4.2 Article

Cold AIHA and the best treatment strategies

Related references

Note: Only part of the references are listed.
Article Hematology

Sutimlimab in patients with cold agglutinin disease results of the randomized placebo-controlled phase 3 CADENZA trial

Alexander Roeth et al.

Summary: Sutimlimab, a humanized monoclonal antibody, shows potential as an important advancement in the treatment of cold agglutinin disease (CAD) by selectively inhibiting the classical complement pathway and rapidly halting hemolysis.

BLOOD (2022)

Review Hematology

How I treat cold agglutinin disease

Sigbjorn Berentsen

Summary: Significant progress has been made in the treatment of CAD in recent decades, with recommendations mainly based on nonrandomized trials and personal experience due to the lack of comparative trials. Individualized treatment options tailored to patients' symptoms and disease characteristics are crucial to avoid ineffective therapies.

BLOOD (2021)

Article Immunology

The Immunomodulatory Effect and Clinical Efficacy of Daratumumab in a Patient With Cold Agglutinin Disease

Anna Zaninoni et al.

Summary: Daratumumab, a monoclonal antibody targeting CD38, has shown efficacy in multiple myeloma and is now being investigated for its potential in treating autoimmune conditions like cold agglutinin disease. The drug not only depletes plasma cells but also demonstrates immunomodulatory effects by influencing the levels of various cytokines. Research also suggests its potential in refractory autoimmune hemolytic anemia, Evans syndrome, and other autoimmune diseases.

FRONTIERS IN IMMUNOLOGY (2021)

Article Medicine, General & Internal

Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

Peter Hillmen et al.

Summary: The study demonstrated that Pegcetacoplan was superior to eculizumab in improving hemoglobin and clinical and hematologic outcomes in patients with PNH by providing broad hemolysis control, including control of intravascular and extravascular hemolysis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Sutimlimab in Cold Agglutinin Disease

Alexander Roeth et al.

Summary: In patients with cold agglutinin disease, treatment with sutimlimab rapidly halted hemolysis, increased hemoglobin levels, and reduced fatigue by selectively inhibiting activity in the classic complement pathway.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Editorial Material Hematology

Cold agglutinins: fending off the attack

Sigbjorn Berentsen

BLOOD (2019)

Article Oncology

Primary and Secondary Immune Cytopenias Evaluation and Treatment Approach in Children

Taylor Olmsted Kim et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2019)

Review Hematology

How I manage patients with cold agglutinin disease

Sigbjorn Berentsen

BRITISH JOURNAL OF HAEMATOLOGY (2018)

Article Hematology

How I treat autoimmune hemolytic anemia

Ronald S. Go et al.

BLOOD (2017)

Review Hematology

Cold agglutinin disease

Paul L. Swiecicki et al.

BLOOD (2013)

Article Medicine, General & Internal

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic-Uremic Syndrome

C. M. Legendre et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Pediatrics

Diagnosis and Management of Autoimmune Cytopenias in Childhood

David T. Teachey et al.

PEDIATRIC CLINICS OF NORTH AMERICA (2013)

Review Hematology

Diagnosis and treatment of cold agglutinin mediated autoimmune hemolytic anemia

Sigbjorn Berentsen et al.

BLOOD REVIEWS (2012)

Article Medicine, General & Internal

The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria

Peter Hillmen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Immunology

Acute phase haemolysis in chronic cold agglutinin disease

E Ulvestad et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2001)