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Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2

FRONTIERS IN MICROBIOLOGY (2022)

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Cognitive impairment and a ered cerebral glucose metabolism in the subacute stage of COVID-19

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SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment

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SARS-CoV-2 infection induces beta cell transdifferentiation

Xuming Tang et al.

Summary: Recent clinical data suggest a correlation between COVID-19 and diabetes. This study found SARS-CoV-2 viral antigen in pancreatic beta cells, leading to the possibility of cell transdifferentiation. Infection with SARS-CoV-2 can cause changes in cell fate, providing new insights into the pathomechanisms of COVID-19.

CELL METABOLISM (2021)

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Article Gastroenterology & Hepatology

Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy

Matthew J. McConnell et al.

Summary: Analysis of COVID-19 patients suggests that IL-6 trans-signaling may cause hepatic endotheliopathy and blood clot formation, leading to liver injury.

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The Cys Sense: Thiol Redox Switches Mediate Life Cycles of Cellular Proteins

Meytal Radzinski et al.

Summary: Protein homeostasis and redox regulation are closely connected, with redox-regulated proteins or thiol-based switches at the core. Research discusses the redox code of the proteostasis network and evolving strategies of antioxidant proteins under oxidative stress conditions. The importance of cysteine in protein degradation is also highlighted.

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COVID-19 in Relation to Hyperglycemia and Diabetes Mellitus

Hayder M. Al-kuraishy et al.

Summary: COVID-19 caused by SARS-CoV-2 may lead to extrapulmonary manifestations like diabetes mellitus and hyperglycemia, with SARS-CoV-2 infecting the pancreas through ACE2. The severity of SARS-CoV-2 infection in DM patients is associated with preexisting comorbidities and inflammation disorders. Some antidiabetic agents may reduce SARS-CoV-2 severity through modulation of the ACE2 receptor expression.

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Article Biochemistry & Molecular Biology

The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen Metabolism

Marianna Caterino et al.

Summary: The study conducted a mass spectrometry-based targeted metabolomic analysis on 52 hospitalized COVID-19 patients, revealing distinct changes in serum metabolites levels, particularly increased levels of lactic acid in all forms of the disease. Pathway analysis indicated dysregulation in energy production and amino acid metabolism. Overall, the variations in the serum metabolome of COVID-19 patients suggest a systemic perturbation induced by SARS-CoV-2, potentially affecting liver metabolism of carbon and nitrogen.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal Implications

Alessandra Stasi et al.

Summary: HDL not only participates in cholesterol transport, but also exhibits anti-inflammatory, anti-apoptotic, anti-thrombotic, and anti-infection properties. Changes in the amount and composition of HDL during sepsis lead to dysregulated host immune response and endothelial dysfunction. The multifaceted relationship between kidney dysfunction, dyslipidemia, and inflammation encourages further exploration of connecting mechanisms.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Medicine, General & Internal

Symptoms, complications and management of long COVID: a review

Olalekan Lee Aiyegbusi et al.

Summary: Patients with long COVID experience a wide range of physical and mental symptoms, with common issues including fatigue, shortness of breath, and headaches. Beyond symptoms and complications, they often report impaired quality of life, mental health issues, and employment problems.

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE (2021)

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Article Clinical Neurology

Skeletal Muscle and Peripheral Nerve Histopathology in COVID-19

Joome Suh et al.

Summary: In patients who died after SARS-CoV-2 infection, muscle and nerve tissues showed various pathological changes, predominantly indicating inflammatory/immune-mediated damage possibly related to cytokine release. There was no evidence of direct viral invasion of these tissues.

NEUROLOGY (2021)

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Article Multidisciplinary Sciences

Both high and low pre-infection glucose levels associated with increased risk for severe COVID-19: New insights from a population-based study

Michal Shauly-Aharonov et al.

Summary: This study indicates that elevated pre-infection blood glucose is a risk factor for severe COVID-19, even in non-diabetic individuals. For patients with diabetes, both high and low pre-infection glucose levels are risk factors for severe COVID-19. Further research is needed to determine if these associations are causal, but these findings can already have clinical implications for COVID-19 risk assessment and stratification.

