Journal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2022.974259
Keywords
severe burn; gut microbiome; intestinal mucosal barrier; microbial therapy; dysbiosis
Categories
Funding
- Natural Science Foundation of Guangdong Province
- Medical Science and Technology Research Fund Project of Guangdong Province
- [2019A1515010408]
- [A2018444]
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Severe burn can lead to serious complications globally, with changes in the gut microbiome playing a significant role in pathogenesis. Dysbiosis and damage to the intestinal mucosal barrier post-burn can lead to bacterial translocation and subsequent complications. Modulating the microbiota composition may improve intestinal diseases and provide new directions for post-burn treatment.
Severe burn is a serious acute trauma that can lead to significant complications such as sepsis, multiple organ failure, and high mortality worldwide. The gut microbiome, the largest microbial reservoir in the human body, plays a significant role in this pathogenic process. Intestinal dysbiosis and disruption of the intestinal mucosal barrier are common after severe burn, leading to bacterial translocation to the bloodstream and other organs of the body, which is associated with many subsequent severe complications. The progression of some intestinal diseases can be improved by modulating the composition of gut microbiota and the levels of its metabolites, which also provides a promising direction for post-burn treatment. In this article, we summarised the studies describing changes in the gut microbiome after severe burn, as well as changes in the function of the intestinal mucosal barrier. Additionally, we presented the potential and challenges of microbial therapy, which may provide microbial therapy strategies for severe burn.
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