4.6 Article

Effect of the GLP-1 receptor agonist semaglutide on metabolic disturbances in clozapine-treated or olanzapine-treated patients with a schizophrenia spectrum disorder: study protocol of a placebo-controlled, randomised clinical trial (SemaPsychiatry)

Related references

Note: Only part of the references are listed.
Review Psychiatry

Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors

Christoph U. Correll et al.

Summary: People with schizophrenia have a significantly higher risk of premature death compared to the general population. This increased mortality risk is associated with factors such as suicide and natural causes. Antipsychotic medications, particularly second-generation long-acting injectable antipsychotics and clozapine, can reduce the risk of all-cause mortality in individuals with schizophrenia. Targeted treatment and early use of antipsychotics can help mitigate this mortality gap.

WORLD PSYCHIATRY (2022)

Editorial Material Psychiatry

Antipsychotic-induced weight gain: Is the weight over? New guidelines needed

Nini de Boer et al.

ACTA PSYCHIATRICA SCANDINAVICA (2022)

Article Clinical Neurology

A Guideline and Checklist for Initiating and Managing Clozapine Treatment in Patients with Treatment-Resistant Schizophrenia

C. U. Correll et al.

Summary: This study critically reviewed the use of clozapine in the treatment of treatment-resistant schizophrenia (TRS) and proposed strategies to improve its safety and tolerability, supporting early initiation of clozapine therapy for TRS patients. Additionally, a practical checklist was provided to identify and manage TRS patients, aiming to increase confidence in prescribing and monitoring clozapine therapy.

CNS DRUGS (2022)

Article Chemistry, Analytical

Criterion Validity of Linear Accelerations Measured with Low-Sampling-Frequency Accelerometers during Overground Walking in Elderly Patients with Knee Osteoarthritis

Arash Ghaffari et al.

Summary: This study aimed to determine the validity and reliability of low-sampling-frequency accelerometers in patients with knee osteoarthritis. The results showed that the low-sampling-frequency accelerometers provided valid and reliable data for measuring gait accelerations in these patients and could be used for remote patient monitoring in the future.

SENSORS (2022)

Review Psychiatry

A systematic review of licensed weight-loss medications in treating antipsychotic-induced weight gain and obesity in schizophrenia and psychosis

Kenn Lee et al.

Summary: This study evaluated the efficacy of licensed weight loss medications (WLMs) for treating antipsychotic-induced weight gain (AIWG) and obesity in schizophrenia and psychosis. The findings showed that liraglutide had the strongest evidence compared to other licensed WLMs in improving weight, BMI, waist circumference, HbA1c, cholesterol, and LDL readings. This evidence supports the use of liraglutide in treating AIWG and OSP.

GENERAL HOSPITAL PSYCHIATRY (2022)

Review Psychiatry

Continuing, reducing, switching, or stopping antipsychotics in individuals with schizophrenia-spectrum disorders who are clinically stable: a systematic review and network meta-analysis

Giovanni Ostuzzi et al.

Summary: Antipsychotic maintenance treatment is widely recommended to prevent relapse in chronic psychoses. This study compared different maintenance treatment strategies and found that continuing antipsychotic treatment at standard doses or switching to a different antipsychotic are similarly effective strategies, while reducing antipsychotic doses below standard doses is associated with a higher risk of relapse.

LANCET PSYCHIATRY (2022)

Article Endocrinology & Metabolism

The use of liraglutide 3.0 mg daily in the management of overweight and obesity in people with schizophrenia, schizoaffective disorder and first episode psychosis: Results of a pilot randomized, double-blind, placebo-controlled trial

Clare A. Whicher et al.

Summary: The study aimed to investigate the feasibility and acceptability of using liraglutide in managing obesity in individuals with severe mental illness. Results showed significant weight loss in the liraglutide group, supporting the need for a larger randomized controlled trial.

DIABETES OBESITY & METABOLISM (2021)

Article Psychiatry

Liraglutide does not change bone turnover in clozapine- and olanzapine-treated schizophrenia overweight patients with prediabetes - randomized controlled trial

Henrik Maagensen et al.

Summary: The study found that treatment with liraglutide did not have any significant impact on bone turnover markers in patients with schizophrenia and prediabetes. Additionally, there was no association between changes in bone turnover markers and changes in body weight in the liraglutide-treated group. This suggests that liraglutide may not have adverse effects on bone metabolism in these patients.

PSYCHIATRY RESEARCH (2021)

Review Psychiatry

Does Switching Antipsychotics Ameliorate Weight Gain in Patients With Severe Mental Illness? A Systematic Review and Meta-analysis

Dan Siskind et al.