PLOS ONE (2021)

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Article Microbiology

Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients

Jonathan Youngs et al.

Summary: The activation of MAIT cells in critically ill COVID-19 patients is a significant predictor of death and is associated with other mortality-associated immunologic measures. Additionally, a shift from focused IFN alpha-driven signals to broad pro-inflammatory responses in fatal COVID-19 patients was observed, which was not seen in severe influenza cases. The study identified key potential biomarkers and targetable pathways in critical viral illnesses, shared between influenza and COVID-19, with some unique to each infection.

PLOS PATHOGENS (2021)

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Article Clinical Neurology

Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died

Tom Aschman et al.

Summary: Patients who died with severe COVID-19 showed signs of myositis ranging from mild to severe, with skeletal muscle inflammation associated with the duration of illness and more pronounced than cardiac inflammation. Detection of viral load in muscles was low, suggesting a postinfectious, immune-mediated myopathy associated with SARS-CoV-2.

JAMA NEUROLOGY (2021)

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Article Gastroenterology & Hepatology

Low-Grade Endotoxemia and Thrombosis in COVID-19

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Summary: This study found that low-grade endotoxemia is detectable in patients with COVID-19 and is associated with thrombotic events. LPS and D-dimer can independently predict thrombotic events in COVID-19 patients.

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Article Immunology

Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism

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Summary: Transcriptomic changes in endothelial cells (ECs) infected by coronaviruses and stimulated by DAMPs lead to upregulation of innate immune regulatomic genes (IGs), contributing to various aspects including COVID-19, cardiovascular diseases, inflammation, transplantation, autoimmune diseases, and cancers. The activation of nucleic acid sensors and modulation of gene expression by various PAMPs and DAMPs play crucial roles in the immune response of ECs. The findings suggest a novel function of ECs in promoting myelopoiesis and trained immunity, which may drive cytokine storms and increase thromboembolic potential in COVID-19.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione

Desiree Bartolini et al.

Summary: This study found that SARS-CoV2 infection impairs cellular glutathione metabolism, leading to a decrease in GSH levels. Treatment with NAC and the antiviral drug Nel can prevent this defect.

REDOX BIOLOGY (2021)

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Review Endocrinology & Metabolism

Early and late endocrine complications of COVID-19

Paraskevi Kazakou et al.

Summary: The endocrine system plays a crucial role in maintaining human homeostasis, and understanding the potential effects of COVID-19 on endocrine glands is essential for prevention and management of endocrine disorders in infected patients. Research has shown a focus on the impact of COVID-19 infection on glucose dysregulation and new onset diabetes mellitus, with limited data available on the early and late complications of endocrine disorders during and after recovery from the infection. Long-term studies are needed to further evaluate the effects of COVID-19 on the endocrine glands.

ENDOCRINE CONNECTIONS (2021)

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Article Medicine, General & Internal

Serum Metabolic Profile in Patients With Long-Covid (PASC) Syndrome: Clinical Implications

Evasio Pasini et al.

Summary: Patients with long-Covid syndrome exhibit abnormalities in blood markers related to coagulation, protein disarrangement, and inflammation, indicating ongoing metabolic alterations contributing to the persistence of PASC. Long-term elevated D-Dimer levels suggest potential risks for thromboembolic disease.

FRONTIERS IN MEDICINE (2021)

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Article Multidisciplinary Sciences

In silico evaluation of the interaction between ACE2 and SARS-CoV-2 Spike protein in a hyperglycemic environment

Giovanni Sartore et al.

Summary: The study investigated the impact of non-enzymatic glycation on the interaction between human ACE2 receptor and SARS-CoV-2 Spike protein in a hyperglycemic environment. Results showed that glycation of lysine aminoacid residues reduced the number of interactions between ACE2 receptor and the Spike protein, potentially leading to alternative entry routes for the virus.

SCIENTIFIC REPORTS (2021)

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Article Gastroenterology & Hepatology

Impact of COVID-19 in Liver Disease Progression

Miguel Angel Martinez et al.

