☆ 4.6 Article

Vitamin D alleviates non-alcoholic fatty liver disease via restoring gut microbiota and metabolism

FRONTIERS IN MICROBIOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Microbiology

Human gut bacterial metabolism drives Th17 activation and colitis

Margaret Alexander et al.

Summary: The activation of Th17 cells by human gut bacteria Eggerthella lenta exacerbates inflammatory bowel disease. Variations in E. lenta strains and the Cgr2 enzyme contribute to Th17 cell activation. Blocking E. lenta-induced intestinal inflammation is crucial for preventing the development of autoimmune diseases.

CELL HOST & MICROBE (2022)

Add to Collection

Article Microbiology

Host hepatic metabolism is modulated by gut microbiota-derived sphingolipids

Henry H. Le et al.

Summary: Microbially-derived gut metabolites play an important role in host phenotypes. This study traces bacterial sphingolipids from gut symbiont Bacteroides thetaiotaomicron to mouse colons and livers, and finds that bacterial sphingolipid synthesis can rescue excess lipid accumulation in a mouse model of hepatic steatosis. The transfer of this sphingolipid to the liver potentially contributes to microbiota-mediated liver function.

CELL HOST & MICROBE (2022)

Add to Collection

Article Gastroenterology & Hepatology

Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective

Kylynda C. Bauer et al.

Summary: Nonalcoholic fatty liver disease is a common chronic condition associated with obesity and metabolic syndrome, but it is also influenced by undernutrition and dysbiotic gut microbiome. The relationship between undernutrition and NAFLD is not well studied. This review discusses the features of fatty liver in undernutrition conditions and the gut microbiota-liver axis, highlighting key pathways in NAFLD progression under both overnutrition and undernutrition. The challenges and collaborative possibilities in emerging multiomic research for the pathology and treatment of undernourished NAFLD are also identified.

GASTROENTEROLOGY (2022)

Add to Collection

Article Cell Biology

Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection

Rui Sun et al.

Summary: This study reveals the critical role of Neutral ceramidase (NcDase) in regulating intestinal immune cells. Lack of NcDase leads to altered composition of intestinal immune cells and impairs the clearance of bacteria in mice. Mechanistically, the generation of sphingosine by NcDase promotes immune response in macrophages. Furthermore, dietary sphingomyelin and inhibition of SphK1 can protect against infection.

CELL REPORTS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Mendelian Randomization Analysis Identifies Blood Tyrosine Levels as a Biomarker of Non-Alcoholic Fatty Liver Disease

Emilie Gobeil et al.

Summary: This study found a potential causal effect of NAFLD on blood tyrosine levels, suggesting it may serve as a new biomarker for NAFLD.

METABOLITES (2022)

Add to Collection

Article Nutrition & Dietetics

Identification and Spatial Visualization of Dysregulated Bile Acid Metabolism in High-Fat Diet-Fed Mice by Mass Spectral Imaging

Qi Zhang et al.

Summary: Changes in bile acid levels and metabolites are involved in metabolic diseases and gastrointestinal and liver cancer. Currently, there is no available method to detect the spatial distribution and molecular profiling of bile acids. Mass spectrometry imaging with high spatial resolution has been shown to be a valuable tool in investigating and locating bile acid molecules in different tissue types.

FRONTIERS IN NUTRITION (2022)

Add to Collection

Article Microbiology

Roux-en-Y gastric bypass-induced perturbative changes in microbial communities and metabolic pathways in rats

Jing Yang et al.

Summary: This study compared the changes in gut microbiota after sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) surgeries. It was found that RYGB significantly reduced the diversity of gut microbiota and increased the proportion of Escherichia, Bacteroides, and Akkermansia genera. Metabolic pathway enrichment and integrated analysis also revealed that RYGB can induce changes in microbial communities and metabolic pathways, suggesting its potential for improving metabolic disease intervention through bacterial-metabolite crosstalk.

FRONTIERS IN MICROBIOLOGY (2022)

Add to Collection

Article Cell Biology

Risk assessment with gut microbiome and metabolite markers in NAFLD development

Howell Leung et al.

