4.4 Article

Anthelmintic resistance in equine nematodes: Current status and emerging trends

Related references

Note: Only part of the references are listed.
Article Parasitology

World association for the advancement of veterinary parasitology (WAAVP): Third edition of guideline for evaluating the efficacy of equine anthelmintics

Martin K. Nielsen et al.

Summary: This document provides guidelines for the design, execution, and interpretation of studies evaluating the efficacy of anthelmintic drugs against internal parasites in equines. It outlines the design and execution of critical and controlled studies, discussing their advantages and disadvantages. The document includes specific considerations for different target parasites, as well as information on animal selection, randomization procedures, housing, feeding, dosage titration, and field studies. It also provides guidance on group size determination and statistical analysis of study results. The aim of this guideline is to assist investigators in evaluating anthelmintic drugs in horses using comparable and standardized procedures with appropriate sample sizes.

VETERINARY PARASITOLOGY (2022)

Article Veterinary Sciences

Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations

Jana Napravnikova et al.

Summary: The control of strongylid infections in horses has become challenging due to anthelmintic resistance. This study in the Czech Republic evaluated the efficacy of different anthelmintics and found total failure of fenbendazole and reduced efficacy of pyrantel embonate. Ivermectin and moxidectin exhibited excellent efficacy. The findings highlight the need for advanced parasite control approaches to slow the spread of anthelmintic resistance.

FRONTIERS IN VETERINARY SCIENCE (2022)

Article Parasitology

Equine strongylids: Ivermectin efficacy and fecal egg shedding patterns

Martin K. Nielsen et al.

Summary: This study aimed to evaluate the efficacy of ivermectin in controlling equine cyathostomins, a parasitic worm commonly found in grazing horses. The study found evidence of ivermectin resistance in one group of yearlings, while the remaining groups showed no resistance. The study also analyzed the factors influencing strongylid egg shedding levels in mares.

PARASITOLOGY RESEARCH (2022)

Article Agriculture, Dairy & Animal Science

Reduction of the nematode egg reappearance period in horses after anthelmintic therapy

Maria V. Baranova et al.

Summary: The study revealed high rates of nematode infection in horses in the Moscow Region, with Parascaris equorum being the most common. The egg reappearance period indicated the need for additional monitoring of anthelmintic resistance for effective control.

VETERINARY WORLD (2022)

Article Parasitology

Shortened egg reappearance periods of equine cyathostomins following ivermectin or moxidectin treatment: morphological and molecular investigation of efficacy and species composition

Martin K. Nielsen et al.

Summary: This study investigated the efficacy of moxidectin and ivermectin against equine parasites and the egg reappearance period, revealing different efficacies of the two drugs against adult and larval stages at different time points. Additionally, differential activity of moxidectin and ivermectin on certain cyathostomin species was observed.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2022)

Article Parasitology

Shortened egg reappearance periods of equine cyathostomins following ivermectin or moxidectin treatment: morphological and molecular investigation of efficacy and species composition

Martin K. Nielsen et al.

Summary: This study provides a comprehensive investigation of current macrocyclic lactone efficacy patterns and important insight into potential mechanisms behind shortened egg reappearance periods.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2022)

Article Veterinary Sciences

Monitoring equine ascarid and cyathostomin parasites: Evaluating health parameters under different treatment regimens

Martin K. Nielsen et al.

Summary: This study found that reducing the intensity of anthelmintic treatment for foals and mares in equine stud farms did not have significant negative health consequences, despite higher parasite egg counts in some foal groups.

EQUINE VETERINARY JOURNAL (2021)

Article Parasitology

FIRST REPORT OF RESISTANCE TO IVERMECTIN IN PARASCARIS UNIVALENS IN ICELAND

Frida Martin et al.

Summary: The study found that Icelandic horses have developed resistance to ivermectin against Parascaris univalens infection, highlighting the need to consider alternative drugs for treatment.

JOURNAL OF PARASITOLOGY (2021)

Article Parasitology

Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses

Ghazanfar Abbas et al.

Summary: This study provides evidence of MOX- and multidrug-resistant (ABM and combinations of anthelmintics) cyathostomins in Australia, emphasizing the need for continuous surveillance of the efficacy of currently effective anthelmintics and large-scale investigations to assess the egg reappearance period for various anthelmintics.