Summary: The novel coronavirus SARS-CoV-2 has caused the global COVID-19 pandemic in a short period of time, with implications for individuals with underlying chronic liver disease who may face increased risk of adverse outcomes and liver damage.

HEPATOLOGY COMMUNICATIONS (2021)

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Article Cell Biology

Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms

Eric Song et al.

Summary: The study revealed compartmentalized immune response in the central nervous system of individuals with COVID-19, suggesting a potential role of autoimmunity in the neurological sequelae of COVID-19.

CELL REPORTS MEDICINE (2021)

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Article Endocrinology & Metabolism

SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas

Janis A. Mueller et al.

Summary: The study shows that SARS-CoV-2 can infect and impact insulin secretion in human pancreatic cells, potentially contributing to metabolic dysregulation observed in COVID-19 patients.

NATURE METABOLISM (2021)

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Review Endocrinology & Metabolism

COVID-19 and diabetes mellitus: from pathophysiology to clinical management

Soo Lim et al.

Summary: Initial studies have shown that patients with diabetes mellitus have a higher risk of severe COVID-19, potentially due to hyperglycaemia affecting immune and inflammatory responses. Further investigation is needed to determine the optimal management for patients with diabetes mellitus during the ongoing pandemic.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Review Pharmacology & Pharmacy

Nitric oxide signalling in the brain and its control of bodily functions

Konstantina Chachlak et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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The crosstalk between hypoxia-inducible factor-1α and microRNAs in acute kidney injury

Zhiyu Wang et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

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Review Critical Care Medicine

ICU-acquired weakness

Ilse Vanhorebeek et al.

INTENSIVE CARE MEDICINE (2020)

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Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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A new coronavirus associated with human respiratory disease in China

Fan Wu et al.

NATURE (2020)

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Editorial Material Cardiac & Cardiovascular Systems

COVID-19 and the cardiovascular system

Ying-Ying Zheng et al.

NATURE REVIEWS CARDIOLOGY (2020)

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Clinical Characteristics of Coronavirus Disease 2019 in China

W. Guan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Microbiology

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

Michael Letko et al.

NATURE MICROBIOLOGY (2020)

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Editorial Material Biochemistry & Molecular Biology

SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection

Rafal Butowt et al.

ACS CHEMICAL NEUROSCIENCE (2020)

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Article Clinical Neurology

Steroid-Responsive Encephalitis in Coronavirus Disease 2019

Andrea Pilotto et al.

ANNALS OF NEUROLOGY (2020)

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Article Hematology

COVID-19 and its implications for thrombosis and anticoagulation

Jean M. Connors et al.

BLOOD (2020)

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Letter Cardiac & Cardiovascular Systems

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

Liang Chen et al.

CARDIOVASCULAR RESEARCH (2020)

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Letter Gastroenterology & Hepatology

ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection

Furong Liu et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Editorial Material Endocrinology & Metabolism

Management of diabetes today: An exciting confusion

Antonio Ceriello

DIABETES RESEARCH AND CLINICAL PRACTICE (2020)

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Letter Clinical Neurology

Two patients with acute meningoencephalitis concomitant with SARS-CoV-2 infection

R. Bernard-Valnet et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

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Article Gastroenterology & Hepatology

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

Tao Zuo et al.

GASTROENTEROLOGY (2020)

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Review Peripheral Vascular Disease

Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors-lessons from available evidence and insights into COVID-19

Hisashi Kai et al.

HYPERTENSION RESEARCH (2020)

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Review Pediatrics

A Review of Coronavirus Disease-2019 (COVID-19)

Tanu Singhal

INDIAN JOURNAL OF PEDIATRICS (2020)

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Musculoskeletal Consequences of COVID-19

Nathaniel P. Disser et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2020)

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SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19

Yijin Wang et al.

JOURNAL OF HEPATOLOGY (2020)

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Review Urology & Nephrology

High-Density Lipoproteins and Acute Kidney Injury

Loren E. Smith

SEMINARS IN NEPHROLOGY (2020)

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Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): A case series

Janice Wang et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Hematology

ISTH interim guidance on recognition and management of coagulopathy in COVID-19

Jecko Thachil et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Hematology

Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

Ning Tang et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Urology & Nephrology

Kidney disease is associated with in-hospital death of patients with COVID-19

Yichun Cheng et al.