Summary: A growing body of evidence suggests that the gut microbiota plays a role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). This study found that machine learning models integrating microbial signatures were able to accurately classify individuals based on their NAFLD status and liver fat accumulation, outperforming other clinical models. These findings raise the possibility of using gut microbiota for early clinical warning of NAFLD development.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Add to Collection

Article Microbiology

Characterization of inositol lipid metabolism in gut-associated Bacteroidetes

Stacey L. Heaver et al.

Summary: This study characterizes the pathways responsible for inositol lipid production in human gut Bacteroides and explores the importance of these lipids for capsule expression, antimicrobial peptide resistance, and colonization. The authors identify the biosynthetic pathway and enzymes involved in inositol lipid synthesis, and show that loss of inositol lipid production affects bacterial fitness and symbiosis in a mouse model. They also discover a previously undescribed pathway for bacterial PI-DAG synthesis. Overall, the findings suggest that inositol sphingolipid production is widespread in host-associated Bacteroidetes and has implications for symbiotic relationships.

NATURE MICROBIOLOGY (2022)

Add to Collection

Article Nutrition & Dietetics

Interplay between dietary intake, gut microbiota, and metabolic profile in obese adolescents: Sex-dependent differential patterns

Yang Liu et al.

Summary: This study aimed to explore the unique profiles of gut bacterial, gut metabolites, and circulating metabolites in adolescents of both genders based on BMI and eating patterns.

CLINICAL NUTRITION (2022)

Add to Collection

Article Microbiology

Altered Gut Microbial Profile Accompanied by Abnormal Fatty Acid Metabolism Activity Exacerbates Endometrial Cancer Progression

Shan-Shan Zhao et al.

Summary: This study explored the relationship between gut microbiota dysbiosis and endometrial cancer (EC) progression. The results showed differential profiles of gut microbiota between EC patients and normal participants, and the association between gut microbiota and EC progression. Furthermore, targeted metabolomics revealed increased levels of specific metabolites positively associated with the abundance of Ruminococcus sp. N15.MGS-57. Imaging mass microscopy characterized alterations in fatty acids in tumor tissue, suggesting a potential role of C16:1 in promoting EC cell invasion and metastasis through mTOR signaling. The aberrant fecal microbiome and spatial distribution of specific metabolites may serve as biomarkers for clinical features and outcomes, as well as provide a new therapeutic target for EC treatment.

MICROBIOLOGY SPECTRUM (2022)

Add to Collection

Article Gastroenterology & Hepatology

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

Xiang Zhang et al.

Summary: High dietary cholesterol leads to sequential progression of steatosis, steatohepatitis, fibrosis and eventually HCC in mice, concomitant with insulin resistance. Cholesterol-induced NAFLD-HCC formation is associated with gut microbiota dysbiosis, with specific bacterial composition changes between stages of liver disease. Alterations in gut bacterial metabolites were also observed with dietary cholesterol intake. Therapies targeting cholesterol and gut microbiota may be effective for preventing NAFLD-HCC.

GUT (2021)

Add to Collection

Article Gastroenterology & Hepatology

Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury

Laura Wrzosek et al.

Summary: This study demonstrates that targeting the intestinal microbiota can improve alcoholic liver disease, with a key role played by the aryl hydrocarbon receptor (AhR) pathway.

GUT (2021)

Add to Collection

Article Oncology

Lactobacillus lactis and Pediococcus pentosaceus-driven reprogramming of gut microbiome and metabolome ameliorates the progression of non-alcoholic fatty liver disease

Jeong Seok Yu et al.

Summary: The supplementation of L. lactis and P. pentosaceus effectively improved the condition of NAFLD mice, restoring key metabolic features such as short chain fatty acids (SCFAs), bile acids (BAs), and tryptophan metabolites. This protective effect was also observed in NAFLD patients, with a significantly higher Firmicutes/Bacteroidetes ratio compared to the control group. Furthermore, a panel of six stool metabolites including indole, BAs, and SCFAs showed promising results in diagnosing NAFLD with an area under the curve of 0.922. Overall, NAFLD progression is closely associated with metabolic dysregulations in SCFAs, bile acid, and indole compounds, with the potential for accurate diagnosis using metabolites.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Vitamin D ameliorates high-fat-diet-induced hepatic injury via inhibiting pyroptosis and alters gut microbiota in rats

Xiaolei Zhang et al.

