Voice Tremor and Botulinum Neurotoxin Therapy: A Contemporary Review

Voice tremor is a common, yet debilitating symptom for patients suffering from a number of tremor-associated disorders. The key to targeting effective treatments for voice tremor requires a fundamental understanding of the pathophysiology that underpins the tremor mechanism and accurate identification of the disease in affected patients. An updated review of the literature detailing the current understanding of voice tremor (with or without essential tremor), its accurate diagnosis and targeted treatment options was conducted, with a specific focus on the role of botulinum neurotoxin. Judicious patient selection, following detailed characterisation of voice tremor qualities, is essential to optimising treatment outcomes for botulinum neurotoxin therapy, as well as other targeted therapies. Further focused investigation is required to characterise the response to targeted treatment in voice tremor patients and to guide the development of innovative treatment options.

Automated summary

Voice tremor is a common symptom for patients with tremor-associated disorders, and understanding its pathophysiology and accurate diagnosis are crucial for effective treatment. This review provides an updated understanding of voice tremor and the role of botulinum neurotoxin, emphasizing the importance of detailed patient characterization and further research on targeted treatment options.