KIDNEY INTERNATIONAL (2020)

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Article Urology & Nephrology

Acute kidney injury in patients hospitalized with COVID-19

Jamie S. Hirsch et al.

KIDNEY INTERNATIONAL (2020)

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Article Urology & Nephrology

Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China

Hua Su et al.

KIDNEY INTERNATIONAL (2020)

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Article Clinical Neurology

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

Ling Mao et al.

JAMA NEUROLOGY (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Article Infectious Diseases

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

Meng-Yuan Li et al.

INFECTIOUS DISEASES OF POVERTY (2020)

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Article Endocrinology & Metabolism

Hyponatremia, IL-6, and SARS-CoV-2 (COVID-19) infection: may all fit together?

A. Berni et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2020)

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Article Cardiac & Cardiovascular Systems

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

Shaobo Shi et al.

JAMA CARDIOLOGY (2020)

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Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

Denisa Bojkova et al.

NATURE (2020)

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Editorial Material Cell Biology

Roles and Functions of ROS and RNS in Cellular Physiology and Pathology

Neven Zarkovic

CELLS (2020)

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Letter Medicine, General & Internal

Neurologic Features in Severe SARS-CoV-2 Infection

Julie Helms et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19

Muthiah Vaduganathan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Editorial Material Clinical Neurology

Guillain-Barre syndrome related to COVID-19 infection

Paola Alberti et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2020)

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Review Biochemistry & Molecular Biology

Oxidants, Antioxidants and Thiol Redox Switches in the Control of Regulated Cell Death Pathways

Moran Benhar

ANTIOXIDANTS (2020)

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Bioinformatics studies on a function of the SARS-CoV-2 spike glycoprotein as the binding of host sialic acid glycans

B. Robson

COMPUTERS IN BIOLOGY AND MEDICINE (2020)

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Diabetes and COVID-19: A systematic review on the current evidences

Alireza Abdi et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2020)

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Article Endocrinology & Metabolism

Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective study

Sufei Wang et al.

DIABETOLOGIA (2020)

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Review Medicine, General & Internal

COVID-19 and non-alcoholic fatty liver disease: Two intersecting pandemics

Piero Portincasa et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Gastroenterology & Hepatology

Coronavirus disease (COVID-19) and the liver: a comprehensive systematic review and meta-analysis

Praveen Kumar-M et al.

HEPATOLOGY INTERNATIONAL (2020)

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Article Cell Biology

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

Ana Campos Codo et al.

CELL METABOLISM (2020)

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Article Cell & Tissue Engineering

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Liuliu Yang et al.

CELL STEM CELL (2020)

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Article Infectious Diseases

Urgent need for evaluating agonists of angiotensin-(1-7)/Mas receptor axis for treating patients with COVID-19

Ashwini Shete

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Review Clinical Neurology

Neurological and Musculoskeletal Features of COVID-19: A Systematic Review and Meta-Analysis

Auwal Abdullahi et al.

FRONTIERS IN NEUROLOGY (2020)

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Article Physiology

The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies

Peter J. Ferrandi et al.

JOURNAL OF APPLIED PHYSIOLOGY (2020)

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Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

David H. Brann et al.

SCIENCE ADVANCES (2020)

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Review Immunology

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

Bingwen Liu et al.

JOURNAL OF AUTOIMMUNITY (2020)

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Article Medicine, Research & Experimental

Clinical and pathological investigation of patients with severe COVID-19

Shaohua Li et al.

JCI INSIGHT (2020)

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Elevation of blood glucose level predicts worse outcomes in hospitalized patients with COVID-19: a retrospective cohort study

Jianfeng Wu et al.

BMJ OPEN DIABETES RESEARCH & CARE (2020)

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COVID-19 Clinical Characteristics, and Sex-Specific Risk of Mortality: Systematic Review and Meta-Analysis

Mohammad Javad Nasiri et al.

FRONTIERS IN MEDICINE (2020)

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Review Gastroenterology & Hepatology

COVID-19 and the liver

Dinesh Jothimani et al.

