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CHINESE CHEMICAL LETTERS
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CHINESE CHEMICAL LETTERS
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Pharmacology & Pharmacy
Jaskiran Kaur et al.
Summary: Polymeric micelles (PMs) are unique carriers for targeted delivery and enhancement of the bioavailability of chemotherapeutics. They have the potential to encapsulate multiple therapeutic molecules and can be used for drug therapy and tumor imaging. However, there are some limitations associated with the translation of PMs from the laboratory to clinics.
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Damian M. Bailey et al.
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Yuanyuan Li et al.
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Sabina Quader et al.
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Jie Bai et al.
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Xiangle Zeng et al.
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Wang Yin et al.
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Hongyu Long et al.
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Pharmacology & Pharmacy
Anisha Mazumder et al.
Summary: In this study, galactose-targeted and non-targeted micelles were designed to enhance the anticancer activity and achieve targeted imaging using RSPP050 as an anticancer agent and superparamagnetic iron oxide (SPIO) as a contrast agent. The results showed that galactose micelles had higher drug loading content and cytotoxicity compared to non-targeted micelles. Moreover, targeted SPIO micelles decreased the magnetic resonance imaging (MRI) intensity, indicating their potential as a contrast agent for hepatocellular carcinoma.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
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Chemistry, Multidisciplinary
Vahideh Mohammadzadeh et al.
Summary: Plants contain compounds that can be used to generate nanomaterials in a safe way, which have diverse applications in the treatment of various diseases. Nano-materials derived from plant extracts have promising biomedical applications.
SUSTAINABLE CHEMISTRY AND PHARMACY
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Nanoscience & Nanotechnology
Lexin Liu et al.
Summary: This study fabricated hydrophobic-hydrophilic patterns on a polyester-spandex-blended knitted fabric surface using the chemical click method for accurate deposition of functionalized materials. By deliberately depositing a conductive silver nanowire network on the designated hydrophilic fabric surface, accurate, repeatable, and stable motion sensing was achieved. The sensors exhibited high sensitivity to humidity and were able to detect real human motions, showing promising application potential in healthcare monitoring.
ACS APPLIED MATERIALS & INTERFACES
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Biophysics
Runliang Feng et al.
Summary: In this study, PBA-modified nano-polymer micelles were synthesized for doxorubicin encapsulation and their effects on drug release, tumor targeting, and antitumor activity were investigated. The results showed that the formulation had acid-sensitive drug release behavior, and a higher polymer dosage improved tumor targeting and antitumor activity.
COLLOIDS AND SURFACES B-BIOINTERFACES
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Xiaowei Wang et al.
Summary: This study investigated the use of a biodegradable hybrid micelles nano system for the co-delivery of paclitaxel (PTX) and IR825 in the treatment of malignant tumors. The results showed that the hybrid micelles successfully encapsulated PTX and improved the stability of IR825. In vitro cell analysis demonstrated effective internalization of the PTX/IR825-TAT HMs by breast cancer cells, and synergistic induction of apoptosis and death under laser irradiation. In vivo studies showed that PTX/IR825-TAT HMs precisely targeted tumor tissue and exhibited excellent synergistic antitumor efficiency compared to single chemotherapy and photothermal therapy.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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Sonia Lopez et al.
Summary: In this study, novel polymer-drug conjugates were synthesized and characterized. These conjugates, consisting of hydrophilic poly(ethylene glycol) (PEG) and privileged scaffolds with anticancer properties, were able to self-assemble into micelles and load other anticancer drugs. The sustained and controlled drug release profiles observed for paclitaxel and curcumin in the conjugates demonstrated the stability and potential of these conjugates as co-delivery carriers for synergistic cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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Haimei Cao et al.
Summary: Smart multifunctional polymeric micelles loaded with folate and pH-responsive cell membrane mimetic were successfully prepared, and the micelles exhibited excellent drug release properties and anti-tumor activity. These micelles have the potential to be applied in tumor therapy.
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Madhu Gupta et al.
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Ru Zhou et al.
Summary: By synthesizing a reduction-sensitive camptothecin derivative and modifying it with PEG, nanoparticles with tumor-targeting properties were prepared. The results demonstrated that these nanoparticles showed better targeting to tumor cells, accumulated more intracellularly, and prolonged retention time in vivo efficiently.
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Pharmacology & Pharmacy
Puze Li et al.
Summary: Nanomedicines have promising prospects in cancer treatment, but their in vivo delivery still faces challenges. In order to effectively treat tumors, nanomedicines need to meet the five principles of long blood circulation, efficient tumor accumulation, deep matrix penetration, enhanced cell internalization, and accurate drug release, and real-time imaging is essential for monitoring the drug delivery process and therapeutic effects.
ADVANCED DRUG DELIVERY REVIEWS
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Biochemistry & Molecular Biology
Margarida S. Miranda et al.
Summary: Hybrid nanoarchitectures such as magnetic polymeric micelles (MPMs) are highly promising nanotechnology-enabled materials that combine the advantages of polymeric micelles and magnetic nanoparticles in biomedical applications. MPMs can serve as contrast agents for magnetic resonance imaging (MRI), heat generators in hyperthermia treatments, and magnetic-susceptible nanocarriers for drug delivery and release. The versatility of MPMs makes them powerful vehicles for ultrasensitive, precise, and multifunctional diagnostic and therapeutic purposes. They have the potential to be applied in unexpected fields such as bioengineering and regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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Zahra Ansarinik et al.
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