Consistency of efficacy results across various clinical measures and statistical methods in the lecanemab phase 2 trial of early Alzheimer's disease

Article Clinical Neurology

Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease

S. Budd Haeberlein et al.

Summary: Aducanumab showed significant changes in early Alzheimer's disease patients in one trial, but did not meet primary or secondary endpoints in another study. Both trials demonstrated a dose- and time-dependent reduction in pathophysiological markers of Alzheimer's disease.

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE (2022)

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Article Medicine, General & Internal

Donanemab in Early Alzheimer's Disease

Mark A. Mintun et al.

Summary: In this study, donanemab showed improved composite scores for cognition and daily living activities compared to placebo in patients with early Alzheimer's disease at 76 weeks, although secondary outcomes varied. Longer and larger trials are needed to further explore the efficacy and safety of donanemab in Alzheimer's disease.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Clinical Neurology

A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody

Chad J. Swanson et al.

Summary: BAN2401-G000-201 trial aimed to establish the effective dose and observe the treatment effect. While not meeting the primary endpoint at 12 months, results at 18 months demonstrated reduction in brain amyloid and improvement across multiple clinical and biomarker endpoints.

ALZHEIMERS RESEARCH & THERAPY (2021)

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Article Mathematical & Computational Biology