JOURNAL OF HEPATOLOGY (2020)

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Letter Clinical Neurology

Association of neuronal injury blood marker neurofilament light chain with mild-to-moderate COVID-19

Markus Ameres et al.

JOURNAL OF NEUROLOGY (2020)

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Article Urology & Nephrology

COVID-19-Associated Kidney Injury: A Case Series of Kidney Biopsy Findings

Purva Sharma et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

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Article Medicine, General & Internal

Targeting TMPRSS2 in SARS-CoV-2 Infection

Linda B. Baughn et al.

MAYO CLINIC PROCEEDINGS (2020)

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Review Biochemistry & Molecular Biology

Effects of COVID-19 on the Nervous System

Costantino Iadecola et al.

CELL (2020)

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Longitudinal analyses reveal immunological misfiring in severe COVID-19

Carolina Lucas et al.

NATURE (2020)

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Article Clinical Neurology

Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19

Nelly Kanberg et al.

NEUROLOGY (2020)

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Article Medicine, General & Internal

New-Onset Diabetes in Covid-19

Francesco Rubino et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Medicine, General & Internal

COVID-19 and the kidney

Mohamed Hassanein et al.

CLEVELAND CLINIC JOURNAL OF MEDICINE (2020)

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Article Endocrinology & Metabolism

Hyperglycemia and COVID-19: What was known and what is really new?

Antonio Ceriello

DIABETES RESEARCH AND CLINICAL PRACTICE (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Retrospective Observational Study of Brain MRI Findings in Patients with Acute SARS-CoV-2 Infection and Neurologic Manifestations

Lydia Chougar et al.

RADIOLOGY (2020)

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Article Clinical Neurology

COVID-19-related encephalopathy: a case series with brain FDG-positron-emission tomography/computed tomography findings

C. Delorme et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

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Review Biochemistry & Molecular Biology

SARS-CoV-2/Renin-Angiotensin System: Deciphering the Clues for a Couple with Potentially Harmful Effects on Skeletal Muscle

Andrea Gonzalez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Letter Medicine, General & Internal

SARS-CoV-2 renal tropism associates with acute kidney injury

Fabian Braun et al.

LANCET (2020)

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Article Oncology

COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study

Lennard Y. W. Lee et al.

LANCET ONCOLOGY (2020)

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The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach

Gerwyn Morris et al.

LIFE SCIENCES (2020)

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Mitochondria and microbiota dysfunction in COVID-19 pathogenesis

Jumana Saleh et al.

MITOCHONDRION (2020)

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Neuropilin-1 is a host factor for SARS-CoV-2 infection

James L. Daly et al.

SCIENCE (2020)

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Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Ludovico Cantuti-Castelvetri et al.

SCIENCE (2020)

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The Inflammasome in Times of COVID-19

Juan Carlos de Rivero Vaccari et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Role of Renin-Angiotensin System in Acute Lung Injury Caused by Viral Infection

Yan-Lei Gao et al.

INFECTION AND DRUG RESISTANCE (2020)

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SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum

Chiara Bruzzone et al.

ISCIENCE (2020)

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COVID-19 and Oxidative Stress

B. Chernyak et al.

BIOCHEMISTRY-MOSCOW (2020)

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SARS-CoV-2 and Other Respiratory Viruses: What Does Oxidative Stress Have to Do with It?

Iara Grigoletto Fernandes et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches

Yuefei Jin et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Endocrinology & Metabolism

Interactions between antihyperglycemic drugs and the reninangiotensin system: Putative roles in COVID-19. A mini-review

Afif Nakhleh et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

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Article Multidisciplinary Sciences

Liver injury with COVID-19 based on gastrointestinal symptoms and pneumonia severity

Shun Kaneko et al.

PLOS ONE (2020)

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Article Clinical Neurology

Dyspneic and non-dyspneic (silent) hypoxemia in COVID-19: Possible neurological mechanism

Masoud Nouri-Vaskeh et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2020)

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Article Medicine, Research & Experimental

Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients

Ashutosh Kumar et al.

