Prospects on Tuning Bioactive and Antimicrobial Denture Base Resin Materials: A Narrative Review

Denture base resin (DBR) materials are used in dentistry in constructing removable dentures and implant-supported prostheses. A plethora of evidence has demonstrated that DBR materials are associated with a high risk of denture stomatitis, a clinical complication where the soft oral tissues underneath the resin-based material are inflamed. The prevalence of denture stomatitis among denture wearers is high worldwide. Plaque accumulation and the infiltration of oral microbes into DBRs are among the main risk factors for denture stomatitis. The attachment of fungal species, mainly Candida albicans, to DBRs can irritate the underneath soft tissues, leading to the onset of the disease. As a result, several attempts were achieved to functionalize antimicrobial compounds and particles into DBRs to prevent microbial attachment. This review article explored the advanced approaches in designing bioactive and antimicrobial DBR materials. It was reported that using monomer mixtures, quaternary ammonium compounds (QACs), and organic and inorganic particles can suppress the growth of denture stomatitis-related pathogens. This paper also highlighted the importance of characterizing bioactive DBRs to be mechanically and physically sustainable. Future directions may implement a clinical translational model to attempt these materials inside the oral cavity.

Automated summary

DBR materials used in dentistry for constructing dentures and prostheses pose a high risk of denture stomatitis, causing inflammation of soft oral tissues. Fungal attachment, mainly by Candida albicans, to DBRs is a major cause of the disease. Attempts have been made to incorporate antimicrobial compounds and particles into DBRs to prevent microbial attachment. This review explores advanced approaches to designing bioactive and antimicrobial DBR materials, emphasizing the importance of mechanical and physical sustainability.