4.7 Article

Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain

Related references

Note: Only part of the references are listed.
Article Medicine, General & Internal

Donanemab in Early Alzheimer's Disease

Mark A. Mintun et al.

Summary: In this study, donanemab showed improved composite scores for cognition and daily living activities compared to placebo in patients with early Alzheimer's disease at 76 weeks, although secondary outcomes varied. Longer and larger trials are needed to further explore the efficacy and safety of donanemab in Alzheimer's disease.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Editorial Material Multidisciplinary Sciences

Treatments for Alzheimer's disease emerge

Dennis J. Selkoe

SCIENCE (2021)

Article Clinical Neurology

A beta oligomers trigger and accelerate A beta seeding

Natalie Katzmarski et al.

BRAIN PATHOLOGY (2020)

Article Clinical Neurology

The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer's disease

Baayla D. C. Boon et al.

ACTA NEUROPATHOLOGICA (2020)

Review Clinical Neurology

A critical appraisal of amyloid-βtargeting therapies for Alzheimer disease

Francesco Panza et al.

NATURE REVIEWS NEUROLOGY (2019)

Article Multidisciplinary Sciences

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β

Joseph W. Arndt et al.

SCIENTIFIC REPORTS (2018)

Article Chemistry, Medicinal

Inhibition of β-Amyloid Channels with a Drug Candidate wgx-50 Revealed by Molecular Dynamics Simulations

Shuang Hou et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)

Article Multidisciplinary Sciences

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

Y. Anraku et al.

NATURE COMMUNICATIONS (2017)

Review Neurosciences

Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges

Holger Cynis et al.

MOLECULAR NEURODEGENERATION (2016)

Article Clinical Neurology

Bapineuzumab for mild to moderate Alzheimer's disease in two global, randomized, phase 3 trials

Rik Vandenberghe et al.

ALZHEIMERS RESEARCH & THERAPY (2016)

Article Neurosciences

A Novel Drug Candidate for Alzheimer's Disease Treatment: gx-50 Derived from Zanthoxylum Bungeanum

Maoping Tang et al.

JOURNAL OF ALZHEIMERS DISEASE (2013)

Article Biotechnology & Applied Microbiology

Disease Modifying Therapies for Alzheimer's Disease Targeting Aβ Oligomers: Implications for Therapeutic Mechanisms

Etsuro Matsubara et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Review Neurosciences

Structure and function of the blood-brain barrier

N. Joan Abbott et al.

NEUROBIOLOGY OF DISEASE (2010)

Article Chemistry, Multidisciplinary

Charge-Conversional Polyionic Complex Micelles-Efficient Nanocarriers for Protein Delivery into Cytoplasm

Yan Lee et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Article Clinical Neurology

A new amyloid μ variant favoring oligomerization in Alzheimer's-type dementia

Takami Tomiyama et al.

ANNALS OF NEUROLOGY (2008)

Article Biochemistry & Molecular Biology

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease-like pathology

Stephan Schilling et al.

NATURE MEDICINE (2008)

Article Biochemistry & Molecular Biology

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Ganesh M. Shankar et al.

NATURE MEDICINE (2008)

Article Biochemistry & Molecular Biology

On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)

Stephan Schilling et al.

BIOCHEMISTRY (2006)

Review Pharmacology & Pharmacy

Metabolism of amyloid-β peptide and Alzheimer's disease

N Iwata et al.

PHARMACOLOGY & THERAPEUTICS (2005)

Article Chemistry, Multidisciplinary

Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression

K Miyata et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

Article Multidisciplinary Sciences

Alzheimer's disease is a synaptic failure

DJ Selkoe

SCIENCE (2002)