Facilitating participation in clinical trials during pregnancy

Article Health Care Sciences & Services

Identification of the ideal recruitment situation in pandemic research: learning from the RECOVERY trial in Northern England: a qualitative study

Dorothy Coe et al.

Summary: This study aimed to investigate the factors affecting recruitment to the RECOVERY trial. The results revealed that embedding recruitment into standard care was the most influential factor, but there were inconsistencies in its implementation across different sites.

BMJ LEADER (2023)

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Article Obstetrics & Gynecology

Management and implications of severe COVID-19 in pregnancy in the UK: data from the UK Obstetric Surveillance System national cohort

Nicola Vousden et al.

Summary: Severe COVID-19 in pregnancy increases the risk of adverse outcomes. Factors such as age, overweight or obesity, mixed ethnicity, and gestational diabetes are associated with severe infection. Cesarean birth, preterm birth, stillbirth, and neonatal unit admission are more likely to occur in women with severe infection. Most women with severe infection who gave birth at a later admission delivered at 36 weeks or later, but rapid delivery may be warranted for those with severe infection at term.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2022)

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Article Immunology

Understanding COVID-19 vaccine uptake during pregnancy: 'Hesitance', knowledge, and evidence-based decision-making

Leigh Ann Simmons et al.

Summary: This study surveyed pregnant individuals in California to explore their attitudes and decision-making regarding COVID-19 vaccination. The majority of participants were aware of the vaccines, but 57% reported hesitancy towards vaccination. Factors such as younger age, living in less urban areas, and being an essential worker were associated with vaccine hesitancy. Lack of knowledge about the impacts of vaccination on pregnancy, fetal development, and child wellbeing was the main reason for hesitancy.

VACCINE (2022)

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Review Immunology

Pregnant women & vaccines against emerging epidemic threats: Ethics guidance for preparedness, research, and response

Carleigh B. Krubiner et al.

Summary: Zika virus, influenza, and Ebola outbreaks have shed light on the unique impacts on pregnant women and their offspring, highlighting the need for proactive consideration in vaccine research and response efforts. The exclusion of pregnant women in research agendas and vaccine campaigns is unjust and problematic from a public health perspective. To address these issues, new approaches to public health preparedness and vaccine research are necessary.

VACCINE (2021)

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Article Immunology

Ending the evidence gap for pregnancy, HIV and co-infections: ethics guidance from the PHASES project

Anne Drapkin Lyerly et al.

Summary: Despite the importance of pregnant individuals in HIV research, there are still critical evidence gaps that could lead to harm. An international and interdisciplinary working group has developed ethics-centered guidance to advance responsible research with pregnant individuals, aiming to bridge these gaps and improve outcomes for both mothers and babies.

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY (2021)

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Article Obstetrics & Gynecology