Summary: Switching to antipsychotics with lower weight gain potential, such as aripiprazole and ziprasidone, can improve weight profile and other cardiometabolic outcomes in patients with severe mental illness. It is important to consider the weight gain potential of both the pre- and post-switch antipsychotic agents when making medication changes to ensure the patient's psychiatric stability and reduce the risk of cardiometabolic diseases.

SCHIZOPHRENIA BULLETIN (2021)

Article Psychiatry

Effect of liraglutide 3.0mg treatment on weight reduction in obese antipsychotic-treated patients

Seung Eun Lee et al.

Summary: Liraglutide 3.0 mg significantly reduces body weight in obese patients treated with antipsychotic drugs without affecting psychiatric conditions. However, some patients may experience mild nausea as a side effect, and half of the patients lost more than 5% of body weight after 16 weeks of treatment.

PSYCHIATRY RESEARCH (2021)

Review Clinical Neurology

Efficacy and tolerability of pharmacological interventions on metabolic disturbance induced by atypical antipsychotics in adults: A systematic review and network meta-analysis

Yewei Wang et al.

Summary: This study qualitatively compared the effects of different drugs on metabolic abnormalities induced by atypical antipsychotics using network meta-analysis. The evidence from this study suggests that zonisamide, metformin, GLP-1RAs, and nizatidine should be the first-line treatments for alleviating weight gain or elevated BMI induced by AAPs in adults, considering both efficacy and tolerability.

JOURNAL OF PSYCHOPHARMACOLOGY (2021)

Article Psychology, Clinical

Clinical Guidance on the Identification and Management of Treatment-Resistant Schizophrenia

John M. Kane et al.

JOURNAL OF CLINICAL PSYCHIATRY (2019)

Article Endocrinology & Metabolism

Glucagon-like peptide-1 receptor agonists and fracture risk: a network meta-analysis of randomized clinical trials

Y. S. Zhang et al.

OSTEOPOROSIS INTERNATIONAL (2018)

Article Psychiatry

Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000-2014

Joseph F. Hayes et al.

BRITISH JOURNAL OF PSYCHIATRY (2017)

Article Psychiatry

PANSS-6: a brief rating scale for the measurement of severity in schizophrenia

S. D. Ostergaard et al.

ACTA PSYCHIATRICA SCANDINAVICA (2016)

Article Medicine, General & Internal

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

Steven P. Marso et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, General & Internal

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

Steven P. Marso et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Endocrinology & Metabolism

GLP-1 Receptor Agonist Treatment Increases Bone Formation and Prevents Bone Loss in Weight-Reduced Obese Women

Eva W. Iepsen et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Article Chemistry, Medicinal

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

Jesper Lau et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Medicine, General & Internal

Schizophrenia

Rene S. Kahn et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Article Pharmacology & Pharmacy

Effect of Topiramate on Weight Gain in Patients Receiving Atypical Antipsychotic Agents

Shamail Mahmood et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2013)

Article Medicine, General & Internal

SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials

An-Wen Chan et al.

BMJ-BRITISH MEDICAL JOURNAL (2013)

Article Nutrition & Dietetics

Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task

Alexander D. Miras et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2012)

Review Psychiatry

Life expectancy and cardiovascular mortality in persons with schizophrenia

Thomas M. Laursen et al.

CURRENT OPINION IN PSYCHIATRY (2012)

Review Endocrinology & Metabolism

Metabolic and cardiovascular adverse effects associated with antipsychotic drugs

Marc De Hert et al.

NATURE REVIEWS ENDOCRINOLOGY (2012)

Review Pharmacology & Pharmacy

Metformin for olanzapine-induced weight gain: a systematic review and meta-analysis

Samir Kumar Praharaj et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2011)

Editorial Material Psychiatry

Physical health disparities and mental illness: the scandal of premature mortality

Graham Thornicroft

BRITISH JOURNAL OF PSYCHIATRY (2011)

Review Biochemistry & Molecular Biology

Antipsychotic drugs and obesity

Christoph U. Correll et al.

TRENDS IN MOLECULAR MEDICINE (2011)

Article Radiology, Nuclear Medicine & Medical Imaging

Radiation exposure in X-ray-based imaging techniques used in osteoporosis

John Damilakis et al.

EUROPEAN RADIOLOGY (2010)

Review Physiology

The physiology of glucagon-like peptide 1

Jens Juul Holst

PHYSIOLOGICAL REVIEWS (2007)

Article Cardiac & Cardiovascular Systems

Schizophrenia and increased risks of cardiovascular disease

CH Hennekens et al.

AMERICAN HEART JOURNAL (2005)

Article Psychiatry

Diet, smoking and cardiovascular risk in people with schizophrenia - Descriptive study

RG McCreadie

BRITISH JOURNAL OF PSYCHIATRY (2003)

Article Psychiatry

Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: A five-year naturalistic study

DC Henderson et al.

AMERICAN JOURNAL OF PSYCHIATRY (2000)