4.7 Article

Effect of the At-CDC27a gene on Nicotiana benthamiana phenotype and accumulation of recombinant proteins

Related references

Note: Only part of the references are listed.
Article Plant Sciences

CRISPR/Cas9-mediated knockout of the DCL2 and DCL4 genes in Nicotiana benthamiana and its productivity of recombinant proteins

Kouki Matsuo

Summary: Key message DCL2 and DCL4 genes in Nicotiana benthamiana plants were successfully edited using the CRISPR/Cas9 system, resulting in double-knockout transgenic plants that accumulated higher amounts of protein and mRNA. These plants may be suitable for recombinant protein production.

PLANT CELL REPORTS (2022)

Review Plant Sciences

Plant molecular farming for the production of valuable proteins ? Critical evaluation of achievements and future challenges

Stefan Schillberg et al.

Summary: This article discusses the importance of recombinant proteins in various fields such as food, chemical, and pharmaceutical industries, as well as the development of molecular farming as a production platform. With molecular farming products gradually entering the market, but limited by various factors, success stories remain relatively few.

JOURNAL OF PLANT PHYSIOLOGY (2021)

Review Plant Sciences

The Role of Anaphase-Promoting Complex/Cyclosome (APC/C) in Plant Reproduction

Marina de Lyra Soriano Saleme et al.

Summary: Most eukaryotic species propagate through sexual reproduction involving male and female gametes. In flowering plants, this process begins with DNA replication and chromosome segregation, followed by mitotic divisions to form male and female gametophytes. Precise regulation of gametogenesis progression is essential for successful meiotic cell division and sexual differentiation in plant species.

FRONTIERS IN PLANT SCIENCE (2021)

Article Plant Sciences

At-CycD2 Enhances Accumulation of Above-Ground Biomass and Recombinant Proteins in Transgenic Nicotiana benthamiana Plants

Lilya Kopertekh et al.

Summary: Transient expression in Nicotiana benthamiana was enhanced by transforming the At-CycD2 gene, resulting in increased leaf and stem biomass fractions. The transgenic line At-CycD2-15 showed accelerated above-ground biomass accumulation and enlarged leaf area, attributed to an increase in epidermal cell number compensated by slightly reduced cell size. The production capacity of At-CycD2-15 line for transiently expressed proteins was significantly higher compared to the wild type, demonstrating the potential of the cell cycle regulator gene At-CycD2 in enhancing recombinant protein yield.

FRONTIERS IN PLANT SCIENCE (2021)

Review Biochemical Research Methods

Proteases of Nicotiana benthamiana: an emerging battle for molecular farming

Philippe V. Jutras et al.

CURRENT OPINION IN BIOTECHNOLOGY (2020)

Review Biochemical Research Methods

Innovation in plant-based transient protein expression for infectious disease prevention and preparedness

Frank Sainsbury

CURRENT OPINION IN BIOTECHNOLOGY (2020)

Review Biochemistry & Molecular Biology

Transient Production of Recombinant Pharmaceutical Proteins in Plants: Evolution and Perspectives

Lilya Kopertekh et al.

CURRENT MEDICINAL CHEMISTRY (2019)

Article Plant Sciences

Critical Analysis of the Commercial Potential of Plants for the Production of Recombinant Proteins

Stefan Schillberg et al.

FRONTIERS IN PLANT SCIENCE (2019)

Review Plant Sciences

The Rise and Rise of Nicotiana benthamiana: A Plant for All Reasons

Julia Bally et al.

ANNUAL REVIEW OF PHYTOPATHOLOGY, VOL 56 (2018)

Article Biotechnology & Applied Microbiology

Repression of the DCL2 and DCL4 genes in Nicotiana benthamiana plants for the transient expression of recombinant proteins

Kouki Matsuo et al.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2017)

Review Multidisciplinary Sciences

Plant-produced biopharmaceuticals: A case of technical developments driving clinical deployment

George P. Lomonossoff et al.

SCIENCE (2016)

Review Plant Sciences

Tackling Unwanted Proteolysis in Plant Production Hosts Used for Molecular Farming

Manoj K. Mandal et al.

FRONTIERS IN PLANT SCIENCE (2016)

Review Biotechnology & Applied Microbiology

Environment Control to Improve Recombinant Protein Yields in Plants Based on Agrobacterium-Mediated Transient Gene Expression

Naomichi Fujiuchi et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2016)

Article Biotechnology & Applied Microbiology

Leaf proteome rebalancing in Nicotiana benthamiana for upstream enrichment of a transiently expressed recombinant protein

Stephanie Robert et al.

PLANT BIOTECHNOLOGY JOURNAL (2015)

Article Biochemistry & Molecular Biology

Techno-Economic Analysis of Horseradish Peroxidase Production Using a Transient Expression System in Nicotiana benthamiana

David Richard Walwyn et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2015)

Article Biochemistry & Molecular Biology

CDC48 function during TMV infection Regulation of virus movement and replication by degradation?

Annette Niehl et al.

PLANT SIGNALING & BEHAVIOR (2013)

Review Biochemistry & Molecular Biology

The Anaphase-Promoting Complex/Cyclosome in Control of Plant Development

Jefri Heyman et al.

MOLECULAR PLANT (2012)

Article Multidisciplinary Sciences

Structural basis for the subunit assembly of the anaphase-promoting complex

Anne Schreiber et al.

NATURE (2011)

Review Biology

Structural insights into anaphase-promoting complex function and mechanism

David Barford

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2011)

Article Biochemistry & Molecular Biology

Overexpression of the Arabidopsis anaphase promoting complex subunit CDC27a increases growth rate and organ size

Cristian Antonio Rojas et al.

PLANT MOLECULAR BIOLOGY (2009)

Review Biochemistry & Molecular Biology

Nicotiana benthamiana:: Its history and future as a model for plant-pathogen interactions

Michael M. Goodin et al.

MOLECULAR PLANT-MICROBE INTERACTIONS (2008)

Review Cell Biology

The anaphase promoting complex/cyclosome: a machine designed to destroy

Jan-Michael Peters

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Multidisciplinary Sciences

Cyclin D control of growth rate in plants

CE Cockcroft et al.

NATURE (2000)