Journal
BIOLOGY OPEN
Volume 11, Issue 11, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/bio.059525
Keywords
Drosophila; Cell competition; Epithelial polarity; Scrib; Dlg; PTP10D
Categories
Funding
- National Institutes of Health [GM130388]
- Independent Research Fund Denmark fellowship [0131-00010B]
- University of California Berkeley
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A study suggests that the receptor tyrosine phosphatase PTP10D may not be necessary for the elimination of polarity-deficient mutant cells in developing Drosophila imaginal discs.
Animal organs maintain tissue integrity and ensure removal of aberrant cells through several types of surveillance mechanisms. One prominent example is the elimination of polarity-deficient mutant cells within developing Drosophila imaginal discs. This has been proposed to require heterotypic cell competition dependent on the receptor tyrosine phosphatase PTP10D within the mutant cells. We report here experiments to test this requirement in various contexts and find that PTP10D is not obligately required for the removal of scribble (scrib) mutant and similar polarity-deficient cells. Our experiments used identical stocks with which another group can detect the PTP10D requirement, and our results do not vary under several husbandry conditions including high and low protein food diets. Although we are unable to identify the source of the discrepant results, we suggest that the role of PTP10D in polarity-deficient cell elimination may not be absolute.
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