Stereospecific/stereoselective nickel catalyzed reductive cross-coupling: An efficient tool for the synthesis of biological active targeted molecules

Reductive cross-electrophile transformations have recently been made into a robust and long-lasting synthetic technique for the production of specific CAC bonds. The use of inexpensive and plentiful electrophiles eliminates the need for pre-formation and handling of organometallics. In stereospecific reductive cross-coupling, nickel is one of the most cost-effective and flexible tran-sition metals. This paper examines current developments in nickel catalyzed reductive cross -coupling reactions and their potential application for the synthesis of biologically active molecules over the previous nine years.(c) 2022 Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

Reductive cross-electrophile transformations have become a reliable and durable synthetic technique for specific CAC bond production. The use of inexpensive and abundant electrophiles eliminates the need for organometallic pre-formation and handling. Nickel is a cost-effective and versatile transition metal widely used in stereospecific reductive cross-coupling reactions. This paper reviews the current advancements in nickel catalyzed reductive cross-coupling reactions and their potential application in the synthesis of biologically active molecules.