PARASITES & VECTORS (2021)

Article Parasitology

Exploring the β-tubulin gene family in a benzimidazole-resistant Parascaris univalens population

Frida Martin et al.

Summary: The study investigated benzimidazole resistance in Parascaris univalens, identifying new 13-tubulin genes and revealing their phylogenetic relationships, while confirming the presence of a resistant population in a Swedish stud farm. Despite no SNPs found to distinguish resistant and susceptible populations, the research underscores the ongoing need for molecular markers for benzimidazole resistance in P. univalens.

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2021)

Article Veterinary Sciences

Anthelmintic resistance in Creole horses in the South of Rio Grande do Sul, Brazil

J. S. Lignon et al.

Summary: The objective of the study was to evaluate antiparasitic resistance against horse nematodes in the South of Rio Grande do Sul, Brazil. Despite isolated success with Ivermectin, results indicate widespread resistance to macrocyclic lactones in equine parasites in this region.

ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA (2021)

Article Veterinary Sciences

Reduced Efficacy of Fenbendazole and Pyrantel Pamoate Treatments against Intestinal Nematodes of Stud and Performance Horses

Stefania Zanet et al.

Summary: Changes in the parasitic fauna of horses have led to cyathostomins becoming the major parasites in adult horses, while large strongyles have decreased in prevalence. Parascaris spp. remains the most important parasite in foals and weanlings. Anthelmintic resistance is prevalent worldwide in cyathostomins and Parascaris spp., impacting treatment decisions. Testing in Northern Italy found high rates of strongyle-type eggs in horses and lower rates of Parascaris spp., with reduced efficacy of fenbendazole and pyrantel pamoate against cyathostomins. Ground-based actions are needed to prevent clinical disease and reduce selection pressure of resistant parasites.

VETERINARY SCIENCES (2021)

Article Veterinary Sciences

Anthelmintic resistance of horse strongyle nematodes to ivermectin and pyrantel in Lithuania

Evelina Dauparaite et al.

Summary: The study revealed prevalent PYR resistance on horse farms in Lithuania, while the efficacy of IVM seems unaffected. These findings should lead to the implementation of more sustainable management of strongyle infections in horses in Lithuania.

ACTA VETERINARIA SCANDINAVICA (2021)

Article Parasitology

Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm

M. K. Nielsen et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2020)

Article Veterinary Sciences

A survey of ivermectin resistance in Parascaris species infected foals in south-eastern Poland

Maria Bernadeta Studzinska et al.

ACTA VETERINARIA SCANDINAVICA (2020)

Article Parasitology

The importance of anthelmintic efficacy monitoring: results of an outreach effort

Jennifer L. Cain et al.

PARASITOLOGY RESEARCH (2019)

Article Parasitology

Anthelmintic therapy of equine cyathostomin nematodes - larvicidal efficacy, egg reappearance period, and drug resistance

Jennifer L. Bellaw et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2018)

Article Parasitology

Anthelmintic efficacy against equine strongyles in the United States

M. K. Nielsen et al.

VETERINARY PARASITOLOGY (2018)

Article Parasitology

Parasite control strategies used by equine owners in the United States: A national survey

M. K. Nielsen et al.

VETERINARY PARASITOLOGY (2018)

Article Veterinary Sciences

Effects of Ivermectin and Moxidectin on Fecal Egg Count and Egg Reappearance Rate in Horses

Cheryl A. Shea Porr et al.

JOURNAL OF EQUINE VETERINARY SCIENCE (2017)

Article Biotechnology & Applied Microbiology

Anthelmintic Resistance of Strongyle Nematodes to Ivermectin and Fenbendazole on Cart Horses in Gondar, Northwest Ethiopia

Zewdu Seyoum et al.