Summary: Accumulating evidence suggests that vitamin D has a therapeutic effect on non-alcoholic fatty liver disease (NAFLD) by inhibiting pyroptosis and restoring gut microbiota balance, providing a novel mechanism for VD therapy against NAFLD.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

Add to Collection

Correction Multidisciplinary Sciences

Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations (vol 12, 4845, 2021)

Martin Strazar et al.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Microbiology

Eicosapentaenoic and docosahexaenoic acids attenuate hyperglycemia through the microbiome-gut-organs axis in db/db mice

Pan Zhuang et al.

Summary: The study found that DHA and EPA can significantly alleviate hyperglycemia and insulin resistance by altering the gut microbiome and metabolites, thereby improving symptoms of diabetes, with EPA showing a more pronounced effect.

MICROBIOME (2021)

Add to Collection

Article Microbiology

Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype

Jia V. Li et al.

Summary: Bariatric surgery, especially Roux-en-Y gastric bypass (RYGB), has a significant impact on the metabolism and gut microbiota of patients, leading to changes in metabolites and bacterial composition that are associated with successful weight loss and metabolic improvements. Further research is needed to understand the functional clinical outcomes of these metabolic changes.

MICROBIOME (2021)

Add to Collection

Article Microbiology

Gut Microbiota Serves a Predictable Outcome of Short-Term Low-Carbohydrate Diet (LCD) Intervention for Patients with Obesity

Susu Zhang et al.

Summary: This study demonstrates the impact of gut microbiota on the efficacy of a low-carbohydrate diet (LCD). After 12 weeks of LCD intervention, the relative abundance of butyrate-producing bacteria significantly increased, and participants with a higher relative abundance of Bacteroidaceae Bacteroides at baseline showed better response to the intervention. Additionally, an artificial neural network prediction model outperformed a general linear model in predicting weight loss outcomes after LCD intervention.

MICROBIOLOGY SPECTRUM (2021)

Add to Collection

Article Gastroenterology & Hepatology

Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome

Clara Depommier et al.

Summary: The reduction of A. muciniphila in the gut microbiota is associated with obesity-related metabolic disorders. Metabolomics profiling revealed that administration of different forms of A. muciniphila can lead to alterations in amino acid metabolism and induction of ketogenesis through enhanced beta-oxidation. Additionally, certain metabolites emerged as significant compounds related to health and diseases.

GUT MICROBES (2021)

Add to Collection

Article Endocrinology & Metabolism

Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation

Ana Andres-Hernando et al.

Summary: Umami foods, containing monosodium glutamate and inosine monophosphate, may induce metabolic syndrome in mice by activating purine degradation pathway in the liver and brain, leading to the formation of uric acid.

NATURE METABOLISM (2021)

Add to Collection

Review Endocrinology & Metabolism

Obesity: a neuroimmunometabolic perspective

Chelsea M. Larabee et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

Add to Collection

Article Gastroenterology & Hepatology

TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice

Mingming Zhao et al.

GASTROENTEROLOGY (2020)

Add to Collection

Article Gastroenterology & Hepatology

Nonalcoholic fatty liver disease: modulating gut microbiota to improve severity?

Judith Aron-Wisnewsky et al.

GASTROENTEROLOGY (2020)

Add to Collection

Article Gastroenterology & Hepatology

Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

Silvia Sookoian et al.

GUT (2020)

Add to Collection

Article Gastroenterology & Hepatology

Indole Alleviates Diet-Induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3

Linqiang Ma et al.

HEPATOLOGY (2020)

Add to Collection

Article Gastroenterology & Hepatology

Lactobacillus and Pediococcus ameliorate progression of non-alcoholic fatty liver disease through modulation of the gut microbiome

Na Young Lee et al.

