Journal
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
Volume 31, Issue 2, Pages 107-112Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PAI.0000000000001096
Keywords
mucin; MUC; ulcerative colitis; crohn disease; ischemic colitis; inflammatory bowel disease; immunohistochemistry
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By studying intestinal samples from patients with ulcerative colitis (UC) and Crohn disease (CD), it was found that MUC1 was expressed more in the UC group and MUC6 was expressed more in the CD group. These changes in MUC expression can aid in the diagnosis and early clinical management of UC and CD.
Ulcerative colitis (UC) and Crohn disease (CD) are cryptogenic inflammatory bowel diseases that are suggestive of aberrant mucin (MUC) expression; however, their relationship remains unclear. Here, we examined aberrant MUC expression in intestinal samples from UC and CD patients in comparison to samples from patients with ischemic colitis and control groups. To study the expression of MUC1, MUC5AC, and MUC6 in different patient groups, we reviewed the slides stained with hematoxylin and eosin and performed immunohistochemistry. The results revealed that MUC1 was expressed more in the UC group and MUC6 in the CD group. No significant changes were observed in MUC expression in the ischemic colitis group. Overall, we demonstrated changes in MUC expression in UC and CD, which can help in the diagnosis and early clinical management of UC and CD.
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