4.7 Article

Association of circadian rhythms with brain disorder incidents: a prospective cohort study of 72242 participants

Journal

TRANSLATIONAL PSYCHIATRY
Volume 12, Issue 1, Pages -

Publisher

SPRINGERNATURE
DOI: 10.1038/s41398-022-02278-1

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Funding

  1. Science and Technology Innovation Major Projects [2022ZD0211600]
  2. National Natural Science Foundation of China [82071201, 81971032, 82071997]
  3. Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
  4. Research Start-up Fund of Huashan Hospital [2022QD002]
  5. Excellence 2025 Talent Cultivation Program at Fudan University [3030277001]
  6. Shanghai Talent Development [2019074]
  7. Shanghai Rising-Star Program [21QA1408700]
  8. 111 Project [B18015]
  9. ZHANGJIANG LAB, Tianqiao and Chrissy Chen Institute
  10. State Key Laboratory of Neurobiology and Frontiers Center for Brain Science of Ministry of Education
  11. Shanghai Center for Brain science and Brain-Inspired Technology, Fudan University

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Circadian rhythm disruption is a risk factor for various brain disorders, and individuals with reduced relative amplitude have an increased risk of developing dementia, Parkinson's disease, stroke, major depression disorder, and anxiety disorder. Significant correlations were found between relative amplitude and several brain regions and white matter tracts linked to dementia and psychiatric disorders.
Circadian rhythm disruption (CRD) is a shared characteristic of various brain disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), and major depression disorder (MDD). Disruption of circadian rhythm might be a risk factor for brain disorder incidents. From 7-day accelerometry data of 72,242 participants in UK Biobank, we derived a circadian relative amplitude variable, which to some extent reflected the degree of circadian rhythm disruption. Records of brain disorder incidents were obtained from a wide range of health outcomes across self-report, primary care, hospital inpatient data, and death data. Using multivariate Cox proportional hazard ratio regression, we created two models adjusting for different covariates. Then, linear correlations between relative amplitude and several brain morphometric measures were examined in participants with brain MRI data. After a median follow-up of around 6.1 years, 72,242 participants were included in the current study (female 54.9%; mean age 62.1 years). Individuals with reduced relative amplitude had increasing risk of all-cause dementia (Hazard ratio 1.23 [95% CI 1.15 to 1.31]), PD (1.33 [1.25 to 1.41]), stroke (1.13 [1.06 to 1.22]), MDD (1.18 [1.13 to 1.23]), and anxiety disorder (1.14 [1.09 to 1.20]) in fully adjusted models. Additionally, significant correlations were found between several cortical regions and white matter tracts and relative amplitude that have been linked to dementia and psychiatric disorders. We confirm CRD to be a risk factor for various brain disorders. Interventions for regulating circadian rhythm may have clinical relevance to reducing the risk of various brain disorders.

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