Comparative efficacy of cephradine-loaded silver and gold nanoparticles against resistant human pathogens

Infections caused by drug-resistant bacteria are major health concerns worldwide. We successfully synthesized cephradine gold nanoparticles (Ceph-Au NPs) and cephradine silver nanoparticles (Ceph-Ag NPs) and compared their efficacy against resistant human pathogens. X-Ray diffraction (XRD), Atomic Force Microscopy (AFM) and Transmission Electron Microscopy (TEM) results showed that average particle size of Ceph-Au NPs and Ceph-Ag NPs were 7 and 12 nm, respectively. Fourier Transform Infra-red spectroscopy (FTIR) spectra revealed the conjugation of -NH2 and -OH functional moieties with the nanoparticle (NP) surfaces. These NPs significantly inhibited the biofilm of Streptococcus mutans (S. mutans) and methicillin-resistant Staphylococcus aureus (MRSA) in the range of 61.25-250 mu g/mL. Ceph-Au NPs are more active than Ceph-Ag NPs and can be used to treat the diseases associated with MRSA and S. mutans.

Automated summary

The study successfully synthesized cephradine gold nanoparticles and cephradine silver nanoparticles, with gold nanoparticles showing more activity against methicillin-resistant Staphylococcus aureus and Streptococcus mutans. These nanoparticles have the potential to be used in the treatment of diseases associated with MRSA and S. mutans.