer and death registers, updated until 2015 in Scotland or 2016 in England and Wales. Adjusted Cox proportional hazards models were used to measure the association between serum GGT and pancreatic cancer risk.ResultsThe study identified 586 cases of pancreatic cancer over a median follow-up period of 7.16 years. In the multivariable-adjusted Cox model, serum GGT level was associated with 14% higher pancreatic cancer risk (hazard ratio (HR) per one standard deviation increment of log2 GGT level = 1.14, 95% confidence interval (CI) 1.02-1.28, p = 0.025). In the total population, the HR for the highest GGT group was 1.68 (95%CI: 1.22-2.30) versus the lowest GGT group. The HR for the highest GGT group in men (& GE;50.2 U/L) was 1.72 (95%CI: 1.14-2.61) and that in women (& GE;31.6 U/L) was 1.75 (95%CI: 1.06-2.88) versus the lowest GGT group.ConclusionOur findings suggested a positive association of serum GGT in pancreatic cancer etiology, implying the potential of monitoring GGT level for identifying at-risk individuals for pancreatic cancer.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available