BIOMED RESEARCH INTERNATIONAL (2017)

Article Parasitology

Risk factor analysis of equine strongyle resistance to anthelmintics

G. Salle et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2017)

Article Veterinary Sciences

Searching for ivermectin resistance in a Strongylidae population of horses stabled in Poland

A. Zak et al.

BMC VETERINARY RESEARCH (2017)

Article Veterinary Sciences

Efficacy of a morantel-abamectin combination for the treatment of resistant ascarids in foals

E. J. A. Wilkes et al.

AUSTRALIAN VETERINARY JOURNAL (2017)

Article Veterinary Sciences

Shortened egg reappearance after ivermectin or moxidectin use in horses in the UK

S. P. Daniels et al.

VETERINARY JOURNAL (2016)

Article Parasitology

Dynamics of Parascaris and Strongylus spp. parasites in untreated juvenile horses

J. V. Fabiani et al.

VETERINARY PARASITOLOGY (2016)

Article Parasitology

Benzimidazole resistance in equine cyathostomins in India

Sunil Kumar et al.

VETERINARY PARASITOLOGY (2016)

Article Parasitology

Ivermectin failure in the control of Oxyuris equi in a herd of ponies in France

Guillaume Salle et al.

VETERINARY PARASITOLOGY (2016)

Article Veterinary Sciences

Suspected ivermectin resistance in a south-east Queensland Parascaris equorum population

A. Beasley et al.

AUSTRALIAN VETERINARY JOURNAL (2015)

Article Parasitology

Susceptibility of helminth species from horses against different chemical compounds in Brazil

Gustavo Felippelli et al.

VETERINARY PARASITOLOGY (2015)

Article Veterinary Sciences

An investigation of anthelmintic efficacy against strongyles on equine yards in Scotland

C. H. Stratford et al.

EQUINE VETERINARY JOURNAL (2014)

Article Veterinary Sciences

A questionnaire study of equine gastrointestinal parasite control in Scotland

C. H. Stratford et al.

EQUINE VETERINARY JOURNAL (2014)

Article Parasitology

Anthelmintic efficacy on UK Thoroughbred stud farms

Valerie E. Relf et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2014)

Article Parasitology

Parascaris univalens-a victim of large-scale misidentification?

Martin K. Nielsen et al.

PARASITOLOGY RESEARCH (2014)

Review Parasitology

Anthelmintic resistance in important parasites of horses: Does it really matter?

Andrew S. Peregrine et al.

VETERINARY PARASITOLOGY (2014)

Article Parasitology

Arrested development of experimental Cyathostominae infections in ponies in Czech republic

Stepanka Schankova et al.

VETERINARY PARASITOLOGY (2014)

Article Parasitology

Oxyuris equi: Lack of efficacy in treatment with macrocyclic lactones

Denis Wolf et al.

VETERINARY PARASITOLOGY (2014)

Review Parasitology

Anthelmintic resistance in equine nematodes

Jacqueline B. Matthews

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2014)

Article Veterinary Sciences

Determination of anthelmintic efficacy against equine cyathostomins and Parascaris equorum in France

T. Geurden et al.

EQUINE VETERINARY EDUCATION (2013)

Article Veterinary Sciences

Equine Cyathostomin Resistance to Fenbendazole in Texas Horse Facilities

Arlene Garcia et al.

JOURNAL OF EQUINE VETERINARY SCIENCE (2013)

Article Parasitology

Hierarchical model for evaluating pyrantel efficacy against strongyle parasites in horses

M. K. Nielsen et al.

VETERINARY PARASITOLOGY (2013)

Article Parasitology

Anthelmintic efficacy against cyathostomins in horses in Southern England

H. E. Lester et al.

VETERINARY PARASITOLOGY (2013)

Article Parasitology

Lack of Cyathostomin sp reduction after anthelmintic treatment in horses in Brazil

Ricardo J. Canever et al.

VETERINARY PARASITOLOGY (2013)

Article Veterinary Sciences

Preliminary Analysis of the Results of Selective Therapy Against Strongyles in Pasturing Horses

Ruben Francisco et al.

JOURNAL OF EQUINE VETERINARY SCIENCE (2012)

Article Parasitology

Comparative performance of macrocyclic lactones against large strongyles in horses

G. Toscan et al.

PARASITOLOGY INTERNATIONAL (2012)

Article Parasitology

Efficacy of major anthelmintics against horse cyathostomins in France

Donato Traversa et al.

VETERINARY PARASITOLOGY (2012)

Article Parasitology

Anthelmintic resistance in non-strongylid parasites of horses

Craig R. Reinemeyer

VETERINARY PARASITOLOGY (2012)

Review Parasitology

Anthelmintic resistance in nematode parasites of cattle: a global issue?