MEDICAL HYPOTHESES (2020)

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Article Endocrinology & Metabolism

Fasting blood glucose level is a predictor of mortality in patients with COVID-19 independent of diabetes history

Yuli Cai et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2020)

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Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review

Shanzay Suhail et al.

PROTEIN JOURNAL (2020)

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Letter Immunology

Rhabdomyolysis as Potential Late Complication Associated with COVID-19

Min Jin et al.

EMERGING INFECTIOUS DISEASES (2020)

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Glycemic Characteristics and Clinical Outcomes of COVID-19 Patients Hospitalized in the United States

Bruce Bode et al.

JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY (2020)

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Letter Endocrinology & Metabolism

Acute Hyperglycemic Crises with Coronavirus Disease-19: Case Reports (Diabetes Metab J 2020;44: 349-53)

Na-Young Kim et al.

DIABETES & METABOLISM JOURNAL (2020)

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Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Endocrinology & Metabolism

Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report

Tim Hollstein et al.

NATURE METABOLISM (2020)

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Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair

Shaoqun Shu et al.

CELLS (2019)

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Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses

Maria Maximina B. Moreno-Altamirano et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

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Viral hijacking of cellular metabolism

Shivani K. Thaker et al.

BMC BIOLOGY (2019)

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The Emerging Role of Neutrophil Extracellular Traps in Respiratory Disease

Scott H. Twaddell et al.

CHEST (2019)

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The Chenging Clinical Spectrum of Hypophysitis

Sabrina Chiloiro et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

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Cerebellar Hypermetabolism in Alcohol Use Disorder: Compensatory Mechanism or Maladaptive Plasticity?

Ludivine Ritz et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2019)

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Kidney-Immune System Crosstalk in AKI

Kai Singbartl et al.

SEMINARS IN NEPHROLOGY (2019)

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Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication

Bingpeng Yan et al.

VIRUSES-BASEL (2019)

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The Renin-Angiotensin System and Skeletal Muscle

Scott K. Powers et al.

EXERCISE AND SPORT SCIENCES REVIEWS (2018)

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ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications

N. T. Moldogazieva et al.

FREE RADICAL RESEARCH (2018)

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Modulation of the renin-angiotensin system in white adipose tissue and skeletal muscle: focus on exercise training

Eliete Dalla Corte Frantz et al.

CLINICAL SCIENCE (2018)

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Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections

Zhenguang Li et al.

ARCHIVES OF VIROLOGY (2017)

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Implications of oxidative stress on viral pathogenesis

Fernanda Caetano Camini et al.

ARCHIVES OF VIROLOGY (2017)

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2-18F-fluoro-2-deoxyglucose positron emission tomography in delirium

Lucy R. Haggstrom et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

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Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

Rudragouda Channappanavar et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

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Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update

Hua Su et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

Helmut Sies

REDOX BIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Mitochondria-meditated pathways of organ failure upon inflammation

Andrey V. Kozlov et al.

REDOX BIOLOGY (2017)

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Review of Critical Illness Myopathy and Neuropathy

Starane Shepherd et al.

NEUROHOSPITALIST (2017)

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Molecular mechanisms regulating NLRP3 inflammasome activation

Eun-Kyeong Jo et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2016)

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Mechanisms and mediators of lung injury after acute kidney injury

Sarah Faubel et al.

NATURE REVIEWS NEPHROLOGY (2016)

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Acute Kidney Injury

Anna Zuk et al.

ANNUAL REVIEW OF MEDICINE, VOL 67 (2016)

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Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus

Panai Song et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2016)

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Physical declines occurring after hospital discharge in ARDS survivors: a 5-year longitudinal study

Elizabeth R. Pfoh et al.

INTENSIVE CARE MEDICINE (2016)

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Redox signaling regulated by electrophiles and reactive sulfur species

Motohiro Nishida et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2016)

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Neutrophil extracellular Traps in Pulmonary Diseases: Too Much of a Good Thing?

Barbara Nery Porto et al.

FRONTIERS IN IMMUNOLOGY (2016)

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The Redox Code

Dean P. Jones et al.

ANTIOXIDANTS & REDOX SIGNALING (2015)

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Renin-Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle

Claudio Cabello-Verrugio et al.

