4.8 Article

Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Release of CHK-2 from PPM-1.D anchorage schedules meiotic entry

Antoine Baudrimont et al.

Summary: In this study, the phosphatase PPM-1.D/Wip1 is identified as a crucial substrate for PROM-1, and it regulates the initiation of meiotic prophase I by antagonizing CHK-2 kinase. PPM-1.D controls the amount of active CHK-2 through both catalytic and noncatalytic activities.

SCIENCE ADVANCES (2022)

Article Biology

Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity

Heyun Guo et al.

Summary: In the nematode Caenorhabditis elegans, the level of double-strand breaks (DSBs) during meiotic cell division is regulated by the phosphorylation of DSB-1. The phosphorylation of DSB-1 is controlled by the opposing activities of the PP4 phosphatase and the ATR kinase. The loss of DSB-2, a paralog of DSB-1, leads to a decrease in DSB formation. The results suggest that DSB-1 phosphorylation is compensated by DSB-2 in order to maintain optimal levels of DSBs in older animals.

ELIFE (2022)

Review Cell Biology

Phospho-Regulation of Meiotic Prophase

Funda M. Kar et al.

Summary: Germ cells rely on a complex network of surveillance mechanisms to ensure the production of euploid gametes during meiosis. Dynamic protein phosphorylation, controlled by kinases and phosphatases, plays a crucial role in regulating chromosomal and cellular behavior throughout meiotic prophase. This review discusses common principles and detailed examples of how phosphorylation events are utilized to ensure faithful passage of chromosomes from one generation to the next.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Genetics & Heredity

Architecture and Dynamics of Meiotic Chromosomes

Sarah N. Ur et al.

Summary: Meiotic cell division is a specialized process preparing for sexual reproduction, involving homologous chromosomes identifying each other and forming physical links through DNA recombination. The SMC family cohesin complexes and meiotic chromosome axis play crucial roles in organizing chromosomes and promoting recombination. The synaptonemal complex (SC) ensures high fidelity in meiotic recombination by assembling between homologs and providing feedback.

ANNUAL REVIEW OF GENETICS, VOL 55 (2021)

Article Biochemistry & Molecular Biology

The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation

Min-Su Lee et al.

Summary: The Ecm11-Gmc2 (EG) complex plays a critical role in meiotic recombination in yeast by regulating double-strand break formation and crossover frequencies, while the SC central region is essential for controlling specificity during meiosis recombination.

NUCLEIC ACIDS RESEARCH (2021)

Article Multidisciplinary Sciences

Multilayered mechanisms ensure that short chromosomes recombine in meiosis

Hajime Murakami et al.

NATURE (2020)

Article Cell Biology

Spatial and temporal control of targeting Polo-like kinase during meiotic prophase

James N. Brandt et al.

JOURNAL OF CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Surveillance of cohesin-supported chromosome structure controls meiotic progression

Maikel Castellano-Pozo et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Crossing and zipping: molecular duties of the ZMM proteins in meiosis

Alexandra Pyatnitskaya et al.

CHROMOSOMA (2019)

Review Cell Biology

Meiotic recombination and the crossover assurance checkpoint in Caenorhabditis elegans

Zhouliang Yu et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2016)

Article Biochemical Research Methods

IBS: an illustrator for the presentation and visualization of biological sequences

Wenzhong Liu et al.

BIOINFORMATICS (2015)

Article Cell Biology

Meiotic Recombination: The Essence of Heredity

Neil Hunter

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Article Multidisciplinary Sciences

Homologue engagement controls meiotic DNA break number and distribution

Drew Thacker et al.

NATURE (2014)

Article Cell Biology

The Meiotic Checkpoint Network: Step-by-Step through Meiotic Prophase

Vijayalakshmi V. Subramanian et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

Article Cell Biology

Conservation of mRNA and Protein Expression during Development of C.elegans

Dominic Gruen et al.

CELL REPORTS (2014)

Article Cell Biology

Numerical constraints and feedback control of double-strand breaks in mouse meiosis

Liisa Kauppi et al.

GENES & DEVELOPMENT (2013)

Article Genetics & Heredity

Crossover Distribution and Frequency Are Regulated by him-5 in Caenorhabditis elegans

Philip M. Meneely et al.

GENETICS (2012)

Article Biochemical Research Methods

The Plk1-dependent Phosphoproteome of the Early Mitotic Spindle

Anna Santamaria et al.

MOLECULAR & CELLULAR PROTEOMICS (2011)

Article Biochemistry & Molecular Biology

Meiotic Chromosome Homology Search Involves Modifications of the Nuclear Envelope Protein Matefin/SUN-1

Alexandra M. Penkner et al.

Article Biochemical Research Methods

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

Kohei Nishimura et al.

NATURE METHODS (2009)

Article Biochemistry & Molecular Biology

Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis

Hengyao Niu et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

Antony W. Oliver et al.

EMBO JOURNAL (2006)

Article Biochemistry & Molecular Biology

Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach

T O'Neill et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination

I Oishi et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

T-Coffee: A novel method for fast and accurate multiple sequence alignment

C Notredame et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)