4.6 Article

Identification and analysis of the interaction network of African swine fever virus D1133L with host proteins

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

African swine fever virus cysteine protease pS273R inhibits pyroptosis by noncanonically cleaving gasdermin D

Gaihong Zhao et al.

Summary: Research has found that the pyroptosis execution protein gasdermin D (GSDMD) is a new binding partner of ASFV-encoded protein S273R (pS273R). Further experiments showed that pS273R can cleave swine GSDMD, producing a shorter N-terminal fragment that does not trigger pyroptosis or inhibit ASFV replication. This discovery reveals a previously unrecognized mechanism involved in the inhibition of pyroptosis induced by ASFV infection.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Article Microbiology

MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway

Keshan Zhang et al.

Summary: This study identified the function of MGF360-9L protein during ASFV infection. MGF360-9L inhibits IFN-beta signaling through the degradation of STAT1 and STAT2 and is an important virulence gene of ASFV. These findings may guide the development of live attenuated ASFV vaccines.
Article Immunology

African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3

Yang Wang et al.

Summary: This study discovered that the non-structural protein MGF360-14L of African swine fever virus inhibits interferon production by interfering with the host immune system. The study also revealed that MGF360-14L interacts with and degrades the IRF3 protein, further suppressing immune response.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Review Cell Biology

Roles of vimentin in health and disease

Karen M. Ridge et al.

Summary: This review discusses the essential functions of vimentin intermediate filaments (IFs) revealed from studies of Vim(-/-) mice and cells derived from them. It has been found that Vim(-/-) mice and their organs, tissues, and cells exhibit various phenotypes, frequently reflecting altered responses in tissue recovery. Cell-based experiments have confirmed the critical role of vimentin IFs in regulating cell mechanics.

GENES & DEVELOPMENT (2022)

Article Immunology

African swine fever control and prevention: an update on vaccine development

Ana Catarina Urbano et al.

Summary: African swine fever (ASF) is a lethal and highly contagious viral disease that poses a serious threat to the global swine industry. Although progress has been made in vaccine development, there are still challenges to overcome, such as cross-protection, safety, and the lack of suitable animal models.

EMERGING MICROBES & INFECTIONS (2022)

Article Virology

FoxJ1 inhibits African swine fever virus replication and viral S273R protein decreases the expression of FoxJ1 to impair its antiviral effect

Caina Ma et al.

Summary: African swine fever (ASF) is a highly pathogenic disease that affects domestic and wild pigs. There is currently no effective vaccine available. This study found that the host factor FoxJ1 plays a role in inhibiting ASFV replication, while ASFV proteins degrade FoxJ1, weakening its antiviral effect. These findings provide insights for the development of antiviral drugs and vaccines against ASFV infection.

VIROLOGICA SINICA (2022)

Article Veterinary Sciences

African swine fever virus MGF360-11L negatively regulates cGAS-STING-mediated inhibition of type I interferon production

Kaidian Yang et al.

Summary: This study demonstrated that ASFV MGF360-11L protein plays a significant role in inhibiting the antiviral activity mediated by IFN-I through regulating the cGAS signaling pathway. These findings expand our understanding of the molecular mechanism of ASFV MGF360-11L protein and provide new strategies for the treatment and prevention of ASF.

VETERINARY RESEARCH (2022)

Review Cell Biology

Host-virus interaction and viral evasion

Scheilla T. Strumillo et al.

Summary: Viruses, as obligate intracellular parasites, continually evolve during infection to manipulate the cellular environment and evade the host immune response. Developing new therapeutic strategies targeting viral dissemination, such as antiviral therapies, vaccines, and antioxidants, as well as inhibiting or activating altered cell signaling pathways or metabolic pathways, is crucial to control viral diseases. Achieving rapid recovery of altered cellular homeostasis during viral infection remains a major challenge in the medical community.

CELL BIOLOGY INTERNATIONAL (2021)

Review Veterinary Sciences

Review of African swine fever outbreaks history in South Africa: From 1926 to 2018

Ciza A. Mushagalusa et al.

Summary: The article discusses the history of African swine fever outbreaks in South Africa, analyzing data before and after the development of the OIE diseases database. It highlights the seasonality of outbreaks, with more occurring in summer, and the identification of nine p72 genotypes in South Africa. The study also emphasizes the need for spatiotemporal studies to assess the clustering of outbreaks accurately.

ONDERSTEPOORT JOURNAL OF VETERINARY RESEARCH (2021)

Article Virology

Identification and Characterization of a Novel Epitope of ASFV-Encoded dUTPase by Monoclonal Antibodies

Shuai Zhang et al.

Summary: The study successfully developed specific monoclonal antibodies targeting ASFV dUTPase, and identified an important antibody-binding antigenic epitope in the V region of ASFV dUTPase. These findings may contribute to the development of novel antibody-based therapeutic approaches for ASFV.

VIRUSES-BASEL (2021)

Article Virology

TRIM21 inhibits porcine epidemic diarrhea virus proliferation by proteasomal degradation of the nucleocapsid protein

Hua Wang et al.

Summary: The study reveals that TRIM21 inhibits the proliferation of PEDV by degrading the N protein, with its overexpression suppressing viral replication and knockdown leading to increased viral titers and N protein levels. TRIM21 interacts with and colocalizes with the N protein, and its antiviral effect is dependent on its ubiquitin ligase activity, which leads to the polyubiquitination and degradation of the N protein in a proteasome-dependent manner.