Ian A. Sutherland et al.

TRENDS IN PARASITOLOGY (2011)

Article Veterinary Sciences

Fecal egg counts after anthelmintic administration to aged horses and horses with pituitary pars intermedia dysfunction

Dianne McFarlane et al.

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2010)

Article Parasitology

Are macrocyclic lactones useful drugs for the treatment of Parascaris equorum infections in foals?

Fabrizia Veronesi et al.

VETERINARY PARASITOLOGY (2010)

Article Multidisciplinary Sciences

Identifying sub-optimal responses to ivermectin in the treatment of River Blindness

Thomas S. Churcher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Veterinary Sciences

Anthelmintic efficacy on Parascaris equorum in foals on Swedish studs

Eva Osterman Lind et al.

ACTA VETERINARIA SCANDINAVICA (2009)

Article Veterinary Sciences

Anthelmintic resistant nematodes in Brazilian horses

M. B. Molento et al.

VETERINARY RECORD (2008)

Article Veterinary Sciences

Occurrence of anthelmintic resistant equine cyathostome populations in central and southern Italy

Donato Traversa et al.

PREVENTIVE VETERINARY MEDICINE (2007)

Article Veterinary Sciences

Apparent ivermectin resistance if Parascaris equorum in foals in Denmark

H. Schougaard et al.

VETERINARY RECORD (2007)

Article Veterinary Sciences

Evidence of ivermectin resistance by Parascaris equorum on a Texas horse farm

T. M. Craig et al.

JOURNAL OF EQUINE VETERINARY SCIENCE (2007)

Article Veterinary Sciences

A field study on the effect of some anthelmintics on cyathostomins of horses in Sweden

E. Osterman Lind et al.

VETERINARY RESEARCH COMMUNICATIONS (2007)

Article Parasitology

Cyathostomes in horses in Canada resistant to pyrantel salts and effectively removed by moxidectin

J. Owen D. Slocombe et al.

VETERINARY PARASITOLOGY (2006)

Article Veterinary Sciences

Anthelmintic use and resistance on thoroughbred training yards in the UK

KC Comer et al.

VETERINARY RECORD (2006)

Letter Veterinary Sciences

Ivermectin resistance in Parascaris equorum

S Stoneham et al.

VETERINARY RECORD (2006)

Article Veterinary Sciences

Pyrantel pamoate resistance in horses receiving daily administration of pyrantel tartrate

EL Brazik et al.

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2006)

Article Veterinary Sciences

Equine strongyles - II. Occurrence of anthelmintic resistance in Switzerland

A Meier et al.

SCHWEIZER ARCHIV FUR TIERHEILKUNDE (2005)

Article Veterinary Sciences

Prevalence of benzimidazole resistance on horse farms in Germany

N Wirtherle et al.

VETERINARY RECORD (2004)

Review Parasitology

Drug resistance in nematodes of veterinary importance: a status report

RM Kaplan

TRENDS IN PARASITOLOGY (2004)

Article Veterinary Sciences

Prevalence of anthelmintic resistant cyathostomes on horse farms

RM Kaplan et al.

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2004)

Article Veterinary Sciences

Management of drug-resistant cyathostominosis on a breeding farm in central North Carolina

D Little et al.

EQUINE VETERINARY JOURNAL (2003)

Article Veterinary Sciences

Identification of foals infected with Parascaris equorum apparently resistant to ivermectin

FPD Hearn et al.

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2003)

Article Parasitology

A survey of helminth control practices in equine establishments in Ireland

B O'Meara et al.

VETERINARY PARASITOLOGY (2002)

Review Veterinary Sciences

Anthelmintic resistance in nematodes of horses

RM Kaplan

VETERINARY RESEARCH (2002)

Article Veterinary Sciences

Apparent resistance of Parascaris equorum to macrocylic lactones

JH Boersema et al.

VETERINARY RECORD (2002)

Article Veterinary Sciences

Prevalence and clinical implications of anthelmintic resistance in cyathostomes of horses

JL Tarigo-Martinie et al.

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2001)

Article Parasitology

Benzimidazole resistance in equine cyathostomes in Slovakia

M Várady et al.

VETERINARY PARASITOLOGY (2000)