MEDICINAL RESEARCH REVIEWS (2015)

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Mitochondrial DNA stress primes the antiviral innate immune response

A. Phillip West et al.

NATURE (2015)

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Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy

P. Rocheteau et al.

NATURE COMMUNICATIONS (2015)

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Receptor Recognition Mechanisms of Coronaviruses: a Decade of Structural Studies

Fang Li

JOURNAL OF VIROLOGY (2015)

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Adenovirus E4ORF1-Induced MYC Activation Promotes Host Cell Anabolic Glucose Metabolism and Virus Replication

Minh Thai et al.

CELL METABOLISM (2014)

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Brain Normal Variations and Benign Findings in Fluorodeoxyglucose-PET/Computed Tomography Imaging

Valentina Berti et al.

PET CLINICS (2014)

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Redox Signaling by 8-Nitro-cyclic Guanosine Monophosphate: Nitric Oxide-and Reactive Oxygen Species-Derived Electrophilic Messenger

Shigemoto Fujii et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

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Review Oncology

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

Xinyuan Li et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2013)

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ACE2 alterations in kidney disease

Maria Jose Soler et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2013)

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Angiotensin II-Induced Mitochondrial Nox4 Is a Major Endogenous Source of Oxidative Stress in Kidney Tubular Cells

Su-Mi Kim et al.

PLOS ONE (2012)

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Pathophysiology of Acute Kidney Injury

David P. Basile et al.

COMPREHENSIVE PHYSIOLOGY (2012)

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Mitochondrial reactive oxygen species drive proinflammatory cytokine production

Edwina Naik et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

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Article Immunology

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Kiichi Nakahira et al.

NATURE IMMUNOLOGY (2011)

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Divergent Effects of Human Cytomegalovirus and Herpes Simplex Virus-1 on Cellular Metabolism

Livia Vastag et al.

PLOS PATHOGENS (2011)

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Dengue Virus-Induced Autophagy Regulates Lipid Metabolism

Nicholas S. Heaton et al.

CELL HOST & MICROBE (2010)

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Review Physiology

Acute kidney injury: a springboard for progression in chronic kidney disease

Manjeri A. Venkatachalam et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)

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Review Medicine, General & Internal

Stress hyperglycaemia

Kathleen M. Dungan et al.

LANCET (2009)

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Review Physiology

The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice

Yumiko Imai et al.

EXPERIMENTAL PHYSIOLOGY (2008)

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Article Urology & Nephrology

Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury

Peter Hill et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)

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Article Physiology

Effect of renal lipid accumulation on proximal tubule Na+/H+ exchange and ammonium secretion

I. Alexandru Bobulescu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2008)

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Review Biochemistry & Molecular Biology

Cell entry by enveloped viruses: Redox considerations for HIV and SARS-coronavirus

Emmanuel Fenouillet et al.

ANTIOXIDANTS & REDOX SIGNALING (2007)

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Article Cell Biology

Migration of leukocytes across an endothelium-epithelium bilayer as a model of renal interstitial inflammation

Klaudija Bijuklic et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)

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Article Biochemistry & Molecular Biology

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

Ryo Fukuda et al.

CELL (2007)

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Article Urology & Nephrology

Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury

Thomas S. Hoke et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)

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Article Urology & Nephrology

Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: Implications for albuminuria in diabetes

Minghao Ye et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)

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Article Biochemistry & Molecular Biology

Significant redox insensitivity of the functions of the SARS-CoV spike glycoprotein - Comparison with HIV envelope

D Lavillette et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Clinical Neurology

Cerebellar hypermetabolism in paraneoplastic cerebellar degeneration

KD Choi et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2006)

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Article Urology & Nephrology

Ischemic acute renal failure: An inflammatory disease?

JV Bonventre et al.

KIDNEY INTERNATIONAL (2004)

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Review Biochemistry & Molecular Biology

Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host

W Khovidhunkit et al.

JOURNAL OF LIPID RESEARCH (2004)

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Article Endocrinology & Metabolism

Quantifying the risk of infectious diseases for people with diabetes

BR Shah et al.

DIABETES CARE (2003)

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