Visible-Light-Promoted Electron Donor-Acceptor Complex Enabled Decarboxylative Alkylation of Quinoxalin-2(1H)-ones and N-Hydroxyphthalimide Esters with Na2S as a Catalytic Donor

We developed a novel and efficient method for the synthesis of various 3-alkylated quinoxalin-2(1H)-ones (32 examples, 70%-96% yields) through electron donor-acceptor complex enabled alkylation of quinoxalin-2(1H)-ones with N- hydroxyphthalimide esters as the alkyl source and Na2S as the catalytic electron donor under external photocatalyst-, oxidant- and additive-free conditions.

Automated summary

We developed a novel and efficient method for the synthesis of various 3-alkylated quinoxalin-2(1H)-ones through an electron donor-acceptor complex enabled alkylation. This method utilized N-hydroxyphthalimide esters as the alkyl source and Na2S as the catalytic electron donor, achieving high yields (70%-96%) under photocatalyst-, oxidant-, and additive-free conditions.