Journal
CELL REPORTS
Volume 41, Issue 13, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2022.111891
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Funding
- Program of the National Natural Science Foundation of China [81830100, 2018YFC1004202]
- National Key Project of Research and Development Program [2021YFC2701100, 2021YFC2701102, 81902836, 2018YFC1004200]
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In this study, the authors investigated the development and maturation of the heart by analyzing the phosphoproteome, proteome, metabolome, and transcriptome of mice hearts. They identified mitogen-activated protein kinases as core kinases involved in transcriptional regulation during early cardiogenesis. Furthermore, they discovered a network of transcription factors controlling early cardiogenesis, as well as cardiac resident macrophages clearing injured cardiomyocytes after birth. This comprehensive multi-omics data provides valuable insights into cardiac development and maturation.
Cardiogenesis is a tightly regulated dynamic process through a continuum of differentiation and proliferation events. Key factors and pathways governing this process remain incompletely understood. Here, we investigate mice hearts from embryonic day 10.5 to postnatal week 8 and dissect developmental changes in phosphoproteome-, proteome-, metabolome-, and transcriptome-encompassing cardiogenesis and cardiac maturation. We identify mitogen-activated protein kinases as core kinases involved in transcriptional regulation by mediating the phosphorylation of chromatin remodeling proteins during early cardiogenesis. We construct the reciprocal regulatory network of transcription factors (TFs) and identify a series of TFs controlling early cardiogenesis involved in cycling-dependent proliferation. After birth, we identify cardiac resident macrophages with high arachidonic acid metabolism activities likely involved in the clearance of injured apoptotic cardiomyocytes. Together, our comprehensive multi-omics data offer a panoramic view of cardiac development and maturation that provides a resource for further in-depth functional exploration.
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