ARCHIVES OF VIROLOGY (2021)

Article Microbiology

Vimentin rearrangement by phosphorylation is beneficial for porcine reproductive and respiratory syndrome virus replication in vitro

Xin-Xian Zheng et al.

Summary: This study identified a previously unrecognized role of vimentin rearrangement in PRRSV replication. It was found that PRRSV infection induced vimentin reorganization, which was beneficial for viral replication by forming cage-like structures enwrapping PRRSV replication complex. These results expand the knowledge of PRRSV replication and offer new targets for prevention and control of PRRSV.

VETERINARY MICROBIOLOGY (2021)

Article Virology

Construction, Identification and Analysis of the Interaction Network of African Swine Fever Virus MGF360-9L with Host Proteins

Bo Yang et al.

Summary: The study identified interactions between ASFV MGF360-9L protein and numerous other proteins in porcine kidney cells, with implications in protein binding, metabolism, and immune response. Overexpression of certain proteins like PSMA3 and PSMC1 significantly promoted ASFV replication, shedding light on potential mechanisms of viral pathogenesis.

VIRUSES-BASEL (2021)

Article Microbiology

African Swine Fever Virus Induces STAT1 and STAT2 Degradation to Counteract IFN-I Signaling

Elena Riera et al.

Summary: Infection with ASFV strains both virulent and attenuated have been shown to prevent interferon-stimulated gene expression in interferon-treated cells by counteracting the JAK/STAT signaling pathway. Two independent mechanisms of control of the JAK/STAT pathway suggest the importance of preventing this pathway for successful viral replication. Understanding these IFN antagonistic properties may lead to new strategies to control ASFV.

FRONTIERS IN MICROBIOLOGY (2021)

Review Immunology

Structure of African Swine Fever Virus and Associated Molecular Mechanisms Underlying Infection and Immunosuppression: A Review

Yue Wang et al.

Summary: African swine fever (ASF) is an acute, highly contagious, and deadly infectious disease with almost 100% mortality rate. The ASFV, which causes ASF, is a unique DNA virus with insect-borne transmission and there are no effective vaccines or antiviral drugs for prevention or treatment. The complexity of viral genome and its strong ability to regulate host immune response make vaccine development challenging.

FRONTIERS IN IMMUNOLOGY (2021)

Review Veterinary Sciences

African Swine Fever Virus: An Emerging DNA Arbovirus

Natasha N. Gaudreault et al.

FRONTIERS IN VETERINARY SCIENCE (2020)

Review Biochemistry & Molecular Biology

Transcriptome view of a killer: African swine fever virus

Gwenny Cackett et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2020)

Article Biochemical Research Methods

Host cell interactome of PB1 N40 protein of H5N1 influenza A virus in chicken cells

Qiao Wang et al.

JOURNAL OF PROTEOMICS (2019)

Article Multidisciplinary Sciences

Architecture of African swine fever virus and implications for viral assembly

Nan Wang et al.

SCIENCE (2019)

Article Virology

Virus DNA Replication and the Host DNA Damage Response

Matthew D. Weitzman et al.

ANNUAL REVIEW OF VIROLOGY, VOL 5 (2018)

Article Infectious Diseases

Emergence of African Swine Fever in China, 2018

Xintao Zhou et al.

TRANSBOUNDARY AND EMERGING DISEASES (2018)

Review Virology

African Swine Fever Virus: A Review

Inmaculada Galindo et al.

VIRUSES-BASEL (2017)

Review Biochemistry & Molecular Biology

Distinct RNA-unwinding mechanisms of DEAD-box and DEAH-box RNA helicase proteins in remodeling structured RNAs and RNPs

Benjamin Gilman et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2017)

Review Veterinary Sciences

African swine fever: a global view of the current challenge

Ma Carmen Gallardo et al.

PORCINE HEALTH MANAGEMENT (2015)

Article Biochemical Research Methods

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

Linn Fagerberg et al.

MOLECULAR & CELLULAR PROTEOMICS (2014)

Article Medicine, Research & Experimental

A179L, a New Viral Bcl2 Homolog Targeting Beclin 1 Autophagy Related Protein

B. Hernaez et al.

CURRENT MOLECULAR MEDICINE (2013)

Article Biochemistry & Molecular Biology

Unwinding Initiation by the Viral RNA Helicase NPH-II

Margaret E. Fairman-Williams et al.

JOURNAL OF MOLECULAR BIOLOGY (2012)

Article Cell Biology

Spliceosome Structure and Function

Cindy L. Will et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Article Microbiology

Regulation of Host Translational Machinery by African Swine Fever Virus

Alfredo Castello et al.

PLOS PATHOGENS (2009)

Article Biochemical Research Methods

Rapid human metapneumovirus microneutralization assay based on green fluorescent protein expression

S Biacchesi et al.

JOURNAL OF VIROLOGICAL METHODS (2005)

Article Biochemistry & Molecular Biology

An error-prone viral DNA ligase

BJ Lamarche et al.

BIOCHEMISTRY (2005)

Article Cell Biology

Aggresomes resemble sites specialized for virus assembly

CM Heath et al.

JOURNAL OF CELL BIOLOGY (2001)

Article Multidisciplinary Sciences

The DExH protein NPH-II is a processive and directional motor for unwinding RNA

E Jankowsky et al.

NATURE (2000)