GUT MICROBES (2020)

Add to Collection

Article Multidisciplinary Sciences

Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

Elizabeth L. Johnson et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Review Gastroenterology & Hepatology

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

Judith Aron-Wisnewsky et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Add to Collection

Article Neurosciences

Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity

Ana B. Fernandes et al.

NEURON (2020)

Add to Collection

Article Multidisciplinary Sciences

Vitamin D metabolites and the gut microbiome in older men

Robert L. Thomas et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Correction Cell Biology

A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis (vol 32, pg 878, 2020)

Tae Gyu Oh et al.

CELL METABOLISM (2020)

Add to Collection

Review Gastroenterology & Hepatology

Pediatric NAFLD: an overview and recent developments in diagnostics and treatment

Laura Draijer et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2019)

Add to Collection

Review Endocrinology & Metabolism

Aligning the Paradoxical Role of Vitamin D in Gastrointestinal Immunity

Margherita T. Cantorna et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

Add to Collection

Article Gastroenterology & Hepatology

Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease

Jeffrey B. Schwimmer et al.

GASTROENTEROLOGY (2019)

Add to Collection

Article Endocrinology & Metabolism

Melatonin safeguards against fatty liver by antagonizing TRAFs-mediated ASK1 deubiquitination and stabilization in a β-arrestin-1 dependent manner

Dong-Jie Li et al.

JOURNAL OF PINEAL RESEARCH (2019)

Add to Collection

Article Multidisciplinary Sciences

Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

Junki Miyamoto et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Bach2 deficiency leads autoreactive B cells to produce IgG autoantibodies and induce lupus through a T cell-dependent extrafollicular pathway

Eunkyeong Jang et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

Add to Collection

Article Gastroenterology & Hepatology

Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus

Jinfeng Wang et al.

GUT (2018)

Add to Collection

Article Cell Biology

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

Smitha Krishnan et al.

CELL REPORTS (2018)

Add to Collection

Article Cell Biology

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

Jane M. Natividad et al.

CELL METABOLISM (2018)

Add to Collection

Article Gastroenterology & Hepatology

Gut Microbiota Profiling of Pediatric Nonalcoholic Fatty Liver Disease and Obese Patients Unveiled by an Integrated Meta-omics-Based Approach

Federica Del Chierico et al.

HEPATOLOGY (2017)

Add to Collection

Editorial Material Medicine, General & Internal

The Microbiome and Risk for Obesity and Diabetes

Anthony L. Komaroff

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

Add to Collection

Article Oncology

Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation

Lili Sheng et al.

JOURNAL OF PATHOLOGY (2017)

Add to Collection

Article Cell Biology

The endocrine vitamin D system in the gut

Antonio Barbachano et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2017)

Add to Collection

Article Gastroenterology & Hepatology

Functional analysis of the relationship between intestinal microbiota and the expression of hepatic genes and pathways during the course of liver regeneration

Hui-Xin Liu et al.

JOURNAL OF HEPATOLOGY (2016)

Add to Collection

Article Genetics & Heredity

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

Jun Wang et al.

NATURE GENETICS (2016)

Add to Collection

Article Medicine, General & Internal

Nonalcoholic fatty liver disease

Elizabeth M. Brunt et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Add to Collection

Article Oncology

Bile Acids Regulate Nuclear Receptor (Nur77) Expression and Intracellular Location to Control Proliferation and Apoptosis

Ying Hu et al.

MOLECULAR CANCER RESEARCH (2015)

Add to Collection

Article Gastroenterology & Hepatology

Intestinal Microbiota in Patients With Nonalcoholic Fatty Liver Disease

Marialena Mouzaki et al.

HEPATOLOGY (2013)

Add to Collection

Letter Biochemical Research Methods

QIIME allows analysis of high-throughput community sequencing data

J. Gregory Caporaso et al.

NATURE METHODS (2010)

Add to Collection

© Peeref 2019-2024. All rights reserved.