Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues

Botanical pesticides are one of the sources of third-generation pesticides, which have received much attention at home and abroad in recent years due to their degradable and pollution-free advantages in nature. This article explored a concise approach toward synthesizing a series of novel L-pyroglutamic acid analogues from L-hydroxyproline. Furthermore, bioassay studies of these sulfonyl ester derivatives against Pyricularia oryzae, Fusarium graminearum, Alternaria brassicae, Valsa mali, and Alternaria alternariae showed moderate antifungal activity. For instance, C08a and C08l provide potential lead agents for controlling Fusarium graminearum because of their inhibitory activity.

Automated summary

Botanical pesticides are a potential source of third-generation pesticides. This article explores a concise method to synthesize novel L-pyroglutamic acid analogues, and bioassay studies demonstrate their moderate antifungal activity against several fungal pathogens.