Journal
ACTA CLINICA BELGICA
Volume 78, Issue 4, Pages 336-341Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17843286.2022.2156701
Keywords
Statin; 3-hydroxy-3-methylglutaryl-coenzyme a reductase; SINAM; myopathy
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Statins are effective in treating hypercholesterolemia, but can sometimes cause muscle-related side effects. Recently, there have been reports of statin-induced necrotizing autoimmune myopathy (SINAM) which can be life-threatening. We present a case of a female patient who experienced persistent symptoms after discontinuing statin therapy and was diagnosed with SINAM, leading to treatment with immunosuppressants.
Statins are a well-known and highly effective treatment for hypercholesterolemia in order to prevent cardiovascular disease. Occasionally, patients may experience muscle-related events such as myalgia or muscle cramps. Recently, SINAM (statin-induced necrotizing autoimmune myopathy) has been described in patients using statins. Although very uncommon, it may cause a life-threatening situation associated with rhabdomyolysis. We present a case concerning a 71-year-old woman who presented with muscle fatigue for several weeks. Statin therapy was discontinued but symptoms did not resolve. Further workup led to a diagnosis of SINAM for which treatment with immunosuppressants was started.
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